Platelet Angiotensin II Binding Sites and Early Detection of Preeclampsia

Pouliot, L.; Forest, Jean‐Claude; Moutquin, Jean‐Marie; Coulombe, Nadine; Massé, Jacques

doi:10.1097/00006250-199804000-00021

Cited by 3 publications

(3 citation statements)

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“…In normotensive pregnancy platelet angiotensin II binding falls from non-pregnant levels, often reaching undetectable lev-els during mid-trimester, followed by a significant rise in binding after delivery. These data are broadly in agreement with the findings of two other studies (Pouliot et al, 1998;Broughton-Pipkin et al, 1998). These data are broadly in agreement with the findings of two other studies (Pouliot et al, 1998;Broughton-Pipkin et al, 1998).…”

Section: Introductionsupporting

confidence: 93%

Platelet angiotensin II binding may be a useful prognostic indicator for the development of pre-eclampsia in women with pregnancy-induced hypertension: preliminary communication

O’Brien

Walker²

2001

Journal of Obstetrics and Gynaecology

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This was a preliminary investigation to assess the value of platelet angiotensin II binding as a prognostic indicator for subsequent pre-eclampsia in women admitted with non-proteinuric pregnancy-induced hypertension. Platelet angiotensin II binding was measured in 26 women at the onset of their symptoms. All were primparous, had singleton pregnancies, were normotensive at booking and had an unremarkable medical history. The blood pressure of seven women resolved and returned to normal; 11 women remained stable throughout the remainder of their pregnancy, their blood pressure remained elevated but they did not develop significant proteinuria. Eight women developed pre-eclampsia. Platelet angiotensin II binding in the pre-eclamptic group was significantly higher compared to those who remained stable (P = 0.042) or those whose condition improved (P = 0.021). We conclude that angiotensin II binding measured at the time of admission to hospital for non-proteinuric pregnancy-induced hypertension may have a role in predicting the onset of pre-eclampsia or eclampsia.

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Section: Introductionsupporting

confidence: 93%

Platelet angiotensin II binding may be a useful prognostic indicator for the development of pre-eclampsia in women with pregnancy-induced hypertension: preliminary communication

O’Brien

Walker²

2001

Journal of Obstetrics and Gynaecology

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“…Finally, the penultimate pair of papers on pre-eclampsia and pregnancy disagree, with one recommending angiotensin II, showing a difference in the third trimester [83] (lower in pre-eclampsia, P < 0.05) but not with platelet angiotensin [84]. Also, plasma active renin, which is not limiting to angiotensin, is not protective in the third trimester, but aldosterone is [83].…”

Section: Discussionmentioning

confidence: 99%

Persistant pre-eclampsia post partum with elevated liver enzymes and hemolytic uremic syndrome

et al. 1999

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“…Furthermore elevated platelet angiotensin-II binding has been observed in singleton pregnancies complicated by preeclampsia [23,24].…”

Section: Discussionmentioning

confidence: 99%

Comparative Analysis of the Angiotensin-II Receptor in Placental Vascular Endothelial Cells in Preeclamptic and Normotensive Patients

Laskowska

Vinson

Szumiło³

et al. 2003

Gynecol Obstet Invest

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The aim of this study was to compare the immunoreactivity of angiotensin-II receptor type 1 (AT1R) in the vascular endothelial cells of human placental vessels in normal and preeclamptic pregnancies. Immunohistochemistry was used to examine the localization of AT1R in the vascular endothelium of human placental vessels. In preeclamptic patients without intrauterine growth retardation (IUGR) the mean histological index H score was significantly higher, but significantly decreased in patients with preeclampsia complicated by IUGR in comparison with the control group. Immunolocalization of AT1R in vascular endothelial cells in our study supports the view that angiotensin II may play a role in the regulation of vascular tone and vascular resistance and the actions of other vasoactive factors, vasodilators or vasoconstrictors. However, our results confirmed that AT1R immunoreactivity is elevated in vascular endothelial cells of human placenta from pregnancies complicated by preeclampsia, suggesting a higher activity of the renin-angiotensin-aldosterone system (RAAS) in women with preeclampsia. On the other hand reduced immunoreactivity of AT1R in placental vascular endothelial cells in pregnancy complicated by preeclampsia with IUGR may result from chronic higher RAAS activity and may suggest the decreased ability to compensate and the inability to restore the normal balance between vasodilators and vasoconstrictors. These results may also reflect destructive changes and dysfunction of the vascular endothelium in preeclamptic pregnancy with IUGR.

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Platelet Angiotensin II Binding Sites and Early Detection of Preeclampsia

Cited by 3 publications

References 0 publications

Platelet angiotensin II binding may be a useful prognostic indicator for the development of pre-eclampsia in women with pregnancy-induced hypertension: preliminary communication

Platelet angiotensin II binding may be a useful prognostic indicator for the development of pre-eclampsia in women with pregnancy-induced hypertension: preliminary communication

Persistant pre-eclampsia post partum with elevated liver enzymes and hemolytic uremic syndrome

Comparative Analysis of the Angiotensin-II Receptor in Placental Vascular Endothelial Cells in Preeclamptic and Normotensive Patients

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