Platelet glycoprotein IIb HPA-3 polymorphism and acute coronary syndromes

Lekakis, John; Bisti, Sofia; Tsougos, Elias; Papathanassiou, Athanasios; Dagres, Nikolaos; Ikonomidis, Ignatios; Soteriadou, Ekaterini; Tselepis, Alexandros D.; Goudevenos, John; Kremastinos, Dimitris Th.

doi:10.1016/j.ijcard.2007.04.039

Cited by 11 publications

(8 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…HPA-3b, and homozygous HPA-3b/3b were associated with CAD in Tunisians, in agreement with a recent study, which demonstrated that HPA-3b allele and HPA-3b/3b genotype were associated with extensive coronary thrombosis [ST segment elevation) [36]. Our findings are in apparent disagreement with an earlier German study which demonstrated that neither HPA-1 nor HPA-3 variants, individually or in combination, are associated with increased CAD or MI risk [23], and with a Korean study which suggested that HPA-3b/b was protective of CAD in young (\56 years of age) male patients [37].…”

Section: Discussionsupporting

confidence: 92%

Human platelet alloantigens HPA-1, HPA-2, and HPA-3 polymorphisms associated with extent of severe coronary artery disease

Abboud

Ghazouani

Ben-Hadj-Khalifa

et al. 2009

J Thromb Thrombolysis

View full text Add to dashboard Cite

The contribution of human platelet antigen (HPA)-1 (GPIIb/IIIa), HPA-2 (GPIb/IX), and HPA-3 (GPIIb/IIIa) polymorphisms to the risk of coronary artery disease (CAD) was investigated in 341 CAD patients and 316 matched control subjects. HPA genotyping was performed by PCR-SSP. Regression analysis was employed in assessing the contribution of these variants to CAD risk. The frequency of HPA-1b (P = .009) and HPA-3b (P = .004) alleles, and HPA-1a/1b (P = .045), HPA-1b/1b (P = .007), and HPA-3b/3b (P = .008) genotypes were higher in patients than control subjects. No significant association was demonstrated between the HPA variants and 1-, 2- and 3-vessel disease. HPA-1b/2a/3b (Pc = .021) and HPA-1b/2b/3a (Pc = .002) haplotypes were positively associated with CAD, thereby conferring a disease susceptibility nature to these haplotypes. Multivariate analysis confirmed the positive association of HPA-1b/2a/3b (aOR = 3.72; 95% CI = 1.49-9.28), and in addition identified HPA-1b/2a/3a (aOR = 2.49; 95% CI = 1.06-5.86) to be positively associated with CAD, after adjusting for a number of covariates. Our results demonstrate positive association of HPA variants and specific HPA-1/HPA-2/HPA-3 haplotypes with CAD in Tunisians.

show abstract

Section: Discussionsupporting

confidence: 92%

Human platelet alloantigens HPA-1, HPA-2, and HPA-3 polymorphisms associated with extent of severe coronary artery disease

Abboud

Ghazouani

Ben-Hadj-Khalifa

et al. 2009

J Thromb Thrombolysis

View full text Add to dashboard Cite

show abstract

“…Many investigations support the idea that polymorphic variants in genes involved in the endothelial function [26], inflammation [27], lipid metabolism [28], thrombosis [29], and fibrinolysis [30] are strongly associated with ACS. ACS and DM2 have different pathophysiologic mechanisms; however, they share a close relationship and both converge in a chronic inflammatory state involving endothelial dysfunction [31, 32].…”

Section: Introductionmentioning

confidence: 99%

The 14 bp Del/Ins HLA-G Polymorphism Is Related with High Blood Pressure in Acute Coronary Syndrome and Type 2 Diabetes Mellitus

García-González

Valle

Rivas

et al. 2014

BioMed Research International

View full text Add to dashboard Cite

Immunologic and inflammatory processes are involved in the pathogenesis of acute coronary syndrome (ACS) and type 2 diabetes mellitus (DM2). Human leukocyte antigen-G (HLA-G) is a negative regulator of the immune response. This study evaluates the 14 bp Del/Ins HLA-G polymorphism in ACS and DM2. Three hundred and seventy individuals from Western Mexico were recruited and categorized into three groups: ACS (86), DM2 without coronary complications (70), and healthy subjects (214). Genotyping of the 14 bp Del/Ins HLA-G polymorphism was performed by PCR and Native-PAGE. The most common risk factors were hypertension and overweight in ACS and DM2, respectively. The genetic distribution of the 14 bp Del/Ins HLA-G polymorphism showed no significant differences between groups (P ≥ 0.23). Nonetheless, the Ins/Ins genotype was associated with high blood pressure (HBP) in the DM2 group (ORc = 1.65, P = 0.02). The genetic recessive model showed similar findings (ORc = 3.03, P = 0.04). No association was found in ACS, with a P of 0.05; nevertheless, the prevalence of Ins/Ins carriers was quite similar to that found in the DM2-HBP group. The 14 bp Del/Ins HLA-G polymorphism was not a susceptibility factor for ACS or DM2; however, the Ins/Ins genotype might have contributed to the development of HBP in the studied groups.

show abstract

“…These data were interpreted from the standpoint of a less important role of HPA-3 polymorphism compared with HPA-1 polymorphism. In contrast, in a more recent study with 118 Caucasian CAD patients those carrying HPA-3b allele in homozygous state had nearly 6 times higher risk of ST elevation MI compared with those heterozygous for HPA-3b or homozygous for HPA-3a allele (after adjustment for age, sex and vascular risk factors) [70]. Finally, in a Korean study with 1,073 CAD patients subgroup analysis revealed association of HPA-3 polymorphism with MI among male patients below 56 years of age and a low frequency of MI among those young males carrying the HPA-3b/b genotype [71].…”

Section: Gpiib/iiia Polymorphismmentioning

confidence: 73%

“…Several large studies addressed the issue of the possible effect of HPA-3 or GPIIb polymorphism on platelet function and its association with atherosclerosis and acute coronary syndromes [69][70][71]. Again, there are discrepancies in the obtained results, which may suggest variability of the functioning of this polymorphism confounded by age, ethnicity, disease state and possibly drug treatment.…”

Section: Gpiib/iiia Polymorphismmentioning

confidence: 99%

Platelet Function and Antiplatelet Therapy in Cardiovascular Disease: Implications of Genetic Polymorphisms

Shanker

Gasparyan²,

Kitas³

et al. 2011

CVP

View full text Add to dashboard Cite

Platelets play a crucial role in thrombosis, inflammation, immunity and atherogenesis. Antiplatelet agents are widely used in patients with acute coronary syndrome and other cardiovascular disorders. Aspirin and clopidogrel are the most commonly prescribed antiplatelet agents, with a relatively safe profile and efficiency in a variety of clinical conditions. Numerous prospective studies have revealed variability of antiplatelet efficacy. The so called "antiplatelet resistance" prompted a search for mechanisms implicated in poor responsiveness to aspirin and clopidogrel therapy. In this regard, genetic polymorphisms in the platelet receptor genes attracted considerable interest. Specific genetic variants in platelet receptors such as the P2Y12, glycoprotein (GP) IIb/IIIa, GPIa/IIa, GPIb/IX/V and the cytochrome P450 (CYP) family of genes are associated with variable response to antiplatelet therapy and cardiovascular events. Genetic polymorphisms and haplotypes that comprehensively capture the genetic information encoded within the platelet receptor genes can, to some extent, predict response to the antiplatelet drug better than any single genotype. Genotyping for multiple receptor variants in patients on antiplatelet therapy, complemented by standardized quantification of platelet function, can provide useful information for future drug design studies and possibly for personalized antiplatelet therapy and prevention of thrombotic events. Additional information is, however, needed to evaluate the cost-effectiveness of complex genetic and platelet function testing.

show abstract

Platelet glycoprotein IIb HPA-3 polymorphism and acute coronary syndromes

Cited by 11 publications

References 19 publications

Human platelet alloantigens HPA-1, HPA-2, and HPA-3 polymorphisms associated with extent of severe coronary artery disease

Human platelet alloantigens HPA-1, HPA-2, and HPA-3 polymorphisms associated with extent of severe coronary artery disease

The 14 bp Del/Ins HLA-G Polymorphism Is Related with High Blood Pressure in Acute Coronary Syndrome and Type 2 Diabetes Mellitus

Platelet Function and Antiplatelet Therapy in Cardiovascular Disease: Implications of Genetic Polymorphisms

Contact Info

Product

Resources

About