Plasticity of resting state brain networks in recovery from stress

Soares, José Miguel; Sampaio, Adriana; Marques, Paulo; Ferreira, Luís Miguel Santos; Santos, Nadine Correia; Marques, Fernanda; Palha, Joana Almeida; Cerqueira, João José; Sousa, Nuno

doi:10.3389/fnhum.2013.00919

Cited by 34 publications

(27 citation statements)

References 42 publications

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“…The few previous studies investigating the effect of stress on DMN point to a generalized increase of FC under prolonged stress conditions (Soares et al 2013a, b; Vaisvaser et al 2013). In this study, and in line with our previous findings in young participants, an increased FC in the more stressed participants (that is, higher PSS scores) was found in the DMN, suggesting augmented self-reflective thoughts and emotional processing (Soares et al 2013a).…”

Section: Discussionmentioning

confidence: 94%

“…Importantly, most of these maladaptive structural and functional responses to increased chronic stress were reported in young and middle-aged subjects and were in part shown to be reversible (Bian et al 2012; Soares et al 2012; Sousa et al 2000). Moreover, we have recently shown that stressed subjects present increased activation of the DMN, associated with impairments in the deactivation pattern and paralleled by a network volumetric atrophy (Soares et al 2013a) that is recovered after a stress-free period in young individuals (Soares et al 2013b). Emerging findings from major depression studies have pointed to altered connectivity and abnormal deactivation patterns in the DMN.…”

Section: Introductionmentioning

confidence: 99%

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The association between stress and mood across the adult lifespan on default mode network

et al. 2016

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Aging of brain structure and function is a complex process characterized by high inter- and intra-individual variability. Such variability may arise from the interaction of multiple factors, including exposure to stressful experience and mood variation, across the lifespan. Using a multimodal neuroimaging and neurocognitive approach, we investigated the association of stress, mood and their interaction, in the structure and function of the default mode network (DMN), both during rest and task-induced deactivation, throughout the adult lifespan. Data confirmed a decreased functional connectivity (FC) and task-induced deactivation of the DMN during the aging process and in subjects with lower mood; on the contrary, an increased FC was observed in subjects with higher perceived stress. Surprisingly, the association of aging with DMN was altered by stress and mood in specific regions. An increased difficulty to deactivate the DMN was noted in older participants with lower mood, contrasting with an increased deactivation in individuals presenting high stress, independently of their mood levels, with aging. Interestingly, this constant interaction across aging was globally most significant in the combination of high stress levels with a more depressed mood state, both during resting state and task-induced deactivations. The present results contribute to characterize the spectrum of FC and deactivation patterns of the DMN, highlighting the crucial association of stress and mood levels, during the adult aging process. These combinatorial approaches may help to understand the heterogeneity of the aging process in brain structure and function and several states that may lead to neuropsychiatric disorders.

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Section: Discussionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

The association between stress and mood across the adult lifespan on default mode network

et al. 2016

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“…These CPS findings are of translational interest, given that FCs within and between regions comprising the DMN, namely cingulate, prefrontal, parietal and temporal cortices, are also increased in humans in states of chronic stress or depression (Broyd et al, 2009;Grimm et al, 2009;Soares et al, 2013;Whitfield-Gabrieli and Ford, 2012). Connectivity within the human DMN is proposed to relate to self-absorption and rumination.…”

Section: Increases In Within-and Between-network Functional Connectivmentioning

confidence: 90%

“…For example, the default mode network (DMN), involving cingulate, prefrontal, parietal and temporal cortices (Broyd et al, 2009), is proposed to relate to self-absorption and rumination. In fact, FC within the DMN is increased by stress (Soares et al, 2013) and in depression (Grimm et al, 2009;Whitfield-Gabrieli and Ford, 2012). In addition to these analyses of the changes in brain function underlying depression, region-specific metabolic changes as derived from MRS have been reported for depressed patients (Hasler et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Chronic psychosocial stress in mice leads to changes in brain functional connectivity and metabolite levels comparable to human depression

et al. 2016

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Human depression, for which chronic psychosocial stress is a major risk factor, is characterized by consistent alterations in neurocircuitry. For example, there is increased functional connectivity (FC) within and between regions comprising the default mode network (DMN) including prefrontal cortex and cingulate cortex. Alterations in network FC are associated with specific aspects of psychopathology. In mice, chronic psychosocial stress (CPS) leads to depression-relevant behavior, including increased fear learning, learned helplessness, fatigue and decreased motivation for reward. Using multimodal in vivo magnetic resonance imaging (MRI) and spectroscopy (MRS), we investigated CPS effects on function and structure in the mouse brain under light anesthesia. Mice underwent a baseline MRI/MRS session, followed by 15-day CPS (n=26) or control handling (n=27), and a post-treatment MRI/MRS session. In BOLD fMRI, relative to controls, CPS mice exhibited robust, reproducible increases in FC within 8 of 9 identified cortical networks, including the prefrontal and cingulate cortices that contribute to the "mouse DMN". CPS mice exhibited increases in between-network FC, including amygdala -prefrontal cortex and amygdala -cingulate cortex. MRS identified metabolic alterations in CPS mice as increased inositol levels in amygdala and increased glycerophosphorylcholine levels in prefrontal cortex. Diffusion-weighted MRI detected increased fractional anisotropic values in the cingulum. This study demonstrates that chronic psychosocial stress induces FC states in the mouse brain analogous to those observed in depression, as well as cerebral metabolism and white matter pathway alterations that contribute to understanding of pathological processes. It also demonstrates the importance of brain imaging to the establishment of valid animal models in translational psychiatry. AbstractHuman depression, for which chronic psychosocial stress is a major risk factor, is characterized by consistent alterations in neurocircuitry. For example, there is increased functional connectivity (FC) within and between regions comprising the default mode network (DMN) including prefrontal cortex and cingulate cortex. Alterations in network FC are associated with specific aspects of psychopathology. In mice, chronic psychosocial stress (CPS) leads to depression-relevant behavior, including increased fear learning, learned helplessness, fatigue and decreased motivation for reward.Using multimodal in vivo magnetic resonance imaging (MRI) and spectroscopy (MRS), we investigated CPS effects on function and structure in the mouse brain under light anesthesia. Mice underwent a baseline MRI/MRS session, followed by 15-day CPS (n=26) or control handling (n=27), and a posttreatment MRI/MRS session. In BOLD fMRI, relative to controls, CPS mice exhibited robust, reproducible increases in FC within 8 of 9 identified cortical networks, including the prefrontal and cingulate cortices that contribute to the "mouse DMN". CPS mice exhibited increases in b...

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“…Prolonged stress exposure in medical students i.e. leads to functional changes in several large-scale brain networks67. High stress as induced via presentation of highly aversive visual stimuli combined with a pharmacological intervention (β-adrenergic receptor blockade via propranolol) results in profound changes of interconnectivity within the salience network (SN).…”

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confidence: 99%

Alerted default mode: functional connectivity changes in the aftermath of social stress

Clemens

Wagels

Bauchmüller

et al. 2017

Sci Rep

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Stress affects the brain at a network level: the salience network is supposedly upregulated, while at the same time the executive control network is downregulated. While theoretically described, the effects in the aftermath of stress have thus far not been tested empirically. Here, we compared for the first time resting-state functional connectivity in a large sample of healthy volunteers before and after a mild social stressor. Following the theoretical prediction, we focused on connectivity of the salience network (SN), the executive control network (ECN) and the default mode network (DMN). The DMN exhibited increased resting-state functional connectivity following the cyberball task to the key nodes of the SN, namely the dorsal anterior cingulate cortex (dACC) and the anterior insula, as well as sensorimotor regions and higher-order visual areas. We conclude that this increased connectivity of the DMN with key nodes of the SN and regions responsible for preparatory motor activity and visual motion processing indicates a shift towards an ‘alerted default mode’ in the aftermath of stress. This brain response may be triggered or aggravated by (social) stress induced by the cyberball task, enabling individuals to better reorient attention, detect salient external stimuli, and deal with the emotional and affective consequences of stress.

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Plasticity of resting state brain networks in recovery from stress

Cited by 34 publications

References 42 publications

The association between stress and mood across the adult lifespan on default mode network

The association between stress and mood across the adult lifespan on default mode network

Chronic psychosocial stress in mice leads to changes in brain functional connectivity and metabolite levels comparable to human depression

Alerted default mode: functional connectivity changes in the aftermath of social stress

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