Platelet Characteristics Change With Aging: Role of Estrogen Receptor

Jayachandran, Muthuvel; Karnicki, Krzysztof; Miller, Randall S.; Owen, Whyte G.; Korach, Kenneth S.; Miller, Virginia M.

doi:10.1093/gerona/60.7.815

Cited by 35 publications

(32 citation statements)

References 29 publications

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“…Notably, ATP concentration in trophocytes and fat cells have also been shown to decrease with advancing age in worker bees reared in a thermostatic chamber at 34°C (Hsu and Chan 2011a), providing further support for the idea that young and old workers reared in a field hive can be used for studying aging. This decrease in ATP concentration in trophocytes and fat cells of older workers is also consistent with previous studies showing that ATP levels decrease with advancing age in the gastric mucosa and muscle of humans (Kawano et al 1991;Conley et al 2000;Petersen et al 2003;Gurd et al 2008), the blood and brains of mice (Jayachandran et al 2005;Joo et al 1999), the erythrocytes of rabbits (Subasinghe and Spence 2008) and cows (Bartosz et al 1982), and the hearts of rats (Guerrieri et al 1996). This finding is also consistent with the results of ΔΨm measurements reported in this study; as was the case for NAD + , a decrease in ΔΨm can result in a decrease in ATP concentration.…”

Section: δψMsupporting

confidence: 92%

Changes in mitochondrial energy utilization in young and old worker honeybees (Apis mellifera)

Chuang

Hsu

2012

AGE

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Trophocytes and fat cells in honeybees (Apis mellifera) have served as targets for cellular senescence studies, but mitochondrial energy utilization with advancing age in workers is unknown. In this study, mitochondrial energy utilization was evaluated in the trophocytes and fat cells of young and old workers reared in a field hive. The results showed that (1) mitochondrial density increased with advancing age; (2) mitochondrial membrane potential (ΔΨm), nicotinamide adenine dinucleotide oxidized form (NAD + ) concentration, adenosine triphosphate (ATP) concentration, and NAD + /nicotinamide adenine dinucleotide reduced form (NADH) ratio decreased with advancing age; and (3) the expression of NADH dehydrogenase 1 (ND1), ATP synthase, and voltage-dependent anion channel 1 (VDAC1) increased with advancing age, whereas ND1 and ATP synthase did not differ with advancing age after normalization to mitochondrial density and VDAC1. These results show that the trophocytes and fat cells of young workers have higher mitochondrial energy utilization efficiency than those of old workers and that aging results in a decline in mitochondrial energy utilization in the trophocytes and fat cells of worker honeybees.

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Section: δψMsupporting

confidence: 92%

Changes in mitochondrial energy utilization in young and old worker honeybees (Apis mellifera)

Chuang

Hsu

2012

AGE

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“…ATP concentration decreases with age in the gastric mucosa and muscle of humans (Kawano et al 1991;Gurd et al 2008), the blood and brain of mice (Jayachandran et al 2005;Joo et al 1999), the erythrocytes of rabbits (Subasinghe and Spence 2008) and cows (Bartosz et al 1982), and the heart of rats (Guerrieri et al 1996). Similarly, we have found that ATP concentration decreases with age in the trophocytes and oenocytes of worker bees (Hsu and Chan 2013;Chuang and Hsu 2013).…”

Section: Nad + Nadh and Atp Concentrationssupporting

confidence: 66%

Mitochondrial energy utilization maintains young status in the trophocytes and oenocytes of old queen honeybees

Hsu

2015

Apidologie

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-The lifespans of queen honeybees (Apis mellifera ) are much longer than those of worker bees. Mitochondrial energy utilization in the trophocytes and oenocytes of worker bees during aging has been determined, but it remains unknown in queen bees. In this study, mitochondrial energy utilization was assayed in the trophocytes and oenocytes of young and old queen bees. The mitochondrial density and mitochondrial membrane potential (Δψm); nicotinamide adenine dinucleotide (NAD + ), nicotinamide adenine dinucleotide reduced form (NADH), and adenosine triphosphate (ATP) levels; NAD + /NADH ratio; and relative expression of NADH dehydrogenase 1 (ND1) and ATP synthase normalized against mitochondrial density were not significantly different between young and old queen bees. These results indicate that mitochondrial energy utilization maintains a young status in the trophocytes and oenocytes of old queen bees and that trophocytes and oenocytes have longevity-promoting mechanisms that can be investigated to clarify the secret of longevity in queen bees.

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“…Although age is a well-known cardiovascular risk factor (Vokonas et al 1988), studies examining the direct effects of aging on platelet functioning have yielded heterogeneous results (Vericel et al 1988;Jayachandran et al 2005). Knight et al (1997) found age was associated with decreased PSEL platelet activity, while the current study did not find any significant association between age and platelet responses to acute stress.…”

Section: Discussioncontrasting

confidence: 56%

Longitudinal platelet reactivity to acute psychological stress among older men and women

Aschbacher

Känel

Mills

et al. 2009

Stress

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Platelet reactivity to acute stress is associated with increased cardiovascular disease risk; however, little research exists to provide systematic methodological foundations needed to generate strong longitudinal research designs. Study objectives were: 1) to evaluate whether markers of platelet function increase in response to an acute psychological stress test among older adults, 2) to establish whether reactivity remains robust upon repeated administration (i.e. three occasions approximately 1 year apart), and 3) to evaluate whether two different acute speech stress tasks elicit similar platelet responses. The 149 subjects (mean age 71 years) gave a brief impromptu speech on one of two randomly assigned topics involving interpersonal conflict. Blood samples drawn at baseline and post-speech were assayed using flow cytometry for platelet responses on three outcomes (% aggregates, % P-selectin expression, and % fibrinogen receptor expression). Three-level hierarchical linear modeling analyses revealed significant stress-induced increases in platelet activation on all outcomes ( p , 0.001). No significant habituation on any measure was found. Additional reactivity differences were associated with male gender, history of myocardial infarction, and use of aspirin, statins, and antidepressants. The results demonstrate that laboratory acute stress tests continued to produce robust platelet reactivity on three activation markers among older adults over 3 years.

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Platelet Characteristics Change With Aging: Role of Estrogen Receptor

Cited by 35 publications

References 29 publications

Changes in mitochondrial energy utilization in young and old worker honeybees (Apis mellifera)

Changes in mitochondrial energy utilization in young and old worker honeybees (Apis mellifera)

Mitochondrial energy utilization maintains young status in the trophocytes and oenocytes of old queen honeybees

Longitudinal platelet reactivity to acute psychological stress among older men and women

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