Platelet activation and function in response to high intensity interval exercise and moderate continuous exercise in CABG and PCI patients

Ahmadizad, Sajad; Nouri-Habashi, Akbar; Rahmani, Hiwa; Maleki, Majid; Naderi, Nasim; Lotfian, Sara; Salimian, Morteza

doi:10.3233/ch-168010

Cited by 14 publications

(11 citation statements)

References 31 publications

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“…In the study by Ahmadizad et al highintensity interval training was found to be higher in patients who underwent new revascularization than in those with continuous revascularization. 28 In our study, while the CRP value did not differ signifi-cantly, we see that the ESR value has decreased. Exercise program has a positive effect to CVS disease by decreasing inflammation.…”

Section: Discussioncontrasting

confidence: 39%

Effect of Home-Based Aerobic Exercise Program on Bleeding Profile and Inflammation in Patients with Behçet's Disease

Koca¹,

Seyithanoğlu²,

Nazik³

et al. 2020

J PMR Sci

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ABS TRACT Objective: Sedentary lifestyle is a major risk factor for cardiovascular disease (CVS) and thrombotic complications. The effect of different types of exercise on platelet function has been the subject of a limited number of studies. Behçet's disease is a multisystemic disease characterized by recurrent oral and genital aphthous lesions and uveitis with unknown etiology. There is an unknown cause of the disease and hyperactivation of the procoagulant cascade and associated mortality due to arterial and venous thrombosis. Here, the effect of aerobic exercise on the bleeding profile and acute phase reactants in Behçet's patients was analyzed experimentally. Material and Methods: Twenty-four (n=24) patients with Behcet's disease were included in the study. Age, height, weight, sex, smoking, known systemic disease (such as diabetes, hypertension, thyroid) and vascular claudication were investigated. Those who didn't complete the protocole (n=5) were excluded from the study. Before and after moderate intensity aerobic exercise program (4 weeks, 3 times a week, 45 minutes per day) sedimentation (ESR), C-reactive protein (CRP), bleeding profile including prothrombin time (PT), prothrombin time percentage (PT%), activated prothrombin time (aPTT), platelet, collagen epinephrine, collagen adenosine diphosphate (ADP) and international normalized ratio (INR) were recorded. Results: Nineteen patients with Behçet's disease were enrolled. The mean age was 37.8±9.8 years. The mean body mass index (BMI) was 28.6±5.5 kg/m 2. Vascular claudication was present in 9 patients (47.4%), smoking in 1 patient (5.3%), and hypertension (10.5%) in 2 patients. While ESR (p=0.028) and collagen ADP (p=0.02) decreased after exercise; platelet count (p=0.005), aPTT (p=0.08), PT (p=0.022) and PT% (p=0.014) were increased. Conclusion: Increase in the duration of aggregation and decrease in inflammation after the exercise program supports that thrombosis can be prevented by exercise. We conclude that short term home-based aerobic exercise program has positive effect on homeostasis in patients with Behçet's disease.

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Section: Discussioncontrasting

confidence: 39%

Effect of Home-Based Aerobic Exercise Program on Bleeding Profile and Inflammation in Patients with Behçet's Disease

Koca¹,

Seyithanoğlu²,

Nazik³

et al. 2020

J PMR Sci

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“…[44][45][46] The increase in factor VIII and the degree of platelet activation and aggregation after exercise are associated with the intensity of the exercise. [47][48][49] Furthermore, the degree of platelet activation after HIT is reported to be related to individual physical fitness, leaving untrained individuals in at higher risk than well-trained individuals. 43 4. them more prone to TE events.…”

Section: The Association Of Hit and Te Riskmentioning

confidence: 99%

Thromboembolic events after high‐intensity training during cisplatin‐based chemotherapy for testicular cancer: Case reports and review of the literature

Thorsen

Haugnes

Fosså

et al. 2020

Intl Journal of Cancer

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The randomized "Testicular cancer and Aerobic and Strength Training trial" (TASTtrial) aimed to evaluate the effect of high-intensity interval training (HIIT) on cardiorespiratory fitness during cisplatin-based chemotherapy (CBCT) for testicular cancer (TC). Here, we report on an unexpected high number of thromboembolic (TE) events among patients randomized to the intervention arm, and on a review of the literature on TE events in TC patients undergoing CBCT. Patients aged 18 to 60 years with a diagnosis of metastatic germ cell TC, planned for 3 to 4 CBCT cycles, were randomized to a 9 to 12 weeks exercise intervention, or to a single lifestyle counseling session. The exercise intervention included two weekly HIIT sessions, each with 2 to 4 intervals of 2 to 4 minutes at 85% to 95% of peak heart rate. The study was Abbreviations: AEs, adverse events; (B)EP, (bleomycin) etoposide and cisplatin; CBCT, cisplatin-based chemotherapy; CPET, cardiopulmonary exercise test; CRF, cardiorespiratory fitness; CT, computed tomography; dRVVT, diluted Russell's viper venom test; DXA, dual-energy X-ray absorptiometry; HI(I)T, high-intensity (interval) training; HR, heart rate; RCT, randomized controlled trial; TAST, testicular cancer and aerobic-and strength training; TC, testicular cancer; TE, thromboembolic events.

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“…Low levels of cardiorespiratory fitness are associated with platelet hyper-reactivity, and endurance training affects platelet function in terms of normalisation 10. In addition, acute, strenuous exercise causes transient platelet hyper-reactivity,11 which constitutes an underlying mechanism for triggering myocardial infarctions by physical exertion 12. In this regard, evidence suggests that regular exercise training performed over several weeks can diminish transient platelet hyper-reactivity after acute exertion in healthy individuals 13…”

Section: Introductionmentioning

confidence: 99%

Effects of high-intensity interval training on platelet function in cardiac rehabilitation: a randomised controlled trial

Heber

Fischer

Sallaberger-Lehner³

et al. 2019

Heart

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ObjectiveTo compare effects of moderate-intensity continuous training (MICT) and high-intensity interval training (HIIT) on platelet function in patients undergoing cardiac rehabilitation, as hyper-reactive platelets are involved in atherogenesis and atherothrombosis.MethodsIn this single-centre parallel group randomised controlled trial, male patients after an acute coronary syndrome under dual antiplatelet therapy performed MICT or HIIT+MICT for 12 weeks. Main outcome was platelet reactivity measured by the half-maximal concentration (EC50) of platelet agonist thrombin receptor-activating peptide-6 (TRAP-6) in terms of P-selectin expression. EC50 was determined at baseline, after 6 and 12 weeks, each time at physical rest and on exertion.Results82 patients were randomised to MICT or HIIT+MICT. Mean (95% CI) baseline EC50values at physical rest were 6.7 µM (6.3 µM to 7.0 µM) TRAP-6. After 6/12 weeks, 36/33 MICT and 34/28 HIIT+MICT patients were examined. HIIT+MICT patients had 0.9 µM (0.4 µM to 1.4 µM)/0.5 µM (−0.1 µM to 1.0 µM) higher EC50values than MICT ones, and the propensity of their platelets to form aggregates with monocytes was significantly lower after 12 weeks. Short-term strenuous physical exertion was generally associated with platelet activation and an EC50reduction of 0.7 µM (0.6 µM to 0.8 µM). HIIT+MICT patients tended to be fitter after 12 weeks. No serious harms were observed.ConclusionsIncluding HIIT in cardiac rehabilitation seems to confer additional benefits compared with MICT alone, which should be confirmed in clinical trials with hard endpoints. Exertion-induced platelet activation and hyper-reactivity occur despite dual antiplatelet therapy.Trial registration numberNCT02930330; Results.

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Platelet activation and function in response to high intensity interval exercise and moderate continuous exercise in CABG and PCI patients

Abstract: Based on the findings of the present study it could be concluded that the risk of exercise-induced thrombosis is higher during HIIE than MCE in patients with recent revascularization.

Cited by 14 publications

References 31 publications

Effect of Home-Based Aerobic Exercise Program on Bleeding Profile and Inflammation in Patients with Behçet's Disease

Effect of Home-Based Aerobic Exercise Program on Bleeding Profile and Inflammation in Patients with Behçet's Disease

Thromboembolic events after high‐intensity training during cisplatin‐based chemotherapy for testicular cancer: Case reports and review of the literature

Effects of high-intensity interval training on platelet function in cardiac rehabilitation: a randomised controlled trial

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