Platelet indices in type 2 diabetes mellitus and their association with microvascular complications

Kshirsagar, Ravindra M.; Deoke, Shilpa; Akhtar, Shamim

doi:10.18231/j.pjms.2019.007

Cited by 8 publications

(15 citation statements)

References 20 publications

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“…This goes with Kshirsagar et al [19] who reported decreased platelet count in diabetic compared to nondiabetic patients but was not statistically significant (P = 0.08), as well as with Buch et al [5] and Hekimsoy et al [12].…”

Section: Discussionsupporting

confidence: 74%

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Correlation between adiponectin level and the degree of fibrosis in patients with non-alcoholic fatty liver disease

Mohamed

Youssef

Abdullah

et al. 2021

Egypt Liver Journal

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Background Non-alcoholic fatty liver disease (NAFLD) is one of the most prevalent chronic liver diseases, particularly in Egypt. It is defined as the accumulation of lipids inside the hepatocytes, in the absence of other etiologies of hepatic damage. It is frequently associated with obesity, diabetes mellitus, and metabolic syndrome. Adiponectin is an abundant adipocyte-derived protein with well-established anti-atherogenic, insulin-sensitizing, and anti-inflammatory properties. The liver is a major target organ for adiponectin especially in fatty liver diseases, and this adipocytokine has the ability to control many liver functions including metabolism, inflammation, and fibrosis. In this study, we aimed to find out the correlation between the degree of liver fibrosis in NAFLD patients and their serum adiponectin level as a future non-invasive method for the assessment of liver fibrosis to substitute liver biopsy to avoid its hazardous complication and also to study the correlation between diabetes mellitus as well as obesity and serum adiponectin level. Results Fifty patients were selected to participate in our study based on our inclusion criteria. They were recruited from the Internal Medicine Department, Gastroenterology Clinic in Al-Demerdash Hospital using a convenient sampling method. Diagnosis of NAFLD was confirmed by laboratory markers: aspartate aminotransferase (AST), alanine aminotransferase (ALT), lipid profile, ultrasound, and FibroScan examination. Analyzing the adiponectin levels showed that besides its significant correlation with body mass index (BMI), hypertension, diabetes mellitus, and dyslipidemia, it was significantly lower in the high-grade fibrosis group compared to the low-grade fibrosis group with a P-value of (0.000) and a cutoff value for stage 3/4 fibrosis of about 2.31 μg/ml which marked a promising hope of adiponectin being of protective value against liver fibrosis. Conclusion Both serum levels and hepatic adiponectin receptor expression are decreased in NAFLD. Therefore, either adiponectin itself or adiponectin-inducing agents might be of key therapeutic interest in the near future in the treatment of NAFLD.

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Section: Discussionsupporting

confidence: 74%

“…Another noted highly significant correlation was found between lower platelet count and diabetes with a P-value of about 0.000. This may be because of various factors such as high production and turnover rate in T2DM with diminished mean platelet survival [19].…”

Section: Discussionmentioning

confidence: 99%

Correlation between adiponectin level and the degree of fibrosis in patients with non-alcoholic fatty liver disease

Mohamed

Youssef

Abdullah

et al. 2021

Egypt Liver Journal

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“…Evidence suggests that platelets from patients with T2DM have increased reactivity and baseline activation compared to healthy controls [ 49 ]. The function of platelet and its size are said to be related and large circulating platelets are reflected by higher MPV which is the marker of the average size, and platelet activity [ 50 ]. Diabetic platelets are larger with denser granules and they are enzymatically and functionally hyperactive to produce more prothrombotic factors like thromboxane A2, platelet factor 4, serotonin, and P-selectin than smaller platelets and hence cause an increased tendency to thrombotic events [ 51 ].…”

Section: Discussionmentioning

confidence: 99%

Hematological parameters of type 2 diabetic adult patients at Debre Berhan Referral Hospital, Northeast Ethiopia: A comparative cross-sectional study

et al. 2021

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Background Diabetes is a global public health problem and associated with metabolic, cellular, and blood disturbances. Hematological changes have been reported in diabetes and play a major role in diabetes-associated complications. However, reports are contradicting and data on hematological parameters of type 2 diabetic patients in the study area are scarce. Therefore, the aim of this study was to assess the hematological parameters of type 2 diabetic adult patients at Debre Berhan Referral Hospital, Northeast Ethiopia from May 01 to June 30, 2020. Methods A comparative cross-sectional study was conducted on 268 (134 type 2 diabetic patients and 134 controls) study participants selected by systematic random sampling technique. Socio-demographic, behavioral, and clinical data were collected using a structured questionnaire and checklist. Ethical approval was obtained from Jimma University. All phase of quality assurance was maintained. Hematological parameters and blood glucose levels were determined using UniCel DxH 800 (Beckman Coulter, USA) and Biosystems A25 (Costa Brava, Spain) analyzers, respectively. Independent t-test, Mann–Whitney U-test, correlation, and logistic regression were used during data analysis. P-value <0.05 was considered as statistically significant. Results The current study found that total white blood cell count, absolute counts of neutrophil, lymphocyte, eosinophil, and basophil, red blood cell distribution width, platelet count, and mean platelet volume were significantly higher in type 2 diabetic patients as compared to the control group (P<0.05). On the other hand, the mean hemoglobin was significantly lower in type 2 diabetic patients than the control group (P = 0.007). Anemia was found in 17.9% of type 2 diabetic patients. Longer duration of diabetes (AOR = 3.05, 95% CI = 1.12–8.34) and milk consumption (AOR = 4.60, 95% CI = 1.50–14.00) were significantly associated with anemia. Conclusion This study showed a statistically significant variation in some hematological parameters of type 2 diabetic patients compared to control group. Anemia among type 2 diabetic patients was found to be a mild public health problem. Therefore, routine screening of hematological parameters should be considered for proper management of type 2 diabetic patients. Close attention should also be given to the duration of diabetes and dietary practice.

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“…MPV and PDW can be the predictive biomarkers of diabetic microvascular complications. A study conducted by Kshirsagar et al [13] has demonstrated that MPV was significantly higher in diabetics than non-diabetic controls (p < 0.05). HbA1c (p < 0.05) and duration of diabetes (p < 0.05) were statistically significantly higher in diabetics with microvascular complications as compared with diabetics without microvascular complications.…”

Section: Discussionmentioning

confidence: 91%

Evaluation of platelet volume indices as predictive biomarkers of microvascular complications in patients with type 2 diabetes

Chawla¹,

Sahu²,

Punyani³

et al. 2020

Int J Diabetes Dev Ctries

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Introduction Patients with type 2 diabetes are known to have a higher risk of developing micro-and macrovascular complications which enhance the risk of morbidity and mortality. Increased platelet activity is postulated to be a vital mechanism in the development of vascular complications. Platelet volume indices (PVI), including mean platelet volume (MPV), platelet distribution width (PDW), and plateletcrit (PCT) are indicators of enhanced platelet activity and these may be useful markers of complications. Materials and methods We conducted a case-control study across 130 T2DM patients that were matched for age and gender with 130 people who did not have T2DM. Detailed demographic profile and clinical history including duration of diabetes along with complete physical examination was conducted. Fundus examination was conducted for direct ophthalmoscopy for retinopathy and Neuropathy Disability Score (NDS) was calculated to assess the severity of neuropathy. The biochemical investigations included were the platelet indices, fasting blood glucose (FPG), postprandial blood glucose, HbA1c, serum creatinine, and urine albumin.Results We observed that platelet indices, such as MPV, PDW, and PCT were significantly higher in diabetic individuals than in matched controls. Higher MPV, PDW, and PCT were observed in diabetic patients with microvascular complications compared with those without microvascular complications. We observed that patients with neuropathy with NDS > 6 had higher value of MPV, PDW, and PCT than compared with those with NDS < 6. There was significant difference for MPV between diabetics with and without complications and non-diabetics (p < 0.05). PDW and MPV were positively correlated with duration of diabetes. Conclusions The association between MPV, PDW, and PCT and diabetic retinopathy revealed that platelet indices were significantly higher than control group in both NPDR and PDR. However, we did not observe any difference in platelet indices in NPDR and patients without diabetic retinopathy. MPV, PDW, and PCT were higher in individuals with higher HbA1clevel and the correlation was found to be statistically significant.

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Platelet indices in type 2 diabetes mellitus and their association with microvascular complications

Cited by 8 publications

References 20 publications

Correlation between adiponectin level and the degree of fibrosis in patients with non-alcoholic fatty liver disease

Correlation between adiponectin level and the degree of fibrosis in patients with non-alcoholic fatty liver disease

Hematological parameters of type 2 diabetic adult patients at Debre Berhan Referral Hospital, Northeast Ethiopia: A comparative cross-sectional study

Evaluation of platelet volume indices as predictive biomarkers of microvascular complications in patients with type 2 diabetes

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