Platelet-activating factor and lipid metabolism in acute malaria

Davis, Timothy M. E.; Sturm, M.; Zhang, Yuerong; Spencer, J L; Graham, Ross M.; Li, Guoqiao; Taylor, Roger R.

doi:10.1016/0163-4453(93)95405-8

Cited by 20 publications

(16 citation statements)

References 13 publications

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“…7 The extent of these serum lipid profile changes was not related to parasitemia, in contrast to three other studies. 33,34,48 Two other studies also did not find an association with parasitemia. 14,35 This may be explained by the fact that differences in our malaria population (all cases were uncomplicated malaria) were too marginal to yield significant differences.…”

Section: Discussionmentioning

confidence: 92%

“…In accordance, previous studies and a recent metaanalysis showed congruent lipid profile changes during malaria infection. [2][3][4][5]7,8,10,11,13,14,24,[32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47] The meta-analysis (2013) was updated with the data of the present study, further strengthening the findings of that study. 7 The extent of these serum lipid profile changes was not related to parasitemia, in contrast to three other studies.…”

Section: Discussionmentioning

confidence: 99%

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Serum Lipids and Lipoproteins During Uncomplicated Malaria: A Cohort Study in Lambaréné, Gabon

Visser

Vries

Vingerling

et al. 2017

The American Society of Tropical Medicine and Hygiene

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Abstract. The serum lipid profile in malaria patients has been found to differ from that of healthy controls. We investigated serum lipid profile changes in malaria patients over time compared with patients with other febrile diseases. In total, 217 patients were included in the study (111 malaria patients and 106 symptomatic controls, defined as malaria-negative febrile patients). Serum lipid levels (mmol/L) were significantly lower in malaria patients compared with those with other febrile diseases (total cholesterol . No significant differences were found for apolipoprotein A1, apolipoprotein B, and lipoprotein(a). Cholesterol levels increased toward reference values on day 28 ( TC = 3.26-3.98, P < 0.001; HDL-C = 0.43-0.96, P < 0.001; LDL-C = 2.05-2.60, P < 0.001). TG levels decreased from 1.81 on admission to 1.76 (day 3) and 0.88 (day 28; P = 0.130). Lipid profile changes were not correlated with parasitemia or Plasmodium falciparum histidine-rich protein 2 levels. This study confirms characteristic temporary lipid profile changes in malaria. Lipid profile changes demonstrated a good accuracy to discriminate between malaria and other febrile diseases (area under the curve = 0.80 (95% confidence interval = 0.742-0.863, P < 0.001). Several plausible hypotheses exist regarding the pathophysiology of lipid profile changes in malaria. Further studies to elucidate the precise pathways may lead to improved understanding of the underlying pathophysiology.[

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Serum Lipids and Lipoproteins During Uncomplicated Malaria: A Cohort Study in Lambaréné, Gabon

Visser

Vries

Vingerling

et al. 2017

The American Society of Tropical Medicine and Hygiene

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“…It has been suggested that PAF could play a pathophysiological role in severe malaria, through activation of platelets [37]. Platelets that are sequestered in cerebral microvessels are thought to be involved in endothelial cell damage and in malaria pathogenesis [1].…”

Section: Discussionmentioning

confidence: 99%

Gene‐Expression Profiling Discriminates between Cerebral Malaria (CM)–Susceptible Mice and CM‐Resistant Mice

et al. 2006

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The development of cerebral malaria (CM) in mice with Plasmodium berghei ANKA infection is under genetic control. Brain gene-expression patterns were investigated in well-defined genetically CM-resistant (CM-R; BALB/c and DBA/2) and CM-susceptible (CM-S; C57BL/6 and CBA/J) mice by use of cDNA microarrays. By combining transcriptional profiling with rigorous statistical methods and cluster analysis, we identified a set of 69 genes that perfectly discriminated between mouse strains and between CM-R and CM-S mice. The analysis of gene ontological terms revealed that the genes that clustered and were related to susceptibility to CM preferentially belonged to some biological process classes, such as those pertaining to immune responses. Using a false discovery rate of 5% and the Welch t test, we identified 31 genes with consistent differential expression between CM-R and CM-S mice. These data indicate that microarray analysis may be useful for identification of candidate genes that are potentially responsible for resistance or susceptibility to mouse CM and suggest that candidate genes identified in mice could be specifically tested in humans for an association with disease severity.

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“…Hypocholesterolemia and hypertriglyceridemia were observed in the setting of both uncomplicated and complicated malaria (Das et al 1996;Davis et al 1993;Mohanty et al 1992;Nilsson-Ehle and Nilsson-Ehle 1990;Ngou-Milama et al 1995) and in the setting of many other acute infections (Bentz and Magnette 1998;Samra et al 1996). The magnitude of these changes seems related to the severity of malaria (Das et al 1996;Mohanty et al 1992).…”

Section: Introductionmentioning

confidence: 90%

The impact of malaria on common lipid parameters

Faucher

Ngou-Milama

Missinou

et al. 2002

Parasitology Research

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No data are available in the literature to indicate whether low-level Plasmodium falciparum infections induce lipid parameter changes. We hypothesized that low-level P. falciparum infections induce significant changes in common lipid parameters. We retrospectively selected samples from a malaria prophylaxis study to measure the impact of sustained parasite clearance on common lipid parameters [total cholesterol (TChol), high-density lipoprotein (HDL)-cholesterol (HDL-c), low-density lipoprotein (LDL)-cholesterol (LDL-c) and triglycerides (TG)] in 47 apparently healthy schoolchildren whose P. falciparum parasitemia was initially below 1000/ microl. After parasite clearance, mean values were significantly increased for Tchol ( P<0.001) and HDL-c ( P<0.001), unlike LDL-c ( P=0.93); and TG were significantly decreased from the baseline ( P=0.004). No significant change was found in a control group. This is the first study showing significant lipid changes related to low-level P. falciparum infections. Further studies are needed to explore the relevance of this finding at the population level in hyperendemic malaria areas.

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Platelet-activating factor and lipid metabolism in acute malaria

Cited by 20 publications

References 13 publications

Serum Lipids and Lipoproteins During Uncomplicated Malaria: A Cohort Study in Lambaréné, Gabon

Serum Lipids and Lipoproteins During Uncomplicated Malaria: A Cohort Study in Lambaréné, Gabon

Gene‐Expression Profiling Discriminates between Cerebral Malaria (CM)–Susceptible Mice and CM‐Resistant Mice

The impact of malaria on common lipid parameters

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