Platelet Adhesiveness and Thrombosis in Rabbits on an Atherogenic Diet

Dietary Fats and Arterial Thrombosis

“…M athues et al [78] fed rabbits either a stock diet as such or supple mented with 6 % coconut oil and 2 % cholesterol for 3-7 weeks. Platelet ad hesiveness determined in native platelet-rich plasma (glass bead test) was significantly higher in the supplemented group than in the control group.…”

“…M athues et al [78] used the same technique in rabbits that were fed a stock diet as such or supplemented with 6 % coconut oil and 2 % cholesterol. The enrichement significantly increased the amount of thrombotic deposits, which could be prevented by intravenous infusion of phosphatidyl serine, 30 min prior to the experiment.…”

“…Another factor might be the widespread assumption that decreasing platelet stickiness is sufficient to retard or prevent thrombus formation. There is, however, increasing ex perimental evidence that this concept is too simple [45,78,103] and that, consequently, models for experimental thrombosis are indispensable in thrombosis research. The lack of suitable in vivo techniques might be a third factor to account for the scanty attention paid to experimental arterial thrombosis.…”