Platelet-derived VWF-cleaving metalloprotease ADAMTS-13

Liu, L.; Choi, Hiuwan; Bernardo, Aubrey; Bergeron, Angela L.; Nolasco, Leticia; Ruan, Changgeng; Moake, Joel L.; Dong, Jing

doi:10.1111/j.1538-7836.2005.01561.x

Cited by 102 publications

(80 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These results indicate that hepatic stellate cells play an important role in the regulation of plasma ADAMTS13 activity, although other sources of ADAMTS13 were reported (14)(15)(16).…”

Section: Introductionmentioning

confidence: 63%

Prediction of Hepatocellular Carcinoma Development by Plasma ADAMTS13 in Chronic Hepatitis B and C

Ikeda

Tateishi

Enooku

et al. 2011

Cancer Epidemiology, Biomarkers &Amp; Prevention

View full text Add to dashboard Cite

Background: Chronic liver injury evokes a wound healing response, promoting fibrosis and finally hepatocellular carcinoma (HCC), in which hepatic stellate cells play an important role. Although a blood marker of hepatic stellate cells is not known, those cells importantly contribute to the regulation of plasma a disintegrin-like and metalloproteinase with thrombospondin type-1 motifs 13 (ADAMTS13) activity, a defect of which causes thrombotic thrombocytopenic purpura.Methods: Plasma ADAMTS13 was evaluated in chronic hepatitis B or C patients with or without HCC.Results: Plasma ADAMTS13 activity significantly correlated with serum aspartate aminotransferase and alanine aminotransferase, liver stiffness value, and aspartate aminotransferase-to-platelet ratio index, irrespective of the presence of HCC, suggesting that it may reflect hepatocellular damage and subsequent wound healing and fibrosis as a result of hepatic stellate cell action. During the three-year follow-up period for patients without HCC, it developed in 10 among 81 patients. Plasma ADAMTS13 activity was significantly higher in patients with HCC development than in those without and was a significant risk for HCC development by univariate and multivariate analyses. Furthermore, during the one-year follow-up period for patients with HCC treated with radiofrequency ablation, HCC recurred in 55 among 107 patients. Plasma ADAMTS13 activity or antigen level was significantly higher in patients with HCC recurrence than in those without and was retained as a significant risk for HCC recurrence by multivariate analysis.Conclusions: Higher plasma ADAMTS13 activity and antigen level was a risk of HCC development in chronic liver disease.Impact: Plasma ADAMTS13 as a potential marker of hepatic stellate cells may be useful in the prediction of hepatocarcinogenesis. Cancer Epidemiol Biomarkers Prev; 20(10); 2204-11. Ó2011 AACR.

show abstract

“…These results indicate that hepatic stellate cells play an important role in the regulation of plasma ADAMTS13 activity, although other sources of ADAMTS13 were reported (14)(15)(16).…”

Section: Introductionmentioning

confidence: 63%

Prediction of Hepatocellular Carcinoma Development by Plasma ADAMTS13 in Chronic Hepatitis B and C

Ikeda

Tateishi

Enooku

et al. 2011

Cancer Epidemiology, Biomarkers &Amp; Prevention

View full text Add to dashboard Cite

show abstract

“…It encodes a 4.7-kb transcript that is expressed primarily in the stellate cells of the liver and a 2.4-kb transcript detectable in multiple tissues including placenta, skeletal muscle, and certain tumor cell lines (4)(5)(6)(7)(8). Some investigators have reported that ADAMTS13 may also be expressed in platelets and cultured endothelial cells (9)(10)(11). However, this observation remains controversial, and in Northern blotting studies a 4.7-kb band is detectable only in the liver.…”

Section: Pathophysiology Of Ttp Vwf and Adamts13mentioning

confidence: 91%

ADAMTS13 and microvascular thrombosis

Tsai¹

2006

Expert Review of Cardiovascular Therapy

View full text Add to dashboard Cite

SummaryInteraction between platelet and von Willebrand factor (VWF), a circulating adhesive glycoprotein, is essential for hemostasis under the high shear environments of arterioles and capillaries. If unregulated, this interaction may lead to unwarranted platelet thrombosis ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 motif, number 13), a plasma zinc metalloprotease synthesized primarily in the stellate cells of the liver, cleaves shear stress activated VWF, thereby preventing the occurrence of VWF-platelet interaction in the circulation. A profound deficiency of ADAMTS13, due to genetic mutations or autoimmune inhibitors, results in intravascular VWFplatelet aggregation and widespread microvascular thrombosis characteristic of thrombotic thrombocytopenic purpura (TTP). Cloning of ADAMTS13 and structure-function analysis of the enzyme are leading to exciting advances in the diagnosis and therapy of this hitherto mysterious disease.

show abstract

“…In the liver, ADAMTS13 is expressed primarily in the vitamin A-enriched stellate cells [9;10]. ADAMTS13 may also be expressed in platelets and endothelial cells [11][12][13].…”

Section: Adamts13 -Structure and Functionmentioning

confidence: 99%

Thrombotic Thrombocytopenic Purpura: A Thrombotic Disorder Caused by ADAMTS13 Deficiency

Tsai

2007

Hematology/Oncology Clinics of North America

View full text Add to dashboard Cite

Platelet-derived VWF-cleaving metalloprotease ADAMTS-13

Cited by 102 publications

References 46 publications

Prediction of Hepatocellular Carcinoma Development by Plasma ADAMTS13 in Chronic Hepatitis B and C

Prediction of Hepatocellular Carcinoma Development by Plasma ADAMTS13 in Chronic Hepatitis B and C

ADAMTS13 and microvascular thrombosis

Thrombotic Thrombocytopenic Purpura: A Thrombotic Disorder Caused by ADAMTS13 Deficiency

Contact Info

Product

Resources

About