Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1): A Potential Prognostic Marker Involved in Leukocyte Infiltration of Renal Cell Carcinoma

Anastassiou, Gerasimos; Duensing, Stefan; Steinhoff, Gustav; Zorn, Ulrich; Grosse, Jens; Dallmann, Iris; Kirchner, Hartmut; Ganser, Arnold; Atzpodien, Jens

doi:10.1159/000227548

Cited by 21 publications

(15 citation statements)

References 10 publications

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“…A similar association was reported in patients with non-small-cell lung carcinoma 31 and in those with renal tumors. 32 These findings are not surprising. A number of recent studies have demonstrated that the inflammatory cell infiltrate significantly contributes to the angiogenic process in malignant disease.…”

Section: Discussionmentioning

confidence: 92%

Tumor angiogenesis in lymph node-negative rectal cancer: Correlation with clinicopathological parameters and prognosis

et al. 2002

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Background: Intratumoral microvessel density (MVD) could be used as a prognostic factor in colorectal cancer. We retrospectively analyzed the value of microvessel count in predicting the clinical outcome of stage I and II (Dukes A and B) rectal cancer patients.Methods: Eighty-four patients who had undergone curative resection of lymph node-negative rectal cancer were included. Tumor type and differentiation, the depth of local invasion, venous invasion, the character of the invasive margin, and the degree of lymphocytic infiltration were evaluated for each tumor specimen. Immunohistochemical staining for the CD31 endothelial antigen was performed to highlight the microvessels.Results: The median value of MVD was 45 microvessels. Low MVD (microvessels Յ45) was observed in 41 patients (48.8%), and high MVD (Ͼ45) was found in 43 (51.2%). The presence of conspicuous lymphocytic infiltration was significantly associated with increased vessel density. With uni-and multivariate survival analysis MVD did not show any prognostic significance. The character of the invasive margin was the only parameter with independent prognostic value.Conclusions: MVD does not seem to provide any additional prognostic information when compared with standard histopathological parameters in lymph node-negative rectal cancer. It is likely that the strong association between MVD and the presence of conspicuous lymphocytic infiltration may interfere with its predictive value.

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Section: Discussionmentioning

confidence: 92%

Tumor angiogenesis in lymph node-negative rectal cancer: Correlation with clinicopathological parameters and prognosis

et al. 2002

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“…As summarized in Table 1, higher MVD has been reported in many studies to be a favorable prognostic factor (eg, a higher blood vessel density in CCRCC is correlated with a better prognosis or longer patient survival). 4,[14][15][16][17][18][19][20][21][22] However, other studies have reported opposite results correlating higher MVD with poorer prognosis, [23][24][25][26][27][28] whereas others have been unable to find a significant prognostic role for MVD. [29][30][31][32][33] The controversy could result from many nonmechanistic factors, including sample size, sampling bias, the different blood vessel markers chosen for immunohistochemical (IHC) characterization, the quality of IHC staining, the methods of vasculature quantification, and the methods of interpretation.…”

Section: Differential Analysis Of Tumor Vasculaturementioning

confidence: 99%

Complexity of tumor vasculature in clear cell renal cell carcinoma

Qian

Huang

Wondergem

et al. 2009

Cancer

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Clear cell renal cell carcinoma (CCRCC) is a highly vascularized cancer resistant to conventional chemotherapy and radiotherapy. Antiangiogenic therapy has achieved some effectiveness against this unique malignancy. The complexity of the tumor vasculature in CCRCC has led to differences in correlating tumor microvessel density with patient prognosis. The authors' recent findings demonstrated that there were at least 2 major categories of tumor vessels in CCRCC-namely, undifferentiated and differentiated-correlating with patient prognosis in contrasting ways, with higher undifferentiated vessel density indicating poorer prognosis, and higher differentiated vessel density correlating with better prognosis. Furthermore, the presence of pericytes supporting the differentiated vessels varied in CCRCC. The distributions of pericyte coverage and differentiated vessels in CCRCC were uneven. The tumor margin had a higher pericyte coverage rate for differentiated vessels than did the inner tumor area. The uneven distributions of pericyte coverage and differentiated vessels in CCRCC prompted the authors to revisit the mechanism of tumor central necrosis, which was also known to be a prognostic indicator for CCRCC. The discrepancy of prognostic correlation between protein and messenger RNA levels of vascular endothelial growth factor in CCRCC was discussed. The complexity of the tumor vasculature in CCRCC also led the authors to begin to re-evaluate the therapeutic effects of antiangiogenic agents for each type of tumor vessel, which will in turn significantly broaden understanding of tumor angiogenesis and improve therapeutic effect. Clear cell renal cell carcinoma (CCRCC) is a highly vascularized malignancy. As evaluated by 2-phase multidetector computed tomography angiography, CCRCC is found to be able to develop an aberrant capsular vascular supply with outflow through an ovarian vein or testicular vein, 1 although positron emission tomography shows that blood perfusion of the tumor is reduced compared with normal kidney tissues. 2 Our expression profiling study also indicated that the expression level of vascular endothelial growth factor (VEGF; a potent proangiogenesis factor) in CCRCC is 5-fold higher than in other types of kidney

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“…With use of the mean value, 24 (400/o) cases were positive and 36 (60%) were negative for TPnuc reactivity. The percentage of tumor cells with TPcyt ranged from 0 to 90% (mean 12 %).…”

Section: Expression Of Thymidine Phosphorylasementioning

confidence: 99%

Thymidine Phosphorylase Expression in Gallbladder Adenocarcinomas

Giatromanolaki¹,

Sivridis²,

Simopoulos³

et al. 2002

Int J Surg Pathol

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The expression of thymidine phosphorylase (TP), a potent chemotactic factor for endothelial cells, was studied in 60 adenocarcinomas of the gallbladder, by use of immunohistochemical techniques. Results on patterns of TP expression were correlated with angiogenesis (anti-CD31), histopathological variables, and patient survival. TP was frequently expressed in tumor cells, stromal cells, tumor-associated macrophages, and lymphocytes of gallbladder adenocarcinomas. The expression was mixed nuclear/cytoplasmic. However, only nuclear TP (TPnuc) expression by tumor cells was correlated with increased angiogenic activity. High angiogenesis, assessed as microvessel density (MVD), was the most significant prognostic factor. The subgroup of patients with TPnuc and medium/high MVD had the worst prognosis as evaluated by the survival curves. Furthermore, CD31+ lymphocytes, frequently seen in carcinomas with high-fibroblastic TP reactivity, were connected with an improved survival. It is concluded that angiogenesis, as verified by multivariate analysis, is the most important prognostic factor in gallbladder carcinomas. In these tumors, high histologic grade and low CD31+ lymphocytic infiltration are also independent predictors of poor prognosis. TP is associated with an aggressive phenotype apparently because of its anglogenic activity. Therapeutic strategies targeting TP may be of value in patients overexpressing this enzyme.

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Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1): A Potential Prognostic Marker Involved in Leukocyte Infiltration of Renal Cell Carcinoma

Cited by 21 publications

References 10 publications

Tumor angiogenesis in lymph node-negative rectal cancer: Correlation with clinicopathological parameters and prognosis

Tumor angiogenesis in lymph node-negative rectal cancer: Correlation with clinicopathological parameters and prognosis

Complexity of tumor vasculature in clear cell renal cell carcinoma

Thymidine Phosphorylase Expression in Gallbladder Adenocarcinomas

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