1979
DOI: 10.1016/s0021-9258(19)83523-8
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Platelet-activating factor. Evidence for 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine as the active component (a new class of lipid chemical mediators).

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Cited by 1,149 publications
(138 citation statements)
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“…A key molecule implicated in COVID-19 pathology is platelet activating factor (PAF), as recently highlighted by our group [2,13]. More particularly, PAF is a glyceryl-ether phospholipid (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) [14], which is a potent mediator of inflammation and thrombosis [15,16]. It is produced by various cells such as platelets, endothelial cells, macrophages, monocytes, neutrophils and other cells continuously or upon inflammatory stimuli [15].…”
Section: Introductionmentioning
confidence: 99%
“…A key molecule implicated in COVID-19 pathology is platelet activating factor (PAF), as recently highlighted by our group [2,13]. More particularly, PAF is a glyceryl-ether phospholipid (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) [14], which is a potent mediator of inflammation and thrombosis [15,16]. It is produced by various cells such as platelets, endothelial cells, macrophages, monocytes, neutrophils and other cells continuously or upon inflammatory stimuli [15].…”
Section: Introductionmentioning
confidence: 99%
“…Platelet-activating factor (PAF), a phosphoglycerylether lipid (1-O-alkyl-2-acetyl-snglycero-3-phosphocholine) [2], constitutes a potent inflammatory mediator implicated in a plethora of pathophysiologic conditions, such as atherosclerosis [3], allergic disorders [4], cancer and other diseases. PAF is synthesized by almost all cell types, either at basal conditions or under specific stimuli.…”
Section: Introductionmentioning
confidence: 99%
“…Platelet-activating factor (PAF) 14 is a potent phospholipid mediator with a wide variety of biological activities related to physiological and pathological proinflammatory conditions, such as the atherosclerosis, cancer, renal diseases, AIDS, and so on. [14][15][16][17][18][19][20][21][22][23] Several cell types, such as leukocytes, platelets, macrophages, endothelial cells, and renal cells, can produce PAF under appropriate stimuli. 24 Two distinctive enzymatic biosynthetic routes have been described, the de-novo and the remodelling pathways.…”
Section: Introductionmentioning
confidence: 99%