Plasticity of neuroendocrine–thymus interactions during ontogeny and ageing: Role of zinc and arginine

Mocchegiani, Eugenio; Santarelli, Lory; Costarelli, Laura; Cipriano, Catia; Muti, Elisa; Giacconi, Robertina; Malavolta, Marco

doi:10.1016/j.arr.2006.06.001

Cited by 44 publications

(53 citation statements)

References 119 publications

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“…The markedly reduced size of the naïve T-cell subpopulation together with an increased number of memory cells in the periphery, is a clear-cut characteristic of ageing in the immune cells (Romanyukha and Yashin, 2003). However, recently, Mocchegiani et al (2006) reported that certain nutrition might effects thymic physiology. Studies on animals have shown that oral zinc supplement in aged mice induced thymus re-growth couple with an increase in the production of thymic hormone.…”

Section: Peripheral Blood Mononuclear Cellsmentioning

confidence: 99%

Evaluation of Immunomodulatory Effect: Selection of the Correct Targets for Immunostimulation Study

Chun-Chu¹

2011

American Journal of Immunology

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Problem statement: Numerous plants or remedies that are traditionally used for various diseases had been claimed to maintain general good health, particularly the immune system. With the advanced understanding on immunology and ethnopharmacology, study on the interaction of this herb with the immune system is critical to understand the safety and its efficacy as a potent immunomodulatory agent. Approach: Selecting proper immune cells from a suitable immune organ allowed for the understanding on the mode of immunomodulation. Lymphocytes isolated from mammalian thymus, spleen and bone marrow represented great candidates for this immunomodulatory study. Results: A number of herbal extracts including that of Rhaphidophora korthalsii and compounds isolated from this plant, namely lectin and zerumbone, had been identified as potent immunostimulators. Conclusion/Recommendations: Future studies are needed to elucidate the mechanism underlaying activites of these immunomodulatory agents.

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Section: Peripheral Blood Mononuclear Cellsmentioning

confidence: 99%

Evaluation of Immunomodulatory Effect: Selection of the Correct Targets for Immunostimulation Study

Chun-Chu¹

2011

American Journal of Immunology

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“…Thymic re-growth and reactivation of thymic functions may be achieved in old animals by different endocrinological or nutritional manipulations such as treatment with melatonin. Melatonin may also act through specific receptors on T-cells 112 .…”

Section: Melatonin and Ageingmentioning

confidence: 99%

Untitled

2013

IJPSR

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ABSTRACT:Introduction: Melatonin is a neuro-hormone secreted from the pineal gland and involved in various regulatory activities in body. Ever-increasing use of melatonin supplements and enlarging research evidences make the authors undertook the review to arrive at a qualitative conclusion whether melatonin supplements can act as potential treatment options or not. Methodology: A comprehensive search was undertaken in different electronic databases using various search terms. A total of 225 studies were identified including clinical research studies and basic experiments. Data were extracted individually from the studies and compiled in the end. Results: Melatonin has been used successfully in chronic insomnia and as an anti-oxidant in cancer and other age-related neuro-degenerative disorders, especially Alzheimer's disease and Autistic disorders. Its evidences of use in other conditions remained insufficient and inconclusive. Conclusion: Melatonin therapy may be considered as efficacious and safe in insomnia and as an anti-oxidant; however, other roles needs to be evaluated in further studies.

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“…In a previous study, we described a relationship between thymulin and the vasodilating gas nitric oxide (NO) 9) . NO is generated from the terminal guanidino nitrogen of L-arginine via an oxidative process catalyzed by nitric oxide synthase (NOS).…”

Section: Introductionmentioning

confidence: 99%

“…Thymic epithelial cells secrete thymulin, a zinc-dependent nonapeptide hormone with a large role in immune regulation 7) , whose production declines during chronic inflammation and ageing 8,9) . Hg 2+ impairs active thymulin production both in vitro and in vivo 10,11) , possibly due to inhibition of protein synthesis 12) and to a mechanism involving direct substitution of zinc with Hg 2+ in thymulin molecules, resulting in reduced hormone activity 5,13,14) .…”

Section: Introductionmentioning

confidence: 99%

L-arginine Reduces Mercury Accumulation in Thymus of Mercury-exposed Mice: Role of Nitric Oxide Synthase Activity and Metallothioneins

Bracci

Tomasetti

Malavolta³

et al. 2008

Ind Health

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Plasticity of neuroendocrine–thymus interactions during ontogeny and ageing: Role of zinc and arginine

Cited by 44 publications

References 119 publications

Evaluation of Immunomodulatory Effect: Selection of the Correct Targets for Immunostimulation Study

Evaluation of Immunomodulatory Effect: Selection of the Correct Targets for Immunostimulation Study

Untitled

L-arginine Reduces Mercury Accumulation in Thymus of Mercury-exposed Mice: Role of Nitric Oxide Synthase Activity and Metallothioneins

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