Platelet Damage induced in Plasma by Certain Fatty Acids

Shore, Parkhurst A.; Alpers, Hilma S.

doi:10.1038/2001331a0

Cited by 112 publications

(11 citation statements)

References 6 publications

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“…These findings support the hypothesis that a plasma factor, possibly related to changes in the saturated-unsaturated fatty acid ratio of lecithins and/or lysolecithins, may be responsible for the well-known changes in platelet behaviour (Shore and Alpers, 1963;Caspary, Prineas, Miller, and Field, 1965;Wright, Thompson, and Zilka, 1065; Thompson, 1966), and in the formation ofmicrothrombi (Putnam, 1935;Kerr, Pirrie, MacAulay, and Bronte-Stewart, 1965) in MS patients. The lipid changes should therefore be studied over a long period of time in the same subjects.…”

supporting

confidence: 81%

“…On the contrary, the concentration of plasma lysolecithins, but not lecithins, was significantly increased in MS patients and their fatty acid patterns changed in a significant way; more particularly, there was an increase of saturated fatty acids in lysolecithins. The increase in concentration ofthe lysolecithin fraction and its saturated fatty acids may explain the well-known changes in platelet behaviour in MS patients (Shore and Alpers, 1963;Caspary et al, 1965;Wright et al, 1965) and the correlation of multiple sclerosis epidemiology with diets and with other diseases such as atherosclerosis (McAlpine, Lumsden, and Acheson, 1965). Therefore, the observed modifications could be very important in the pathogenetic mechanisms of multiple sclerosis.…”

Section: Discussionmentioning

confidence: 98%

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Significance of plasma lysolecithin in patients with multiple sclerosis: a longitudinal study

Andreoli

Maffei

Tonon

et al. 1973

Journal of Neurology, Neurosurgery & Psychiatry

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SUMMARY Five patients with multiple sclerosis and four normal subjects have been followed for over two years. Plasma phospholipid levels and phospholipid fatty acid composition have been assayed periodically. The increased amount of plasma lysolecithin already described by us has been confirmed in this longitudinal study. A significant increase in saturated fatty acids of lysolecithin has also been demonstrated. In contrast, the lecithin concentration and fatty acid composition do not show any significant variations. The lysolecithin saturated/unsaturated fatty acid ratio was different in the same patients at different times, but no correlation was established between these variations and the clinical symptoms measured using the Kurtzke scale. The possible significance of saturated fatty acid increase in lysolecithin in the pathogenetic mechanisms of multiple sclerosis is discussed.

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supporting

confidence: 81%

Section: Discussionmentioning

confidence: 98%

Significance of plasma lysolecithin in patients with multiple sclerosis: a longitudinal study

Andreoli

Maffei

Tonon

et al. 1973

Journal of Neurology, Neurosurgery & Psychiatry

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“…

Following the pioneer work of C o n n o r and H o a k [2][3][4]10] on the aggre gating properties and the thrombogenicity of long-chain saturated fatty acids, extensive studies on the effect of these substances on platelet aggrega tion have been performed in recent years [5,9,13,16,19,21,22], Despite this, it seems that the mechanism of platelet aggregation by these fatty acids has not yet been elucidated. However, it has been suggested by H aslam [8] that the aggregation induced by fatty acids and thrombin was mediated by ADP since the aggregating effect of these agents could be inhibited by ade nosine.

The present work was undertaken to try to further elucidate the me chanisms involved in the fatty acid-induced platelet aggregation.

…”

mentioning

confidence: 99%

Clot-Promoting and Platelet-Aggregating Effects of Fatty Acids

Prost-Dvojakovic¹,

Samama²

1973

Pathophysiol Haemos Thromb

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“…Lipids serve important functions as membrane phospholipids constituents [Huwiler and feilschifter, 2009]. Analysis of SFAs/USFAs ratios between normal subjects and MS patients have showed statistically significant increase in MS patients and an increase of SFAs may explain the well-known changes in MS patients [ Shore and Alpers , 1963;Caspary et al,1965;Wright et al, 1965]. In combination, changes in cytokine production may provide prolonged changes in inflammatory responses relative to the rapidly reequilibrating levels of PUFA and their metabolites.…”

Section: Edss P For Paired-t Test *mentioning

confidence: 99%

Erythrocyte membrane fatty acids in multiple sclerosis patients and hot-nature dietary intervention with co-supplemented hemp-seed and evening-primrose oils

Rezapour-Firouzi¹,

Arefhosseini²,

Ebrahimi-Mamaghani³

et al. 2013

Afr. J. Trad. Compl. Alt. Med.

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The risk of developing multiple sclerosis (MS) is associated with increased dietary intake of saturated fatty acids. For many years it has been suspected that this disease might be associated with an imbalance between unsaturated and saturated fatty acids. We determined erythrocyte membrane fatty acids levels in Hot nature dietary intervention with co-supplemented hemp seed and evening primrose oils in multiple sclerosis patients. To determine the erythrocyte membrane fatty acids levels and correlate it with expanded disability status scale (EDSS) at baseline after 6 months intervention in MS patients by gas chromatography, in this double blind, randomized trial, 100 RRMS patients with EDSS<6 were allocated into three groups: "Group A" that received co-supplemented hemp seed and evening primrose oils with advised Hot nature diet. "Group B" received olive oil and "Group C" received the co-supplemented oils. The results showed that the mean follow-up was 180±2.9SD days (N=65, 23 M and 42 F aged 34.25±8.07 years with disease duration of 6.80±4.33 years). There was no significant difference in the study parameters at baseline. After 6 months, EDSS, Immunological parameters and the erythrocyte cell membrane with regard to specific fatty acids showed improvement in the group A and C, whereas there was worsening condition for the group B after the intervention. We concluded that Hot-nature dietary intervention with co-supplemented hemp seed and evening primrose oils caused an increase PUFAs in MS patients and improvement in the erythrocyte membrane fatty acids composition. This could be an indication of restored plasma stores, and a reflection of disease severity reduction.

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Platelet Damage induced in Plasma by Certain Fatty Acids

Cited by 112 publications

References 6 publications

Significance of plasma lysolecithin in patients with multiple sclerosis: a longitudinal study

Significance of plasma lysolecithin in patients with multiple sclerosis: a longitudinal study

Clot-Promoting and Platelet-Aggregating Effects of Fatty Acids

Erythrocyte membrane fatty acids in multiple sclerosis patients and hot-nature dietary intervention with co-supplemented hemp-seed and evening-primrose oils

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