Platelet and White Blood Cell Counts Are Elevated in Patients With the Metabolic Syndrome

Jesri, Ammar; Okonofua, Eni C.; Egan, Brent M.

doi:10.1111/j.1524-6175.2005.04809.x

Cited by 84 publications

(77 citation statements)

References 53 publications

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“…In fact, every risk factor and/or clinical symptom associated with the metabolic syndrome including insulin resistance (Anfossi et al, 2003), vascular inflammation (Esposito et al, 2004), dyslipidemia (Arruzazabala et al, 2002), hypertension (Serebruany et al, 2006), and obesity (Anfossi et al, 2004) may per se cause platelet activation. As a combination of the above-mentioned features, the metabolic syndrome obviously represents a high-risk thrombophilic state because of the activation of primary platelet hemostasis (Arteaga et al, 2006;Jesri et al, 2005), hypercoagulation (Nieuwdorp et al, 2005), and impaired fibrinolysis (Trost et al, 2006). The present data are indirectly in agreement with the concept of platelet hyperactivity in patients with the metabolic syndrome based on the fact that it takes higher doses of ESC to exhibit antiplatelet efficacy in these patients than in normal volunteers.…”

Section: Discussionsupporting

confidence: 80%

Antiplatelet Properties of Escitalopram in Patients with the Metabolic Syndrome: A Dose-Ranging In Vitro Study

Atar

Malinin

Pokov

et al. 2007

Neuropsychopharmacol

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There is an increasing body of evidence suggesting that selective serotonin reuptake inhibitors exhibit clinical benefit beyond treating depression, by simultaneously inhibiting platelet activity. We recently demonstrated that escitalopram (ESC), but not its major metabolites, inhibits multiple platelet biomarkers in healthy volunteers. Considering that the metabolic syndrome represents one of the major risk factors for vascular disease, we here determined how ESC affects platelet activity in such patients. We assessed the in vitro effects of preincubation with escalating (50-200 nM/l) concentrations of ESC on platelet aggregation, expression of major surface receptors by flow cytometry, and quantitatively by platelet function analyzers. Blood samples were obtained from 20 aspirin-naïve patients with documented metabolic syndrome. Pretreatment of blood samples with medium (150 nM/l), or high (200 nM/l) doses of ESC resulted in a significant inhibition of platelet aggregation induced by ADP (p ¼ 0.007) and by collagen (p ¼ 0.004). Surface platelet expression of GPIb (CD42, p ¼ 0.03), LAMP-3 (CD63, p ¼ 0.04), and GP37 (CD165, p ¼ 0.03) was decreased in the ESC-pretreated samples. Closure time by the PFA-100 analyzer was prolonged after the 200 nM/l dose (p ¼ 0.02), indicating platelet inhibition under high shear conditions. On the other hand, the lowest tested concentration of ESC (50 nM/l) did not affect platelet activity in these patients. The in vitro antiplatelet characteristics of ESC in patients with the metabolic syndrome are similar to those in healthy volunteers. However, higher ESC doses are required to induce equally potent platelet inhibition. These data justify prospective ex vivo studies with the highest therapeutic dose to determine the potential clinical advantage of ESC in high-risk patients with vascular disease.

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Section: Discussionsupporting

confidence: 80%

Antiplatelet Properties of Escitalopram in Patients with the Metabolic Syndrome: A Dose-Ranging In Vitro Study

Atar

Malinin

Pokov

et al. 2007

Neuropsychopharmacol

View full text Add to dashboard Cite

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“…The cross sectional nature of the study is one of the main limitations, which makes it difficult to determine the causality with respect to observed relationships. In addition, as physical activity can also change the number of platelets proportional to the number of platelets and the number of leukocytes, C-reactive protein, fibrinogen, blood viscosity, factor VIII and IX, von Willebrand factor, dimer D of fibrin and the tissue plasminogen activator antigen [29].…”

Section: Discussionmentioning

confidence: 99%

Association Between Obesity, White Blood Cell and Platelet Count

Jamshidi

Seif

2017

Zahedan J Res Med Sci

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Background: Cardiovascular disease is resulted from malfunctioning's of heart as well as blood vessels. More than two decades ago it was noted that the number of white blood cells can be an indicated of the existence of such disease. Platelet activation and aggregation are among the include processes. That are considered in pathophysiology of a coronary heart disease. However there seems to be a paucity of research on platelet count in patients suffering from obesity. Moreover although previous studies have indicated a positive correlation between platelet and white blood cells. Counts and mortality from coronary heath disease, how this might correlate with obesity is an issue still in need of more attention. Objectives: The present study was designed to evaluate platelet count and white blood cell count in those patients who suffer from obesity as compared with control subjects who were not obese. Methods: In this cross-sectional study, there were a total of 1024 Iranian subjects living in Hamedan include, staff of Islamic Azad University of Hamedan and subjects who referred to Ekbatan hospital in Hamedan during the period of 6 months randomly and staff of Islamic Azad University of Hamedan. The absence of infectious disease was confirmed by a general practitioner. Finally, the samples included 486 subjects, 254 male, and 232were females. Body mass index was calculated. Waist circumference in the Iranian subjects, at least in men 89 (cm) and women 91 (cm) was considered. White blood cell and platelet count was measured. T-test and Pearson's correlation were run to analyze the collected data through SPSS software version 16.

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“…Um estudo de base populacional em Taiwan descobriu que a presença de um maior número de glóbulos brancos (GB) e de glóbulos vermelhos (GV) aumentou o odds ratio (OR) para o agrupamento de fatores de risco cardiometabólicos 5 . Sugere-se que essa mesma associação ocorra também entre a contagem de plaquetas e GB e o agrupamento de fatores de risco cardiometabólicos 6 . Da mesma forma, a associação de parâmetros hematológicos, particularmente GB, com fatores de risco cardiometabólicos está documentada em crianças e adolescentes 7,8 .…”

Section: Introductionunclassified

Association of air pollution and hematologic parameters in children and adolescents

Poursafa¹,

Kelishadi²,

Amini³

et al. 2011

J Pediatr (Rio J)

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Objective: To assess the relationship of air pollution and hematologic parameters in a population-based sample of children and adolescents. Methods:This cross-sectional study was conducted in 2009-2010 among school students randomly selected from different areas of Isfahan city, the second largest and most air-polluted city in Iran. The association of air pollutants levels with hemoglobin, platelets, red and white blood cells (RBC and WBC, respectively) levels was determined by multiple linear and logistic regression analyses, after adjustment for age, gender, anthropometric measures, meteorological factors, and dietary and physical activity habits. Results:The study participants consisted of 134 students (48.5% boys) with a mean age of 13.10±2.21 years. While the mean Pollutant Standards Index (PSI) was at moderate level, the mean particulate matter ≤ 10 µm (PM 10 ) was more than twice the normal level. Multiple linear regression analysis showed that PSI and most air pollutants, notably PM 10 , had significant negative relationship with hemoglobin and RBC count, and positive significant relationship with WBC and platelet counts. The odds ratio of elevated WBC increased as the quartiles of PM 10 , ozone and PSI increased, however these associations reached to significant level only in the highest quartile of PM 10 and PSI. The corresponding figures for hemoglobin and RBC were in opposite direction. Conclusions:The association of air pollutants with hematologic parameters and a possible pro-inflammatory state is highlighted. The presence of these associations with PM 10 in a moderate mean PSI level underscores the necessity to re-examine environmental health policies for the pediatric age group.J Pediatr (Rio J). 2011;87(4): Air pollution, cell blood count, atherosclerosis, inflammation, children, prevention. ResumoObjetivo: Avaliar a relação entre poluição atmosférica e parâ-metros hematológicos em uma amostra populacional de crianças e adolescentes. Métodos:Este estudo transversal foi realizado em 2009-2010 com estudantes escolhidos aleatoriamente de diversas áreas de Isfahan, a segunda maior e mais poluída cidade iraniana. A associação entre os níveis de poluentes do ar e os de hemoglobina, plaquetas, glóbulos brancos (GB) e glóbulos vermelhos (GV) foi determinada pelas análises linear múltipla e de regressão logística ajustadas para idade, sexo, medidas antropométricas, fatores meteorológicos, e hábitos alimentares e de atividade física. Resultados:Participaram do estudo 134 estudantes (48,5% meninos), com idade média de 13,10±2,21 anos. Com níveis moderados de Pollutant Standards Index (PSI), a média de material particulado (particulate matter) ≤ 10 µm (PM 10 ) foi mais do que o dobro do normal. A análise de regressão linear demonstrou que o PSI e a maioria dos poluentes atmosféricos, especialmente PM 10 , estiveram negativamente relacionados com a contagem de hemoglobina e GV e positivamente relacionados com a contagem de GB e plaquetas. O odds ratio de uma elevação nos GB aumentou conforme os quart...

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Platelet and White Blood Cell Counts Are Elevated in Patients With the Metabolic Syndrome

Cited by 84 publications

References 53 publications

Antiplatelet Properties of Escitalopram in Patients with the Metabolic Syndrome: A Dose-Ranging In Vitro Study

Antiplatelet Properties of Escitalopram in Patients with the Metabolic Syndrome: A Dose-Ranging In Vitro Study

Association Between Obesity, White Blood Cell and Platelet Count

Association of air pollution and hematologic parameters in children and adolescents

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