Platelet count as an independent predictor differentiating between tuberculosis and non-tuberculosis pneumonia

Hui, K P; Chin, N K; Chan, Tiong Beng; Tan, Wan C.; Chow, K. M.; Brown, Alan; Kumarasinghe, Gamini

doi:10.1016/0962-8479(94)90048-5

Cited by 4 publications

(3 citation statements)

References 1 publication

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“…We propose that the predictive value of the platelet count for this diagnosis should be evaluated. Indeed, the haematological perturbations during PT include thrombocytosis as a component of an in¯ammatory anaemia process, and we report, in agreement with the ® ndings of Hui et al 40 , an association between thrombocytosis and PT in HIV-infected ( Figure 2) as is seen in HIVnegative patients (data not shown).…”

supporting

confidence: 93%

A proposal for basic management of HIV disease in West Africa: use of clinical staging and haemogram data

Ledru¹,

Diagbouga²,

Méda³

et al. 1998

Int J STD AIDS

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Our objective was to propose a strategy to screen HIV-infected African people for biological immunodeficiency easily. In a cross-sectional study, we analysed the patterns of diseases and of CD4 counts among 266 HIV-infected adults. Peripheral facial paralysis and chronic cutaneo-mucous diseases were the earlier B-stage diseases. Pulmonary tuberculosis was close to B-stage diseases, and chronic diarrhoea was borderline between B and C stages. Cachexia was the most frequent C-stage symptom (47.8%). Ninety per cent of CDC-C stage people had CD4 counts below 350/microliter, whereas only 75% had CD4 counts below 200/microliter. Regression analysis identified the lymphocyte count, clinical stage and platelet count as predictors of CD4 count below 350/microliter. A simple score (lymphocyte count < or = 2500/microliter and clinical stage > or = B) is proposed to determine this CD4 threshold (positive predictive value: 83%) and to determine those patients needing treatment to prevent wasting and opportunistic infections.

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supporting

confidence: 93%

A proposal for basic management of HIV disease in West Africa: use of clinical staging and haemogram data

Ledru¹,

Diagbouga²,

Méda³

et al. 1998

Int J STD AIDS

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“…38 Reactive thrombocytosis is a recognised response in adult pulmonary TB, 39 and has been proposed as an independent predictor to differentiate TB from non-TB pneumonia with values .400610 9 /L suggesting a diagnosis of TB. 40 Thrombocytosis is also considered a component of the APR and, in adults with pulmonary TB, a relationship has also been demonstrated between higher interleukin-6 concentrations and thrombocytosis. 41 In a large group of South African children, the mean (SD) platelet count in those with severe disseminated forms of TB was 552 (215610 9 /L), and this was significantly higher than in children with other forms of TB or children without TB.…”

Section: Discussionmentioning

confidence: 98%

Nutritional status and its response to treatment of children, with and without HIV infection, hospitalized for the management of tuberculosis

Schaaf

Cilliers

Willemse

et al. 2012

Paediatrics and International Child Health

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“…Furthermore, platelets activate the immune system of the lungs via numerous cytokines. In vivo studies have revealed that the platelet count ( 17 ) and platelet factor-4 level ( 12 ) are elevated in TB patients, especially in cases with extensive pulmonary infiltration. A decreased platelet count may indicate a decreased defense against co-morbid infection ( 18 ).…”

Section: Discussionmentioning

confidence: 99%

The Platelet Count Can Predict In-hospital Death in HIV-negative Smear-positive Pulmonary Tuberculosis Inpatients

et al. 2018

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Objective This retrospective cohort study investigated whether the three components of the blood cell count have prognostic implications in HIV-negative Japanese adult inpatients with smear-positive pulmonary tuberculosis. Methods We reviewed patients who were treated by the isoniazid, rifampicin, pyrazinamide, and ethambutol regimen or by the isoniazid, rifampicin, and ethambutol regimen. The association between the patient data on admission and the survival outcome was evaluated. Results We reviewed 367 consecutive patients (male, 60.5%) with a median age of 72 [interquartile range (IQR), 54-82] years. While the white blood cell count did not differ between the two groups, (discharged alive: 7,000/μL; IQR, 5,500-9,300; died in hospital: 7,200/μL; IQR, 5,600-9,400; p=0.797), hemoglobin level (discharged alive: 11.5 g/dL; IQR, 10.0-13.1; died in hospital: 9.9 g/dL; IQR, 8.6-11.3; p<0.001) and the platelet count (discharged alive: 275,000/μL; IQR, 206,000-345,000; died in hospital: 149,000/μL; IQR, 93,000-236,000; p<0.001) were lower in patients who died in hospital. After dividing patients into hemoglobin- and platelet-based quantiles, the lower quantile class tended to show poorer survival (log-rank test for trend p<0.001 for both). A multi-variable Cox proportional hazards model revealed that hazard ratio for in-hospital death for every 1,000/μL increase of platelet count was 0.997 (95%CI, 0.995-0.999; p=0.010); the hazard ratio for the hemoglobin level was not significant. Conclusion A low platelet count was clearly related to a poor life prognosis in HIV-negative Japanese adult inpatients with smear-positive pulmonary tuberculosis.

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Platelet count as an independent predictor differentiating between tuberculosis and non-tuberculosis pneumonia

Cited by 4 publications

References 1 publication

A proposal for basic management of HIV disease in West Africa: use of clinical staging and haemogram data

A proposal for basic management of HIV disease in West Africa: use of clinical staging and haemogram data

Nutritional status and its response to treatment of children, with and without HIV infection, hospitalized for the management of tuberculosis

The Platelet Count Can Predict In-hospital Death in HIV-negative Smear-positive Pulmonary Tuberculosis Inpatients

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