Platelet activating factor in allergies

Pałgan, Krzysztof; Bartuzi, Zbigniew

doi:10.1177/0394632015600598

Cited by 75 publications

(78 citation statements)

References 38 publications

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“…Eosinophils possess cell surface receptors for lipid mediators such as leukotrienes, prostaglandins, and platelet-activating factor, all of which have been shown to have a role in asthma pathophysiology (12–14). …”

Section: Eosinophil Surface Molecules and Receptorsmentioning

confidence: 99%

The Biology of Eosinophils and Their Role in Asthma

2017

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This review will describe the structure and function of the eosinophil. The roles of several relevant cell surface molecules and receptors will be discussed. We will also explore the systemic and local processes triggering eosinophil differentiation, maturation, and migration to the lungs in asthma, as well as the cytokine-mediated pathways that result in eosinophil activation and degranulation, i.e., the release of multiple pro-inflammatory substances from eosinophil-specific granules, including cationic proteins, cytokines, chemokines growth factors, and enzymes. We will discuss the current understanding of the roles that eosinophils play in key asthma processes such as airway hyperresponsiveness, mucus hypersecretion, and airway remodeling, in addition to the evidence relating to eosinophil–pathogen interactions within the lungs.

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Section: Eosinophil Surface Molecules and Receptorsmentioning

confidence: 99%

The Biology of Eosinophils and Their Role in Asthma

2017

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“…1) is a potent pro-inflammatory and coagulation-inducing phospholipid mediator first identified in basophils by Jacques Benveniste in 1972 [7]. PAF enhances inflammation via immune cell chemotaxis, triggering of de-granulation, and immune cell adhesion to the vascular endothelium [8]. …”

Section: Platelet-activating Factormentioning

confidence: 99%

Lipid Mediators of Allergic Disease: Pathways, Treatments, and Emerging Therapeutic Targets

Schauberger

Peinhaupt

Cazares

et al. 2016

Curr Allergy Asthma Rep

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Bioactive lipids are critical regulators of inflammation. Over the last 75 years, these diverse compounds have emerged as clinically-relevant mediators of allergic disease pathophysiology. Animal and human studies have demonstrated the importance of lipid mediators in the development of asthma, allergic rhinitis, urticaria, anaphylaxis, atopic dermatitis, and food allergy. Lipids are critical participants in cell signaling events which influence key physiologic (bronchoconstriction) and immune phenomena (degranulation, chemotaxis, sensitization). Lipid-mediated cellular mechanisms including: (1) formation of structural support platforms (lipid rafts) for receptor signaling complexes, (2) activation of a diverse family of G-protein coupled receptors, and (3) mediating intracellular signaling cascades by acting as second messengers. Here, we review four classes of bioactive lipids (platelet activating factor, the leukotrienes, the prostanoids, and the sphingolipids) with special emphasis on lipid synthesis pathways and signaling, atopic disease pathology, and the ongoing development of atopy treatments targeting lipid mediator pathways.

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“…In particular, vasoactive compounds such as serotonin, histamine, TNF, heparin and proteases, modulate inflammation and regulate the permeability in several disorders of the CNS [23]. Research efforts in the past decade have highlighted that the activation of mast cells plays a role in neuroinflammation [27]. Alzheimer's disease and autoimmune diseases have increased dramatically over the years.…”

Section: Mast Cellsmentioning

confidence: 99%