Platelet-Bacterial Interactions as Therapeutic Targets in Infective Endocarditis

Kerrigan, Steven W.; Cox, Dermot

doi:10.5772/28466

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Infective Endocarditis1

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Cited by 2 publications

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“…The significant role for platelets in the development of infected thrombi suggests a role for anti-platelet agents in managing patients with IE (168,169). However, the data have been mixed.…”

Section: Infective Endocarditismentioning

confidence: 99%

Sepsis – it is all about the platelets

Cox

2023

Front. Immunol.

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Sepsis is accompanied by thrombocytopenia and the severity of the thrombocytopenia is associated with mortality. This thrombocytopenia is characteristic of disseminated intravascular coagulation (DIC), the sepsis-associated coagulopathy. Many of the pathogens, both bacterial and viral, that cause sepsis also directly activate platelets, which suggests that pathogen-induced platelet activation leads to systemic thrombosis and drives the multi-organ failure of DIC. In this paper we review the mechanisms of platelet activation by pathogens and the evidence for a role for anti-platelet agents in the management of sepsis.

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Section: Infective Endocarditismentioning

confidence: 99%