1994
DOI: 10.1002/jbmr.5650091114
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Platelet-activating factor induces pseudopod formation in calcitonin-treated rabbit osteoclasts

Abstract: We demonstrated previously that platelet-activating factor (PAF), a potent inflammatory mediator, acts on osteoclasts to elevate cytosolic [Ca2+] and stimulate resorption. However, it is not clear whether the effects of PAF on resorptive activity are direct or indirect. In the present study, we investigated the effects of PAF on osteoclast motility. Osteoclasts were isolated from the long bones of neonatal rabbits, and cell motility and morphology were monitored using time-lapse video microscopy. Calcitonin, a… Show more

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Cited by 12 publications
(2 citation statements)
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“…On the other hand, PAF causes retraction of pseudopods with respreading observed within 30 min (41). Moreover, PAF promotes respreading of lamellipodia in calcitonin-pretreated osteoclasts and stimulates bone resorption (42)(43)(44). Interestingly, the morphological responses observed in LPA-treated osteoclasts are distinct from the responses elicited by either calcitonin or PAF.…”
Section: Numbermentioning
confidence: 93%
“…On the other hand, PAF causes retraction of pseudopods with respreading observed within 30 min (41). Moreover, PAF promotes respreading of lamellipodia in calcitonin-pretreated osteoclasts and stimulates bone resorption (42)(43)(44). Interestingly, the morphological responses observed in LPA-treated osteoclasts are distinct from the responses elicited by either calcitonin or PAF.…”
Section: Numbermentioning
confidence: 93%
“…Nossos resultados indicam que a administração de calcitonina, em animais ovariectomizados, imediatamente após a realização de um defeito ósseo, pode exercer um efeito anabólico direta ou indiretamente sobre esse tecido, já que estudos anteriores demonstraram sua ação sobre os osteoclastos 14,18,24 e, em grau menor, sobre os osteoblastos 18 .…”
Section: Discussionunclassified