Platelet indices in preterm premature rupture of membranes and their relation with adverse neonatal outcomes

Abstract

Aim: Preterm premature rupture of membranes (PPROM) is not only the most common distinguishable cause of preterm delivery, but is also associated with adverse neonatal outcomes. We determined the platelet indices in PPROM cases and evaluated their relationship to adverse neonatal outcomes. Methods: Fifty patients with PPROM and 50 patients who experienced spontaneous preterm labor at < 37 gestational weeks were evaluated. Complete blood counts, birth weights, Apgar scores, presence of sepsis and respiratory distress syndrome (RDS) and neonatal intensive care unit admission were recorded. Results: Patients with PPROM had increased mean platelet volumes (9.40 vs 10; P = 0.01), plateletcrit (0.19 vs 0.21; P = 0.03) and a higher frequency of neonatal sepsis (18% vs 38%; P = 0.02). Platelet indices in the patient group were compared according to the development of RDS. Plateletcrit values were higher in the RDS positive group (0.23 AE 0.05 vs. 0.21 AE 0.04; P = 0.04). The cut-off value for plateletcrit was determined as > 0.22, and the probability of RDS increased 5.86 times when plateletcrit values exceeded 0.22 (odds ratio 5.86, 95% confidence interval 1.01-32.01; P = 0.04). A one-unit increase in platelet distribution width resulted in a 1.33-fold increase in the risk of RDS (odds ratio 1.33, 95% confidence interval 1.01-1.77; P = 0.04). Conclusion: Mean platelet volumes and plateletcrit significantly increased and plateletcrit had a predictive value for RDS in PPROM cases. Monitoring plateletcrit may be promising for predicting the development of RDS, one of the most common and serious complications of PPROM rupture.

Maternal Serum C-Reactive Protein and Mean Platelet Volume as Predictors of Preterm Premature Rupture of Membranes

“…The effectiveness of using platelet indices to predict preterm labor has also been studied. Gioia [15]. The results of our study are in line with Dundar et al We found that platelet count and MPV before the second trimester were significantly higher in women who went on to experience PPROM than in those who did not.…”

“…Mean platelet volume (MPV) can be used reliably to gauge platelet size, which indicates their function and activation. An association between both prothrombosis and proinflammation has been found [14], but research on the early predictive value of MPV and platelet count for PPROM is insufficient [9,15]. With this gap in the literature and given the established link between subclinical intrauterine infection and PPROM mechanisms, there is a need to examine the role of MPV and platelet count in PPROM.…”

Value of Neutrophil Lymphocytic Ratio and Platelet Lymphocytic Ratio in Premature Rupture of Membranes for Detection of Subclinical Chorioamnoitis

“…In contrary Dundar B, et al [14] showed that mean Neutrophil count in patients was 8. The only difference is the significance of CRP found in that study which because they did not exclude the cases with clinical chorioamnoitis, and of course all the biomarkers increase in clinical chorioamnoitis.…”

Maternal and cord blood parameters are associated with placental and newborn outcomes in indigenous mothers: A case study in the MINDI cohort

“…These observations are in agreement with our finding of higher cord hematocrit associated with lower birthweights and head circumference, but contrast with the negative association of cord platelet counts with head circumference. There is evidence that an increased production and activation of platelets during pregnancy occur during inflammatory processes leading to platelet consumption and to a hypercoagulable state that impacts placental micro-circulation and placental insufficiency 70 . Also, we had previously shown that higher plateletcrit was associated with higher C-reactive protein in pregnant and lactating Ngäbe women 24 .…”

“…Estas observaciones están de acuerdo con nuestros hallazgos de un hematocrito en sangre de cordón más alto asociado con menor peso al nacer y circunferencia cefálica, pero contrasta con la asociación de mayor conteo de plaquetas en sangre de cordón y menor circunferencia cefálica. Existe evidencia de que durante procesos inflamatorios en el embarazo se desarrolla un aumento en la producción y activación plaquetarias, llevando a un consumo de plaquetas y a un estado pro-coagulante que impacta en la microcirculación placentaria produciendo insuficiencia 70 . También, hemos mostrado previamente que un plaquetocrito mayor se asoció con una PCR más alta en mujeres embarazadas y lactantes Ngäbe 24 .…”