Platelet Depletion after Thoraco-Abdominal Aortic Aneurysm Endovascular Repair is Associated with Clinically Relevant Hemorrhagic Complications

Pini, Rodolfo; Faggioli, Gianluca; Gallitto, Enrico; Mascoli, Chiara; Fenelli, Cecilia; Angherà, Cecilia; Logiacco, Antonino; Ancetti, Stefano; Gargiulo, Mauro

doi:10.1016/j.avsg.2021.08.036

Cited by 3 publications

(1 citation statement)

References 11 publications

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“…In our study, we showed that pre-operative platelet reactivity (measured by using ASPI, TRAP and ADP tests) was a predictor of bleeding complications (9). Nevertheless, platelet depletion (reduction >60%) following EVAR was associated with postoperative bleeding and increased mortality in one study (38). On the other hand, Inoue et al demonstrated that the platelet count of patients with malignant type-2-endoleaks on 7 th day following the operation was lower than that of patients with completed EVAR or with benign type-2-endoleaks (39).…”

Section: Changes In Platelet Function After Endovascular Aortic Aneur...mentioning

confidence: 62%

Platelet function changes in patients undergoing endovascular aortic aneurysm repair: Review of the literature

Burban

Idzik

Gelo

et al. 2022

Front. Cardiovasc. Med.

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Patients with abdominal aortic aneurysm (AAA) have a higher risk of cardiovascular (CV) events, which seems to be associated with disturbed platelet (PLT) function. Endovascular aneurysm repair (EVAR) is an emerging, less-invasive treatment alternative to surgical AAA repair. Both platelet function abnormalities in patients with AAA and the effect of EVAR on platelet function are poorly understood. In this review, we aim to fill the gap regarding the effect of EVAR on PLT function in AAA patients by discussing PLT function disturbances in patients with AAA, PLT function changes after EVAR, evidence from clinical studies regarding PLT function before and after EVAR, and antiplatelet or and antithrombotic treatment in patients undergoing EVAR. The goal of our review is to summarize the contemporary knowledge and initiate further studies to better understand PLT function changes in patients undergoing EVAR, optimize the pharmacotherapy before and after EVAR and further improve outcomes in this group of patients.

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Section: Changes In Platelet Function After Endovascular Aortic Aneur...mentioning

confidence: 62%

Platelet function changes in patients undergoing endovascular aortic aneurysm repair: Review of the literature

Burban

Idzik

Gelo

et al. 2022

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

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Thrombocytopenia after Thoraco-Abdominal Aortic Endografting: Pathophysiological Observations

Manenti¹,

Roncati²,

Farinetti³

et al. 2022

Annals of Vascular Surgery

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The Development of Totally Percutaneous Aortic Arch Repair With Inner-Branch Endografts: Experience From 2 Centers

et al. 2023

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Objective: The main objective of this study is to present the experience of 2 centers undertaking total percutaneous aortic arch-branched graft endovascular repair using combination of femoral and axillary routes. The report summarizes the procedural steps, outcomes achieved, and the benefits of this approach, which eliminates the need for direct open surgical exposure of the carotid, subclavian, or axillary arteries, thereby reducing the unnecessary associated surgical risks. Methods: Retrospectively collected data of 18 consecutive patients (15M:3F) undergoing aortic arch endovascular repair using a branched device between February 2021 and June 2022 at 2 aortic units. Six patients were treated for a residual aortic arch aneurysm following previous type A dissection with size range of (58–67 mm in diameter), 10 were treated for saccular or fusiform degenerative atheromatous aneurysm with size range of (51.5–80 mm in diameter), and 2 were treated for penetrating aortic ulcer (PAU) with size range of (50–55 mm). Technical success was defined as completion of the procedure and satisfactory placement of the bridging stent grafts (BSGs) in the supra-aortic vessels percutaneously including the brachiocephalic trunk (BCT), left common carotid artery (LCCA), and left subclavian artery (LSA) without the need for carotid, subclavian, or axillary cut down. The primary technical success was examined as primary outcome well as any other related complications and reinterventions as secondary outcomes. Results: The primary technical success with our alternative approach was achieved in all 18 cases. There was one access site complication (groin haematoma), which was managed conservatively. There was no incidence of death, stroke, or cases of paraplegia. No other immediate complications were noted. Postoperative imaging confirmed supra-aortic branch patency, with satisfactory position of the BSGs and immediate aneurysm exclusion except in 4 patients who had type 1C endoleak (Innominate: 2, LSA 2) detected on the first postoperative scan. Three of them were treated with relining/extension, and 1 spontaneously resolved after 6 weeks. Conclusions: Total percutaneous aortic arch repair with antegrade and retrograde inner-branch endografts can be performed with promising early results. Dedicated steerable sheaths and appropriate BSG would optimize the percutaneous approach for aortic arch endovascular repairs. Clinical Impact This article provides an alternative and innovative approach to improve the minimally invasive techniques in the endovascular treatment of the aortic arch conditions.

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Platelet Depletion after Thoraco-Abdominal Aortic Aneurysm Endovascular Repair is Associated with Clinically Relevant Hemorrhagic Complications

Cited by 3 publications

References 11 publications

Platelet function changes in patients undergoing endovascular aortic aneurysm repair: Review of the literature

Platelet function changes in patients undergoing endovascular aortic aneurysm repair: Review of the literature

Thrombocytopenia after Thoraco-Abdominal Aortic Endografting: Pathophysiological Observations

The Development of Totally Percutaneous Aortic Arch Repair With Inner-Branch Endografts: Experience From 2 Centers

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