Platelet-derived growth factor AA-modified electrospun fibers promote tendon healing

Wang, Linyou; Yang, Tiejun; Ding, Li; Ye, Xiao; Wu, Liang

doi:10.1177/08853282221139274

Cited by 4 publications

(2 citation statements)

References 29 publications

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“…Kang et al suggested that the long-term local PDGF delivery by porous microspheres modified with heparin has a great potential to enhance tendon healing in a rat model of Achilles tendinitis by suppressing inflammation responses ( Kang et al, 2019 ). PDGF-AA-modified poly (lactide-co-glycolide) acid (PLGA) electrospun fibers (PLGA-PDGF-AA) effectively promoted tendon healing by stimulating collagen synthesis, deposition, and mechanical strength of tendon tissue ( Wang et al, 2022 ). The sustained delivery of PDGF-BB via an electrospun DegraPol tube to the wound site in a full-transection rabbit AT model accelerated tendon wound healing by causing a more uniform cell distribution, with higher proteoglycan content and less fibrotic tissue ( Meier Burgisser et al, 2020 ).…”

Section: Gfs In At Injurymentioning

confidence: 99%

Growth factors in the treatment of Achilles tendon injury

Lin,

Li,

et al. 2023

Front. Bioeng. Biotechnol.

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Section: Gfs In At Injurymentioning

confidence: 99%

Growth factors in the treatment of Achilles tendon injury

Lin,

Li,

et al. 2023

Front. Bioeng. Biotechnol.

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“…The results showed hrEGF causes an increase in healing tissue at the levels of neovascular, tendon cells, fibroblasts, collagen, and tissue macrophages, and higher levels of TNF-α, IL-6, IL8, and CXCR2 [ 52 ]. Wang et al [ 53 ] found that platelet-derived growth factor AA-modified electrospun fiber (PLGA-PDGF-AA) effectively promoted tendon healing, and in summary, PLGA-PDGF-AA promoted regeneration after tendon-bone injury. PLGA-PDGF-AA is a potential adjunct to the repair of surgical tendon injuries.…”

Section: Growth Factorsmentioning

confidence: 99%

A Review of the Role of Tendon Stem Cells in Tendon-Bone Regeneration

Chen

Jiang

et al. 2023

Med Sci Monit

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Tendon-bone injuries are a prevalent health concern associated with sports and other physically demanding activities. These injuries have a limited innate healing ability, often leading to the formation of scar tissue rather than the regeneration of healthy tendon tissue. This scar tissue results from excessive fibrosis during the early healing process and often leads to reduced tendon function and an increased risk of reinjury. Traditionally, surgical reconstruction has been the primary treatment for tendon-bone injuries. However, restoring the natural structure and mechanical properties of tendons after surgical reconstruction presents a considerable challenge. Recently, the potential of stem cell therapy has been explored as an alternative treatment approach. In particular, a new type of pluripotent stem cell known as tendon stem cells (TDSCs) has been identified within tendon tissue. These cells exhibit the potential for self-renewal and multidirectional differentiation, meaning they can differentiate into fibroblasts and chondrocytes. These differentiated cells can aid in the repair and regeneration of new tissues by producing collagen and other matrix molecules that provide structural support. TDSCs have become a focal point in research for treating tendon-bone injuries and related conditions. The potential use of these cells provides a basis for both basic research and clinical applications, particularly in understanding the tendon-bone healing process and identifying factors that affect the ability of TDSCs to promote this healing. This review article aims to analyze the role of TDSCs in tendon-bone healing, understanding their therapeutic potential and contributing to the development of effective treatment strategies for tendon-bone injuries.

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