Platelet-associated parameters in patients with psoriasis

Abstract

Background: The relationship between platelet-associated parameters and psoriasis has been controversial. The purpose of our meta-analysis was to assess whether platelet count, platelet-to-lymphocyte ratio (PLR), mean platelet volume (MPV), and platelet distribution width (PDW) are associated with psoriasis.Methods: We performed a thorough documentation retrieval via PubMed, EMBASE, and Web of Science until June 2021. Pooled standardized mean differences (SMDs) and 95% confidence intervals (CIs) were calculated using a random-effects model.Results: Overall, 22 studies involving 1749 patients with psoriasis and 1538 healthy controls were selected for the meta-analysis. The outcomes showed that platelet count presented non-significant differences between psoriatic patients and normal individuals (SMD = 0.12, 95% CI = À0.07 to 0.32, P = .210), while PLR (SMD = 0.28, 95% CI = 0.03-0.53, P = .031), MPV (SMD = 0.55, 95% CI = 0.30-0.79, P < .001), and PDW (SMD = 0.29, 95% CI = 0.03-0.55, P = .027) were remarkably greater in the psoriatic patients than in the healthy individuals, and similar results were found in subgroup analyses. The analytical results of susceptibility revealed that the outcomes were robust, and no evidence of substantial publication bias was identified.Conclusion: Patients with psoriasis present significantly higher PLR, MPV, and PDW than healthy individuals, suggesting that psoriasis is accompanied by low-grade systemic inflammation and platelet activation.Abbreviations: CI = confidence interval, MPV = mean platelet volume, NOS = Newcastle-Ottawa Quality Assessment Scale, PASI = the Psoriasis Area and Severity Index, PDW = platelet distribution width, PLR = platelet-to-lymphocyte ratio, PLT = platelet count, REM = random-effects model, SMD = standardized mean difference.

The association between platelet indices and presence and severity of psoriasis: a systematic review and meta-analysis

“…Our study extends the findings of a recent meta-analysis by Li et al (2021) of 22 studies including 3287 patients which found that higher MPV and PDW, but not PLT, were associated with presence of psoriasis [ 67 ]. The discrepancies between PLT and PDW conclusions between studies is likely attributable to differences in number of included studies; indeed, our meta-analyses were able to include all 22 studies reported by Li et al as well as an additional 11 relevant studies to investigate platelet indices in both presence and severity of psoriasis.…”

Evaluation of Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio and Mean Platelet Volume in Pediatric Psoriasis Patients: A Descriptive Study

“…It was found that PLR, MPV and platelet distribution width were significantly higher in the patient group compared to the control group, which may indicate low-grade systemic inflammation and platelet activation in patients with psoriasis. 20 In some studies, NLR, PLR and MPV were found related or correlated with the disease severity or activity in adult psoriasis. [11][12][13]21 In our study, there was no significant correlation or relationship between PASI score and laboratory parameters in plaque type pediatric psoriatic patients.…”

Psoriasis increases retinal vein occlusion risk in diabetic patients: A nationwide population-based study

“…Patients with psoriasis exhibit significantly increased platelet activation. 20 Platelets, in addition to their role in hemostasis, have multiple functions related to inflammation, immune responses, and endothelial damage that can contribute to the formation of atherosclerotic plaques or thrombotic complications. [21][22][23] In psoriasis, platelets play a crucial role in disease pathogenesis by activating leukocyte migration to the skin and releasing various pro-inflammatory cytokines.…”

“…24,25 During immune-mediated inflammatory responses, activated platelets interact with leukocytes, leading to the release of a high concentration of cytokines, chemokines, and growth factors. 20,26 This platelet-leukocyte interaction and subsequent excessive release of cytokines and chemokines may trigger leukocyte infiltration into the skin, a hallmark feature of psoriasis. 27,28 Platelet activation and changes in platelet count, volume, and size, such as mean platelet volume and platelet distribution width, serve as indicators of platelet activation.…”