Platelet and white blood-cell-based ratios: Differential inflammatory markers of severe mental disorders?

Paniagua, Gonzalo; González-Blanco, Leticia; Sáiz, Pilar A.; Moya-Lacasa, Carlota; Gutiérrez, Laura; Martínez-Botía, Patricia; Dal Santo, Francesco; Jiménez-Treviño, Luis; García-Portilla, María Paz; Bobes, Julio

doi:10.1016/j.sjpmh.2023.03.002

Spanish Journal of Psychiatry and Mental Health

2023

DOI: 10.1016/j.sjpmh.2023.03.002

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Platelet and white blood-cell-based ratios: Differential inflammatory markers of severe mental disorders?

Gonzalo Paniagua,

Leticia González-Blanco,

Pilar A. Sáiz

et al.

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2024

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Neutrophil-to-Lymphocyte Ratio Any Association with Metabolic Syndrome in Schizophrenia

Zakharova,

Nasyrova,

Rakhmatullin

et al. 2024

jour

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To date, hematologic inflammation coefficients (HICs) have been considered as biological markers linking the functions of the immune, endocrine, and autonomous nervous systems. HICs are markers of immune abnormalities that accompany various pathologic conditions and, to a large extent, determine disease prognosis, survival time, and function. According to the results of a meta-analysis covering the results of examination of more than 168 thousand patients, it was found that the ratio of neutrophils to lymphocytes (NLR) is associated with higher levels in patients with metabolic syndrome and can potentially be used for early detection of this pathology. Given these facts, it seems reasonable to test the assumption of the role of HICs in the pathogenesis of psychiatric disorders, their participation in the mechanisms of development of comorbid conditions, or predicting the outcome and effects of therapy. In 2024, the team of the Bekhterev Center began to perform work under the state assignment of the Ministry of Health of the Russian Federation, the purpose of which was to develop and validate a model for predicting individual risks of metabolic disorders in patients with psychiatric disorders, on the basis of which interpretive software will be presented. The team of authors of this article focused on conducting a systematic review of publications to test this hypothesis.

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Neutrophil-to-Lymphocyte Ratio Any Association with Metabolic Syndrome in Schizophrenia

Zakharova,

Nasyrova,

Rakhmatullin

et al. 2024

jour

View full text Add to dashboard Cite

show abstract

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Platelet and white blood-cell-based ratios: Differential inflammatory markers of severe mental disorders?

Cited by 1 publication

References 36 publications

Neutrophil-to-Lymphocyte Ratio Any Association with Metabolic Syndrome in Schizophrenia

Neutrophil-to-Lymphocyte Ratio Any Association with Metabolic Syndrome in Schizophrenia

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