Platelet indices in patients with colorectal cancer

Karagöz, Bülent; Sücüllü, İlker; Sayan, Özkan; Bilgi, Oğuz; Tuncel, Tolga; Filiz, Ali İlker; Yücel, Ertan; Ozgun, Alpaslan; Erikçi, Alev Akyol; Alacacıoğlu, Ahmet; Kandemir, Emin Gökhan

doi:10.2478/s11536-009-0077-7

Cited by 10 publications

(10 citation statements)

References 14 publications

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“…According to literature data, studies concerning colorectal cancer and MPV yield divergent results. A study conducted by Karagöz et al [82] showed a higher platelet count in colorectal cancer patients as compared to healthy subjects and lack of differences in MPV between the study group and control. Moreover, no changes were noted in MPV between patients with and without colorectal cancer metastases.…”

Section: Mpv In Carcinomamentioning

confidence: 99%

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Mean Platelet Volume (MPV): New Perspectives for an Old Marker in the Course and Prognosis of Inflammatory Conditions

Korniluk

Koper-Lenkiewicz

Kamińska

et al. 2019

Mediators of Inflammation

405

350

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Platelet size has been demonstrated to reflect platelet activity and seems to be a useful predictive and prognostic biomarker of cardiovascular events. It is associated with a variety of prothrombotic and proinflammatory diseases. The aim is a review of literature reports concerning changes in the mean platelet volume (MPV) and its possible role as a biomarker in inflammatory processes and neoplastic diseases. PubMed database was searched for sources using the following keywords: platelet activation, platelet count, mean platelet volume and: inflammation, cancer/tumor, cardiovascular diseases, myocardial infarction, diabetes, lupus disease, rheumatoid arthritis, tuberculosis, ulcerative colitis, renal disease, pulmonary disease, influencing factors, age, gender, genetic factors, oral contraceptives, smoking, lifestyle, methods, standardization, and hematological analyzer. Preference was given to the sources which were published within the past 20 years. Increased MPV was observed in cardiovascular diseases, cerebral stroke, respiratory diseases, chronic renal failure, intestine diseases, rheumatoid diseases, diabetes, and various cancers. Decreased MPV was noted in tuberculosis during disease exacerbation, ulcerative colitis, SLE in adult, and different neoplastic diseases. The study of MPV can provide important information on the course and prognosis in many inflammatory conditions. Therefore, from the clinical point of view, it would be interesting to establish an MPV cut-off value indicating the intensity of inflammatory process, presence of the disease, increased risk of disease development, increased risk of thrombotic complications, increased risk of death, and patient’s response on applied treatment. Nevertheless, this aspect of MPV evaluation allowing its use in clinical practice is limited and requires further studies.

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Section: Mpv In Carcinomamentioning

confidence: 99%

“…Moreover, no changes were noted in MPV between patients with and without colorectal cancer metastases. MPV was not found to correlate with cancer location and advancement [82]. On the other hand, research performed by Li et al [20] demonstrated a significantly higher MPV level in colorectal cancer patients than in healthy subjects.…”

Section: Mpv In Carcinomamentioning

confidence: 99%

Mean Platelet Volume (MPV): New Perspectives for an Old Marker in the Course and Prognosis of Inflammatory Conditions

Korniluk

Koper-Lenkiewicz

Kamińska

et al. 2019

Mediators of Inflammation

405

350

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“…Hasil penelitian berbeda dengan penelitian Toka B dkk dan Karagoz dkk di Turki bahwa tidak terdapat perbedaan jumlah trombosit pada pasien kanker kolorektal nonmetastasis dan metastasis. 17,18 Penelitian Josa di Eropa didapatkan peningkatan jumlah trombosit preoperatif merupakan marker yang signifikan untuk OS yang buruk. 9 Penelitian Zu di China tahun 2018 memperlihatkan jumlah trombosit meningkat pada kanker kolorektal dibanding adenoma/pasien sehat.…”

Section: Hasilunclassified

“…19 Namun, hasil penelitian ini berbeda dengan penelitian Karagoz dkk bahwa kadar PDW tidak berbeda pada kanker kolorektal nonmetastasis dan metastasis. 18 Begitu juga dengan penelitian Toka B, dkk di Turki yang melakukan penelitian tentang perubahan kadar PDW pada pasien kanker kolon yang mendapat kemoterapi, hasilnya yaitu tidak terdapat perbedaan kadar PDW pada pasien kanker kolorektal metastasis dan pasien kanker kolorektal nonmetastasis. 17 Pada penelitian Zhu di China didapatkan kadar PDW meningkat pada kanker kolorektal dibanding orang sehat, namun kadar PDW lebih rendah pada kanker kolorektal dibanding adenoma kolorektal.…”

Section: Hasilunclassified

Perbedaan Indeks Trombosit Antara Pasien Kanker Kolorektal Nonmetastasis Dan Metastasis Di RSMH Palembang

Syahriana

Mediarty

Bahar³

et al. 2021

JKK

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Kanker kolorektal masih menjadi permasalahan kesehatan di dunia. Hal ini karena progresivitas kanker berkaitan dengan prognosis dan angka kematian. Salah satu faktor yang berhubungan dengan progresivitas dan metastasis pada kanker kolorektal adalah indeks trombosit. Penelitian ini bertujuan untuk mengetahui perbedaan indeks trombosit antara pasien kanker kolorektal nonmetastasis dan metastasis. Penelitian ini adalah penelitian analitik komparatif dengan pendekatan case-control. Subyek penelitian adalah pasien kanker kolorektal di Poliklinik Hematologi dan Onkologi Medik Penyakit Dalam dan di bangsal rawat inap Penyakit Dalam RSMH Palembang mulai Januari -Juli 2020. Sampel berupa darah yang diambil dari vena mediana cubiti. Indeks trombosit (jumlah trombosit, MPV dan PDW) diperiksa menggunakan automated hematology analyzer di Laboratorium Patologi Klinik RSMH Palembang. Data dianalisis menggunakan uji T tidak berpasangan. Hasil penelitian menunjukkan kadar trombosit (484,1±185,1/µL) lebih tinggi pada kelompok kanker kolorektal dengan metastasis dibandingkan kelompok nonmetastasis (361,9±97,9/µL) dengan nilai p=0,013. Kadar MPV (8,9±0,7 fl) dan PDW (9,1±1,4%) lebih rendah pada kelompok kanker kolorektal dengan metastasis dibandingkan kelompok nonmetastasis (masing-masing 9,5±0,8 fl dan 10,6±2,2%) dengan nilai p=0,019 dan 0,01. Pada penelitian ini terdapat perbedaan bermakna indeks trombosit antara pasien kanker kolorektal metastasis dan kanker kolorektal nonmetastasis.

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“…Higher values of PDW indicate labile volumetric difference when compared with normal individuals. PDW has been associated with poor prognosis in many cancers including hepatocellular,[ 5 ] pancreatic,[ 6 7 ] malignant melanoma,[ 8 ] thyroid,[ 9 10 ] laryngeal[ 11 ] colorectal,[ 12 13 14 ] gastric,[ 15 ] non-small cell lung carcinoma[ 16 ] and endometrial carcinoma. [ 17 ] Studies of PDW association with GBC are scarce.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of platelet distribution width as novel biomarker in gall bladder cancer

Siddeek

Gupta

et al. 2020

J Carcinog

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INTRODUCTION: Gall bladder cancer (GBC) tends to present in advanced stages, therefore, early diagnosis of GBC is necessary. There is no ideal single tumor marker available presently for the diagnosis and prognosis of GBC. Platelet distribution width (PDW) is an early marker for activated platelets and has been used in a variety of tumors to assess prognosis. This study was designed to evaluate the utility of PDW in identifying GBC patients and its association with tumor markers, staging and resectability of GBC. MATERIALS AND METHODS: This cross sectional study was done on 100 patients of GBC and 100 age- and sex- matched healthy controls. PDW was evaluated and compared between GBC and healthy controls. Receiver-operating characteristics was plotted to determine optimal cut-off for identifying GBC patients and to determine sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of PDW. Correlation between serum tumor markers (carbohydrate antigen 19-9, carcinoembryonic antigen, and carbohydrate antigen 125) and PDW were evaluated. Association of PDW with hyperbilirubinemia, staging and resectability of GBC was also studied. RESULTS: A significantly higher PDW with a median of 18.1 was observed in GBC as compared to healthy controls with median value of 13. PDW was found to have a very high sensitivity (90%), specificity (95%), PPV (94%) and NPV (90%) in identifying GBC at cut-off of 16 with area under the curve (AUC) of 0.97. An increase of PDW was observed with increasing stage and unresectable GBC. However, it was not statistically significant. Significant positive correlation was observed between PDW and all three serum tumor markers and good positive correlation with r = 0.61 was observed with CA 19-9. CONCLUSION: PDW was associated with GBC and may be considered as a cost- effective marker in adjunct to other investigations for the diagnosis of GBC.

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Platelet indices in patients with colorectal cancer

Cited by 10 publications

References 14 publications

Mean Platelet Volume (MPV): New Perspectives for an Old Marker in the Course and Prognosis of Inflammatory Conditions

Mean Platelet Volume (MPV): New Perspectives for an Old Marker in the Course and Prognosis of Inflammatory Conditions

Perbedaan Indeks Trombosit Antara Pasien Kanker Kolorektal Nonmetastasis Dan Metastasis Di RSMH Palembang

Evaluation of platelet distribution width as novel biomarker in gall bladder cancer

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