1994
DOI: 10.1111/j.1365-2362.1994.tb02062.x
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Platelet glycoprotein IIb‐IIIa and size are increased in acute myocardial infarction

Abstract: Platelet aggregation, which plays an important role in acute myocardial infarction (AMI), is mediated by fibrinogen binding to the platelet membrane glycoprotein (GP)IIb-IIIa (CD41). This study measured the relative number of GPIIb-IIIa complexes on platelets from patients immediately following AMI (n = 14) compared with those from controls (n = 14). Flow cytometry was used to demonstrate that there were, on average, 20% more GPIIb-IIIa complexes on platelets after AMI compared with controls. Platelet size was… Show more

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Cited by 199 publications
(151 citation statements)
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“…Higher MPV values are seen in patients with myocardial infarction and unstable angina [9]. Larger platelets contain more dense granules, produce more thromboxane A2, and express more glycoprotein Ib and IIb/IIIa receptors [10]. However, there are no published studies on the eff ect of cocaine use on MPV.…”
Section: Introductionmentioning
confidence: 92%
See 1 more Smart Citation
“…Higher MPV values are seen in patients with myocardial infarction and unstable angina [9]. Larger platelets contain more dense granules, produce more thromboxane A2, and express more glycoprotein Ib and IIb/IIIa receptors [10]. However, there are no published studies on the eff ect of cocaine use on MPV.…”
Section: Introductionmentioning
confidence: 92%
“…Patients with unstable angina have also been reported to have increased MPV compared to patients with stable angina [12]. Cocaine causes acute increase in heart rate, systolic and diastolic blood pressure [13], vasoconstriction in coronary arteries [10], accelerated coronary atherosclerosis [15], and direct myocardial injury [16]. All of these can contribute to cocaine-associated chest pain and also may aff ect platelets directly or indirectly.…”
Section: Discussionmentioning
confidence: 99%
“…Large platelets express higher levels of prothrombotic substances, thromboxane A2, serotonin, b-thromboglobulin, and procoagulatory surface proteins, such as P-selectin and glycoprotein IIIa. [6,7] Increased MPV is associated with gestational diabetes mellitus, [8] congestive cardiac failure, [9] hypertension, [10] hypercholesterolemia, [11] and smoking. [12] Therefore, we excluded all patients having and of the above mentioned diseases to reduce the confounding effect in our statistical analysis.…”
Section: Discussionmentioning
confidence: 99%
“…Larger platelets are metabolically and enzymatically more active than smaller ones, containing more prothrombotic materials, with increased thromboxane A 2 and B 2 and glycoprotein IIb-IIIa receptor expression. 35,36 They show decreased inhibition of aggregation by prostacyclin and greater aggregability in response to ADP in vitro. 37 Larger platelets are denser and contain more α-granules which release thrombotic substances including platelet factor 4, 38 Pselectin 35 and platelet derived growth factor, 39 a chemotactic and mitogenic factor contributing to vascular neointimal proliferation.…”
Section: Possible Mechanisms Of Action Of Mean Platelet Volume In Carmentioning
confidence: 99%