Plastic Surgery Reconstruction of Sarcoma Resection Defects

Stiles, Zachary E.; Lohman, Robert; Mann, Gary N.

doi:10.1016/j.suc.2022.04.008

Cited by 7 publications

(5 citation statements)

References 95 publications

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“…Following adequate oncologic resection, plastic reconstruction should focus on maintaining function and aesthetic with minimal postoperative complications. This makes the plastic surgeon be actively involved in treatment planning, thus being an integral member of the multidisciplinary team [37].…”

Section: Discussionmentioning

confidence: 99%

A Planned Multidisciplinary Surgical Approach to Treat Primary Pelvic Malignancies

et al. 2023

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The pelvic anatomy poses great challenges to orthopedic surgeons. Sarcomas are often large in size and typically enclosed in the narrow confines of the pelvis with the close proximity of vital structures. The aim of this study is to report a systematic planned multidisciplinary surgical approach to treat pelvic sarcomas. Seventeen patients affected by bone and soft tissue sarcomas of the pelvis, treated using a planned multidisciplinary surgical approach, combining the expertise of orthopedic oncology and other surgeons (colleagues from urology, vascular surgery, abdominal surgery, gynecology and plastic surgery), were included. Seven patients were treated with hindquarter amputation; 10 patients underwent excision of the tumor. Reconstruction of bone defects was conducted in six patients with a custom-made 3D-printed pelvic prosthesis. Thirteen patients experienced at least one complication. Well-organized multidisciplinary collaborations between each subspecialty are the cornerstone for the management of patients affected by pelvic sarcomas, which should be conducted in specialized centers. A multidisciplinary surgical approach is of paramount importance in order to obtain the best successful surgical results and adequate margins for achieving acceptable outcomes.

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Section: Discussionmentioning

confidence: 99%

A Planned Multidisciplinary Surgical Approach to Treat Primary Pelvic Malignancies

et al. 2023

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“…Many tumors are also frequently encountered in clinical work. Breast cancer, head and neck squamous cell carcinoma, sarcoma, and skin cutaneous melanoma are all common tumors in plastic and aesthetic (burn) surgery [4][5][6][7]. As of now, the etiology and mechanisms of tumors have not been fully understood [8].…”

Section: Introductionmentioning

confidence: 99%

Multi-omics analysis of the oncogenic role of optic atrophy 1 in human cancer

Wu,

Xu,

et al. 2023

Aging

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Objective: To investigate the prognostic significance of optic atrophy 1 ( OPA1 ) in pan-cancer and analyze the relationship between OPA1 and immune infiltration in cancer. Results: OPA1 exhibited high expression levels or mutations in various types of tumor cells, and its expression levels were significantly correlated with the survival rate of tumor patients. In different tumor tissues, there was a notable positive correlation between OPA1 expression levels and the infiltration of cancer-associated fibroblasts in the immune microenvironment. Additionally, OPA1 and its related genes were found to be involved in several crucial biological processes, including protein phosphorylation, protein import into the nucleus, and protein binding. Conclusion: OPA1 is highly expressed or mutated in numerous tumors and is strongly associated with protein phosphorylation, patient prognosis, and immune cell infiltration. OPA1 holds promise as a novel prognostic marker with potential clinical utility across various tumor types. Methods: We examined OPA1 expression in pan-cancer at both the gene and protein levels using various databases, including Tumor Immune Estimation Resource 2.0 (TIMER 2.0), Gene Expression Profiling Interactive Analysis (GEPIA2), UALCAN, and The Human Protein Atlas (HPA). We utilized the Kaplan-Meier plotter and GEPIA datasets to analyze the relationship between OPA1 expression levels and patient prognosis. Through the cBioPortal database, we detected OPA1 mutations in tumors and examined their relationship with patient prognosis. We employed the TIMER 2.0 database to explore the correlation between OPA1 expression levels in tumor tissue and the infiltration of cancer-associated fibroblasts in the immune microenvironment. Furthermore, we conducted a gene search associated with OPA1 and performed enrichment analysis to identify the main signaling pathways and biological processes linked to them.

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“…1 Surgical excision is the mainstay of treatment, with management historically involving radical amputation with wide margins. [2][3][4][5] As treatment paradigms have shifted to limb-sparing…”

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confidence: 99%

“…1 Surgical excision is the mainstay of treatment, with management historically involving radical amputation with wide margins. 2–5 As treatment paradigms have shifted to limb-sparing approaches, the literature has emerged that describes comparable survival rates and superior functional outcomes in limb-sparing surgery compared with amputation. 2 Standard of care now involves a multidisciplinary approach with excision by orthopaedic or surgical oncology teams and soft tissue reconstruction frequently performed by plastic surgeons.…”

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confidence: 99%

A Systematic Review of the Orthoplastic Approach in Adult Lower Extremity Soft Tissue Sarcoma Flap Reconstruction

LaValley,

Dugue,

Diaddigo

et al. 2024

JAAOS Glob Res Rev

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Background: The orthoplastic approach to patient care has changed the way patients with a wide variety of lower extremity pathology are treated. Through a systematic review, we aim to analyze outcomes in adult patients with lower extremity soft tissue sarcomas who undergo an orthoplastic flap management approach to their care. Methods: A systematic review of adult lower extremity soft tissue sarcoma excision with plastic surgery flap reconstruction was conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines searching the Pubmed, Embase, and Web of Science databases from inception to April 2023. Results: After removal of duplicates, title and abstract screening, and full-text review, 26 articles were accepted for inclusion. The total mean follow-up duration was 32.0 ± 24.3 months. Reconstruction used microvascular free flaps in 65.5% (487/743), while 34.5% (256/743) were local flaps. 85.8% (307/358) of patients ambulated postoperatively. Revision surgery was required in 21% of patients during their respective follow-up periods. The limb salvage rate was 93.4% (958/1,026). Among pooled surgical outcomes, 22.2% (225/1,012) of patients experienced a perioperative complication. Discussion: Our study demonstrates that although complication rates in lower extremity soft tissue sarcoma reconstruction may be further optimized, a multidisciplinary flap reconstructive approach provides high rates of limb salvage and functional postoperative ambulation.

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Plastic Surgery Reconstruction of Sarcoma Resection Defects

Cited by 7 publications

References 95 publications

A Planned Multidisciplinary Surgical Approach to Treat Primary Pelvic Malignancies

A Planned Multidisciplinary Surgical Approach to Treat Primary Pelvic Malignancies

Multi-omics analysis of the oncogenic role of optic atrophy 1 in human cancer

A Systematic Review of the Orthoplastic Approach in Adult Lower Extremity Soft Tissue Sarcoma Flap Reconstruction

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