Platelet activation: a link between psoriasis<i>per se</i>and subclinical atherosclerosis - a case-control study

Saleh, Hanan; Attia, Enas A. S.; Onsy, Ahmed; Saad, Abeer A.; Ellah, M.M.M. Abd

doi:10.1111/bjd.12285

Cited by 54 publications

(53 citation statements)

References 53 publications

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“…To our knowledge, CD63 or CD42b expression in psoriasis had not been investigated so far. In contrast to our CD62P results, three previous studies have shown enhanced CD62P surface expression in psoriasis[6,9,33]. One other study was in concordance with our findings[34].…”

Section: Discussionsupporting

confidence: 89%

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Increased levels of circulating platelet-derived microparticles in psoriasis: Possible implications for the associated cardiovascular risk

Papadavid

Diamanti

Spathis

et al. 2016

WJC

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AIMTo evaluate platelet activation markers in psoriasis patients, compared to controls, and investigate their association with the inflammatory burden of psoriasis.METHODSForty psoriatic patients without cardiovascular disease, and 12 healthy controls were subjected to measurement of baseline platelet CD62P, CD63 and CD42b expression, platelet-leukocyte complexes, i.e., platelet-monocyte complexes (PMC), platelet-neutrophil complexes (PNC) and platelet-lymphocyte complexes, and concentrations of platelet-derived microparticles (PMPs) using flow cytometry. Both larger-size (0.5-0.9 μm) and smaller-size (< 0.5 μm) PMPs were determined. Serum interleukin (IL)-12 and IL-17 levels were also measured by enzyme-linked immunosorbent assay. The severity of psoriasis was evaluated by the Psoriasis Area Severity Index (PASI).RESULTSPMP concentrations were significantly higher in psoriasis patients than controls [mean ± standard error of mean (SEM): 22 ± 5/μL vs 11 ± 6/μL; P = 0.018), for both smaller-size (10 ± 2/μL vs 4 ± 2/μL; P = 0.033) and larger-size (12 ± 3/μL vs 6 ± 4/μL; P = 0.014) PMPs. Platelet CD62P, CD63 and CD42b expression and circulating PMC and PNC were similar between the two groups. Lower circulating PLC were observed in psoriasis patients compared to controls (mean ± SEM: 16% ± 3% vs 23% ± 6%; P = 0.047). Larger-size PMPs were related with IL-12 levels (P < 0.001) and smaller-size PMPs with both IL-12 and IL-17 levels (P < 0.001). Total PMPs also correlated with IL-12 (P < 0.001). CD63 expression was positively correlated with both IL-12 and IL-17 (P < 0.05). Increased PASI score was associated with increased levels of larger-size PMPs (r = 0.45; P = 0.011) and increased CD63 expression (r = 0.47; P < 0.01).CONCLUSIONPMPs, known to be predictive of cardiovascular outcomes, are increased in psoriasis patients, and associated with high inflammatory disease burden. Enhanced platelet activation may be the missing link leading to cardiovascular events in psoriatic patients.

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Section: Discussionsupporting

confidence: 89%

“…Pathomechanisms of psoriasis involve platelet activation, as reported by several investigators so far[6-9]. Increased platelet activation is also implicated in atherosclerotic plaque formation and plaque destabilization[10,11].…”

Section: Introductionmentioning

confidence: 95%

Increased levels of circulating platelet-derived microparticles in psoriasis: Possible implications for the associated cardiovascular risk

Papadavid

Diamanti

Spathis

et al. 2016

WJC

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“…Tamagawa-Mineoka et al found a correlation between platelet activation indicators and PASI scores in their studies on psoriasis patients that have shown platelet activation [26]. However, Saleh et al could not find a statistically significant difference in MPV in either the patient or control groups, unlike in other studies [27]. Recently, Kim et al indicated that a positive correlation between PASI and MPV as a result of their studies indicate higher MPV levels in moderate to severe psoriasis patients (PASI ≥ 10) than mild psoriasis (PASI < 10) groups.…”

Section: Discussionmentioning

confidence: 96%

Association between mean platelet volume and disease severity in patients with psoriasis and psoriatic arthritis

Kılıç¹,

Reşorlu²,

Işık³

et al. 2017

pdia

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IntroductionMean platelet volume (MPV) is an important marker that shows the activation and function of the platelets, which is effective in the inflammatory diseases.AimTo show the relationship between MPV and the development of psoriatic arthritis (PA) in patients with psoriasis vulgaris (PV) and the correlation between MPV and psoriasis severity score (PASI).Material and methodsOur study included 116 patients with psoriatic arthritis (68 female, 48 male) and 41 patients in the psoriasis group (19 female, 22 male) and 90 subjects in the control group (55 female, 35 male). The demographic data of the patients, duration of disease, PASI, the nature of the disease were evaluated retrospectively.ResultsMean platelet volume levels of both the PV group (8.79 ±0.86 fl) and the PA group (9.18 ±1.26 fl) were significantly higher compared to the control group (8.42 ±0.74 fl). There was a weak statistically positive correlation between the PASI and the MPV according to the correlation analysis (r = 0.165; p = 0.046).ConclusionsOur results show that MPV may be helpful as an indicator of the clinical course of PV and PA. In this regard, that study should be supported by prospective studies to find strong correlations.

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“…Saleh et al . investigated platelet markers that may be associated with subclinical atherosclerosis in patients with psoriasis [22]. However, the researchers did not find a significant difference in the MPV values of patients with psoriasis.…”

Section: Discussionmentioning

confidence: 99%

The correlation between the psoriasis area severity index and ischemia-modified albumin, mean platelet volume levels in patients with psoriasis

Işık¹,

Kılıç²,

Öğretmen³

et al. 2016

pdia

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IntroductionIschemia-modified albumin (IMA), a novel ischemia marker, and mean platelet volume (MPV), a determinant of platelet activation, have been reported as elevated markers in cardiovascular risk factors such as atherosclerosis, metabolic syndrome, diabetes mellitus (DM), hypertension, and dyslipidemia. As psoriasis is a chronic inflammatory disease having comorbidities, IMA and MPV can help determine the risk factors for psoriasis.AimTo investigate the correlation between the psoriasis area severity index (PASI), IMA and MPV levels in patients with psoriasis.Material and methodsThis cross-sectional, case-control study was performed between January 2014 and December 2014 at the University hospital in Çanakkale, Turkey. Forty-five patients with psoriasis and 44 healthy volunteers over 18 years of age were included in the study. In the psoriasis patient group, clinical features and PASI scores were recorded. Serum IMA and MPV concentrations were evaluated in both groups.ResultsThe mean IMA values were 0.85 ±0.15 and 0.79 ±0.09 (in the psoriasis patients and control groups, respectively), and there was a statistically significant difference (p = 0.048). Ischemia-modified albumin levels were not correlated with PASI scores (r = 0.024; p = 0.889) but were correlated with disease duration (r = 0.323; p = 0.048). There was no statistically significant difference between the MPV values of the two groups (8.98 ±1.14 and 9.19 ±1.28 in the psoriasis patients and control groups, respectively) (p = 0.435).ConclusionsIschemia-modified albumin may be used as a marker for detecting oxidative stress in patients with psoriasis, especially those with a long disease duration.

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Platelet activation: a link between psoriasisper seand subclinical atherosclerosis - a case-control study

Cited by 54 publications

References 53 publications

Increased levels of circulating platelet-derived microparticles in psoriasis: Possible implications for the associated cardiovascular risk

Increased levels of circulating platelet-derived microparticles in psoriasis: Possible implications for the associated cardiovascular risk

Association between mean platelet volume and disease severity in patients with psoriasis and psoriatic arthritis

The correlation between the psoriasis area severity index and ischemia-modified albumin, mean platelet volume levels in patients with psoriasis

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