Plasticization and spraying of poly (DL‐lactic acid) using supercritical carbon dioxide: control of particle size

Hao, Jianyuan; Whitaker, Martin J.; Wong, Ben; Serhatkulu, Gulay K.; Shakesheff, Kevin M.; Howdle, Steven M.

doi:10.1002/jps.20002

Cited by 41 publications

(18 citation statements)

References 23 publications

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“…These versatile subunits can be produced using droplet formation of solvents (Suciati et al 2006) or by spraying (Hao et al 2004;Whitaker et al 2005). Setting of a microparticle slurry was initially performed using the attraction between biotin in one set of beads and avidin in another.…”

Section: Injectable Materials For Tissue Engineering/ Regenerative Mementioning

confidence: 99%

Tissue engineering: strategies, stem cells and scaffolds

et al. 2008

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Tissue engineering scaffolds are designed to influence the physical, chemical and biological environment surrounding a cell population. In this review we focus on our own work and introduce a range of strategies and materials used for tissue engineering, including the sources of cells suitable for tissue engineering: embryonic stem cells, bone marrow-derived mesenchymal stem cells and cord-derived mesenchymal stem cells. Furthermore, we emphasize the developments in custom scaffold design and manufacture, highlighting laser sintering, supercritical carbon dioxide processing, growth factor incorporation and zoning, plasma modification of scaffold surfaces, and novel multi-use temperature-sensitive injectable materials.

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Section: Injectable Materials For Tissue Engineering/ Regenerative Mementioning

confidence: 99%

Tissue engineering: strategies, stem cells and scaffolds

et al. 2008

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“…Different strategies can be used to improve the process performance depending on the difficulties experimented and that are in most of the cases inherent to the systems under investigation. Hao et al [37] reported the use of a nitrogen back pressure to suppress the loss of CO 2 from the P DL LA/CO 2 liquefied mixture and in that way slow down the rate of polymer solidification to achieve the production of fine particles. The authors have also cooled the collection chamber with liquid nitrogen to prevent aggregation of the newly formed microparticles.…”

Section: The Particles From Gas Saturated Solution (Pgss) Techniquementioning

confidence: 99%

Dense CO2 as a Solute, Co-Solute or Co-Solvent in Particle Formation Processes: A Review

Nunes

Duarte

2011

Materials

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The application of dense gases in particle formation processes has attracted great attention due to documented advantages over conventional technologies. In particular, the use of dense CO2 in the process has been subject of many works and explored in a variety of different techniques. This article presents a review of the current available techniques in use in particle formation processes, focusing exclusively on those employing dense CO2 as a solute, co-solute or co-solvent during the process, such as PGSS (Particles from gas-saturated solutions®), CPF (Concentrated Powder Form®), CPCSP (Continuous Powder Coating Spraying Process), CAN-BD (Carbon dioxide Assisted Nebulization with a Bubble Dryer®), SEA (Supercritical Enhanced Atomization), SAA (Supercritical Fluid-Assisted Atomization), PGSS-Drying and DELOS (Depressurization of an Expanded Liquid Organic Solution). Special emphasis is given to modifications introduced in the different techniques, as well as the limitations that have been overcome.

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“…The PGSS process utilizes the ability of scCO 2 to plasticize amorphous polymers such as PLGA and P DL LA and liquefy them at near ambient temperature. This enables drug powders to be homogenously mixed with liquefied polymer, and then the liquefied polymer/drug mixture is sprayed into a collection chamber to produce fibres or particles [13,14,36]. The PGSS process is particularly suitable for entrapment of delicate pharmaceuticals such as proteins [7,8,36].…”

Section: Microparticles Via Pgssmentioning

confidence: 99%

“…Solubilized scCO 2 can plasticize glassy polymers, leading to a dramatic decrease in the glass transition temperature (T g ) and can also reduce polymer melt viscosity. These effects have been used in many biomedical and tissue engineering applications, such as incorporation of bioactive additives [7,8] and formation of foams [9][10][11][12] and particles [13,14] for tissue engineering and drug delivery. Moreover, scCO 2 can even allow processing of delicate mammalian cells without compromising their activity [15].…”

Section: Introductionmentioning

confidence: 98%

Putting the fizz into chemistry: applications of supercritical carbon dioxide in tissue engineering, drug delivery and synthesis of novel block copolymers

Tai

Попов

Shakesheff

et al. 2007

Biochemical Society Transactions

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This paper describes the recent progress at Nottingham towards the exploitation of the unique properties of scCO(2) (supercritical carbon dioxide) for the preparation of polymeric scaffolds for tissue engineering applications and new devices for controlled drug delivery, as well as the synthesis of novel block copolymers by the combination of eROP (enzymatic ring opening polymerization) and controlled polymerization methods for the potential use as drug carriers.

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Plasticization and spraying of poly (DL‐lactic acid) using supercritical carbon dioxide: control of particle size

Cited by 41 publications

References 23 publications

Tissue engineering: strategies, stem cells and scaffolds

Tissue engineering: strategies, stem cells and scaffolds

Dense CO2 as a Solute, Co-Solute or Co-Solvent in Particle Formation Processes: A Review

Putting the fizz into chemistry: applications of supercritical carbon dioxide in tissue engineering, drug delivery and synthesis of novel block copolymers

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