Plasticity in dendrites shown by continuous GABA administration in superior cervical ganglion of adult rat

Wolff, Joachim R.; Joó, Ferenc; Dames, W.

doi:10.1038/274072a0

Cited by 152 publications

(47 citation statements)

References 17 publications

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“…In agreement with previous sugges tions [ Wolff et al, 1978Wolff et al, , 1979Spoerri and Wolff, 1981;Eins et al, 1983] it was found that treatment of the cultures with 50 p.M GABA led to an enhanced differentiation of the neurons both at light-and electron-mi croscopic levels [Meier et al, 1983a;Hansen et al, 1984]. It was found that the treatment of the cultures with GABA led to an enhanced development of the cytoplasmic density of certain ultrastructures such as neurotubules, Golgi apparatus, vesicles and rough endo plasmic reticulum, whereas others, such as mitochondria and smooth endoplasmic re ticulum, were unaffected (table I).…”

Section: Morphological Studiessupporting

confidence: 82%

Cultured Neurons as Model Systems for Biochemical and Pharmacological Studies on Receptors for Neurotransmitter Amino Acids

et al. 1985

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By the use of primary cultures of neurons consisting of cerebral cortex interneurons or cerebellar granule cells it is possible to study biochemical and pharmacological aspects of receptors for GABA and glutamate. Cerebellar granule cells have been shown to express both high- and low-affinity GABA receptors. The latter ones develop, however, only when the neurons are treated with GABA or GABA receptor agonists. It is suggested that the high-affinity receptors play a role in the neurotrophic activity of GABA, whereas the low-affinity GABA receptors are involved in the mediation of the inhibitory action of GABA on evoked release of glutamate, which is the neurotransmitter in cerebellar granule cells. Also glutamate receptors have been studied with regard to the 2 types of neurons. Both cerebral cortex neurons (GABAergic) and cerebellar granule cells (glutamatergic) possess glutamate receptors, which mediate an L-glutamate-induced transmitter release. The pharmacological properties of these glutamate receptors are, however, distinctly different for the 2 types of neurons. While cerebral cortex neurons express both quisqualate-, N-methyl-D-aspartate- and kainate-receptors, the cerebellar granule cells have a receptor which is activated only by L-glutamate and L-aspartate.

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Section: Morphological Studiessupporting

confidence: 82%

Cultured Neurons as Model Systems for Biochemical and Pharmacological Studies on Receptors for Neurotransmitter Amino Acids

et al. 1985

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“…Another mechanism could involve alterations in neuronal differentiation. In several systems, GABA and GABA agonists can accelerate neuronal maturation and the formation of functional synapses (Ben Ari et al, 1994;LoTurco et al, 1995;Spoerri and Wolff, 1981;Wolff et al, 1978). Acceleration of ORN maturation could lead to reductions in the ability of a cell to sustain neurite outgrowth.…”

Section: Olfactory Nerve Regenerationmentioning

confidence: 97%

“…In recent years, neurotransmitters have been implicated in short-range modulation of neural migration and axon growth. For example, glutamate, via NMDA receptors, can act as either a growth promoting factor in hippocampal neurons (Mattson et al, 1988), cerebellar granule cells (Pearce et al, 1987), and spinal neurons (Zheng et al, 1996), or as a "stop growth" signal for basilar pontine neuron extension (Baird et al, 1996), and GABA can promote cell migration (Behar et al, 1995(Behar et al, , 1996(Behar et al, , 2000(Behar et al, , 2001Fueshko et al, 1998), neural differentiation (Ben Ari et al, 1994;LoTurco et al, 1995), neurite outgrowth (Michler, 1990;Barbin et al, 1993;Obrietan and van den Pol, 1996;Matsutani and Yamamoto, 1998), and synapse formation (Spoerri and Wolff, 1981;Wolff et al, 1978). This growing body of evidence suggests that GABA, as well as other neurotransmitters, plays a role in axon guidance and target choice.…”

Section: Introductionmentioning

confidence: 99%

GABA_B receptor expression and function in olfactory receptor neuron axon growth

Priest

Puché

2004

J. Neurobiol.

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Neurotransmitters have been implicated in regulating growth cone motility and guidance in the developing nervous system. Anatomical and electrophysiological studies show the presence of functional GABAB receptors on adult olfactory receptor neuron (ORN) nerve terminals. Using antisera against the GABAB R1a/b receptor isoforms we show that developing mouse olfactory receptor neurons express GABAB receptors from embryonic day 14 through to adulthood. GABAB receptors are present on axon growth cones from both dissociated ORNs and olfactory epithelial explants. Neurons in the olfactory bulb begin to express glutamic acid decarboxylase (GAD), the synthetic enzyme for GABA, from E16 through to adulthood. When dissociated ORNs were cultured in the presence of the GABAB receptor agonists, baclofen or SKF97541, neurite outgrowth was significantly reduced. Concurrent treatment of the neurons with baclofen and the GABAB receptor antagonist CGP54626 prevented the inhibitory effects of baclofen on ORN neurite outgrowth. These results show that growing ORN axons express GABAB receptors and are sensitive to the effects of GABAB receptor activation. Thus, ORNs in vivo may detect GABA release from juxtaglomerular cells as they enter the glomerular layer and use this as a signal to limit their outgrowth and find synaptic targets in regeneration and development.

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“…In addition to acting as neuromodulators, in fact, they serve as trophic factors regulating the development, maintenance, and plasticity of neuronal morphology (Lipton and Kater, 1989). GABA has attracted considerable attention in this respect: In vitro experiments have shown that it facilitates synaptogenesis (Wolff, 1978;Wolff et al, 1993), stimulates (like the nerve growth factor) the migration of neurons to their final position (Behar et al, 19941, and promotes neurite outgrowth and differentiation (Spoerri and Wolff, 1981). In particular, its trophic effect on neuronal development was suggested by Lauder et al (19861, who showed that the trajectories taken by growing rat brain GABAergic fibers by embryonic day 13 are located within regions of both monoaminergic and peptidergic neuronal differentiation and correspond to the slightly later patterns of benzodiazepine receptors (Schlumpf et al, 1983).…”

Section: Functional Meaning Of Gaba Transiencementioning

confidence: 97%

Immunohistochemical investigation of γ‐aminobutyric acid ontogeny and transient expression in the central nervous system of Xenopus laevis tadpoles

et al. 1996

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The ontogeny of the gamma-aminobutyric acid (GABA)-positive neurons in the brain of Xenopus laevis tadpoles was investigated by means of immunohistochemistry, using specific antibodies both against GABA and its biosynthetic enzyme, glutamate decarboxylase (GAD). The results obtained with the two antisera were comparable. The GABA system differentiates very early during development. At stages 35/36, numerous GABA-positive neurons were seen throughout the prosencephalon and formed two main bilateral clusters within the lateral walls of the forebrain that ran caudally toward the hindbrain. Other GABA-immunolabeled cell bodies, together with a conspicuous network of GABAergic fibers, were seen in the posterior hypothalamus. In the spinal cord, the lateral marginal zone was GABA-positive, as were Rohon-Beard neurons, interneurons, and Kolmer-Agdhur cells. A very rich GABA innervation was observed in the pars intermedia of the pituitary. At stage 50, plentiful immunopositive neurons and fibers were found in the telencephalic hemispheres, the diencephalon, and the mesencephalon (optic tectum and tegmentum). By stage 54, the number of GABA-immunoreactive neurons in the posterior hypothalamus had decreased, so that, at stage 58, there were very few GABA-labeled cell bodies in the dorsolateral walls of the infundibulum, despite a strong GABAergic innervation within the median eminence and the pars intermedia. From stage 58 to stage 66, the distribution pattern was very similar to that described in the adult X. laevis and in other amphibian species. These results point to transient GABA expression within the hypothalamus, possibly related to either 1) a naturally occurring cell death or 2) a phenotypic switch.

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Plasticity in dendrites shown by continuous GABA administration in superior cervical ganglion of adult rat

Cited by 152 publications

References 17 publications

Cultured Neurons as Model Systems for Biochemical and Pharmacological Studies on Receptors for Neurotransmitter Amino Acids

Cultured Neurons as Model Systems for Biochemical and Pharmacological Studies on Receptors for Neurotransmitter Amino Acids

GABA_B receptor expression and function in olfactory receptor neuron axon growth

Immunohistochemical investigation of γ‐aminobutyric acid ontogeny and transient expression in the central nervous system of Xenopus laevis tadpoles

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Plasticity in dendrites shown by continuous GABA administration in superior cervical ganglion of adult rat

Cited by 152 publications

References 17 publications

Cultured Neurons as Model Systems for Biochemical and Pharmacological Studies on Receptors for Neurotransmitter Amino Acids

Cultured Neurons as Model Systems for Biochemical and Pharmacological Studies on Receptors for Neurotransmitter Amino Acids

GABAB receptor expression and function in olfactory receptor neuron axon growth

Immunohistochemical investigation of γ‐aminobutyric acid ontogeny and transient expression in the central nervous system of Xenopus laevis tadpoles

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GABA_B receptor expression and function in olfactory receptor neuron axon growth