Platelet-derived alpha-granules are associated with inflammation in patients with NK/T-cell lymphoma-associated hemophagocytic syndrome

Ren, Quanguang; Chan, Ka wo; Huang, He; Wang, Zhao; Fang, Xiaojie; Guo, Chengcheng; Li, Fangfang; Zhang, Limei; Yao, Yuyi; Chen, Zegeng; Tian, Ying; Lin, Tongyu

doi:10.1016/j.cyto.2019.154878

Cited by 13 publications

(6 citation statements)

References 36 publications

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“…Other causes for cytokine storms include autoinflammatory disorders, hemophagocytic lymphohistiocytosis, cancers, and monogenic disorders (6). Hematological malignancy, especially involving peripheral T cells or the NK-cell lineage, is the most common and has the worst prognosis for cytokine storm syndrome ( 15 – 17 ).…”

Section: Discussionmentioning

confidence: 99%

Progressive Heart Failure and Death as the Initial Manifestation of NK/T-Cell Lymphoma: A Case Report and Literature Review

Zhang

Wang

Liang

et al. 2021

Front. Cardiovasc. Med.

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Natural killer/T-cell (NK/T-cell) lymphoma is a rare-type non-Hodgkin lymphoma derived from NK cells or cytotoxic T cells. Here, we present a case of a 40-year-old woman who experienced quick-developed global heart failure and then was diagnosed with NK/T-cell lymphoma through lymphoid biopsy. Neither transthoracic echocardiography nor any radiological images detected a mass in her heart or pericardium. Elevated plasma troponin level and diffused patchy areas of gadolinium late enhancement on cardiac magnetic resonance were compatible with myocarditis. Considering the persistently elevated cytokine level, systemic inflammation symptoms, acute respiratory distress syndrome, and cardiac dysfunction, a cytokine storm secondary to NK/T-cell lymphoma was considered. Due to the refractory malignant arrhythmia, the patient died soon after being admitted to our hospital.

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Section: Discussionmentioning

confidence: 99%

Progressive Heart Failure and Death as the Initial Manifestation of NK/T-Cell Lymphoma: A Case Report and Literature Review

Zhang

Wang

Liang

et al. 2021

Front. Cardiovasc. Med.

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“…Due to diagnostic difficulties, works are in progress to identify new diagnostic markers for HLH. Ren et al performed studies using enzyme-linked immunosorbent assay (ELISA) on HLH patients with NK/T cell lymphoma [ 26 ]. They concluded that platelet factor 4 (PF4) and angiopoietin-4 (ANG-4) elevated in the serum and downregulated platelet-derived growth factors (PDGFs) may be useful biomarkers for early detection of NK/TLAHS.…”

Section: Discussionmentioning

confidence: 99%

Hemophagocytic Lymphohistiocytosis Secondary to Peripheral T Cell Lymphoma with Rapid Onset and Fatal Progression in a Young Patient: A Case Report and Review of the Literature

et al. 2021

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Patient: Male, 28-year-old Final Diagnosis: Hemophagocytic lymphohistiocytosis (HLH) Symptoms: Fever • neutropenia • thrombocytopenia Medication: — Clinical Procedure: — Specialty: Hematology Objective: Rare disease Background: Constant stimulation of lymphocytes and histiocytes can result in hemophagocytic lymphohistiocytosis (HLH), which can be primary or secondary (sHLH). The main causes of sHLH are infections and hematological malignancies, especially non-Hodgkin lymphoma. Despite new insights into the pathogenesis of HLH, the diagnosis and treatment of this immune disorder remain a great challenge. Case Report: We present a case of a young adult without comorbidities whose clinical course was nonspecific for several months and resulted in late diagnosis of HLH secondary to peripheral T cell lymphoma (PTCL). The etiological factor of recurring fever, hepatosplenomegaly, and deteriorating condition was unidentified for a long time before fatal sHLH was finally diagnosed. The patient was treated according to the HLH-2004 protocol; however, he did not achieve any response. Unfortunately, due to nonspecific symptoms, lack of lymphadenopathy for a long time, and negative positron emission tomography results, the diagnosis of PTCL was established only after the patient’s death. Conclusions: It should be emphasized that early diagnosis is crucial for better prognosis of patients with sHLH. Bone marrow biopsy is worth considering in patients with prolonged fever of unknown origin, hyperferritinemia, splenomegaly, and unexplained cytopenia of 2 or more lineages. Despite the existence of diagnostic and therapeutic protocols available in the literature, the prompt diagnosis and treatment of HLH remains a great challenge. More precise and specific diagnostic tools for HLH are needed.

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“…Proteins with fold-change values over 1.2 or less than 0.83 and P-values less than 0.05 were considered to be DEPs according to the published literatures. 19,20…”

Section: Methodsmentioning

confidence: 99%

Comparative secretome profile analysis of cultured immortalized human endometrial stromal cells supplemented with implanted versus nonimplanted blastocyst‐conditioned medium: A preliminary analysis

Xiong

Yao

Chen

et al. 2020

J of Obstet and Gynaecol

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Aim Human endometrial stromal cells (HESCs) were previously shown to be capable of discriminating embryos with different qualities. Here we aimed to compare the specific response of the HESC secretome to implanted blastocyst‐conditioned medium (BCM) versus nonimplanted medium and identify cytokine candidates useful for the assessment of blastocyst implantation. Methods Cleavage embryos were individually cultured in one microdrop of medium for blastocyst formation. The BCM was collected after fresh blastocyst transfer on day 5 and used to supplement HESC culture medium. A high‐throughput antibody array covering 440 cytokines was used to detect the secretory proteins of HESCs supplemented with implanted or nonimplanted BCM. Results A total of 22 differentially expressed proteins were found out of 440 cytokines in the supernatant of HESCs supplemented with BCM from the implanted group compared to the nonimplanted group, including seven upregulated and 15 downregulated proteins. Gene Ontology enrichment analysis showed that the differentially expressed proteins were mainly involved in cell chemotaxis and motility, and ERK1/2 cascade regulation. Kyoto Encyclopedia of Genes and Genomes analysis suggested that the mitogen‐activated protein kinase and phosphatidylinositol 3 kinase/Akt pathways were mainly involved. Conclusion HESCs specifically responded to BCM from different quality blastocysts, a finding that can be used to develop a novel approach for blastocyst quality assessment.

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Platelet-derived alpha-granules are associated with inflammation in patients with NK/T-cell lymphoma-associated hemophagocytic syndrome

Cited by 13 publications

References 36 publications

Progressive Heart Failure and Death as the Initial Manifestation of NK/T-Cell Lymphoma: A Case Report and Literature Review

Progressive Heart Failure and Death as the Initial Manifestation of NK/T-Cell Lymphoma: A Case Report and Literature Review

Hemophagocytic Lymphohistiocytosis Secondary to Peripheral T Cell Lymphoma with Rapid Onset and Fatal Progression in a Young Patient: A Case Report and Review of the Literature

Comparative secretome profile analysis of cultured immortalized human endometrial stromal cells supplemented with implanted versus nonimplanted blastocyst‐conditioned medium: A preliminary analysis

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