Platelet indices (mean platelet volume and platelet distribution width) have correlations with periodontal inflamed surface area in coronary artery disease patients: A pilot study

Temelli, Başak; Ay, Zühal Yetkin; Aksoy, Fatih; Büyükbayram, Halil İbrahim; Doğuç, Duygu Kumbul; Uşkun, Ersin; Varol, Ercan

doi:10.1002/jper.17-0684

Cited by 22 publications

(30 citation statements)

References 47 publications

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“…In our study, PISA values were consistent with the current classification for periodontal diseases 22 (as well as with the former CDC-AAP classification), 24 , 25 and increased with periodontal disease presence and increased severity. When compared to the other studies, 4 - 6 the higher PISA values reported in our study may be explained by the periodontitis generalized involvement of our groups. Another important finding suggests that gingivitis can cause as much systemic inflammatory burden as stage I periodontitis: the overlap in PISA values and the positive strong correlations between PISA and pro- and anti-inflammatory biomarker levels in gingivitis and stage I periodontitis groups.…”

Section: Discussioncontrasting

confidence: 66%

“…When compared to the other studies, [4][5][6] To the best of our knowledge, this is the first study to investigate serum and salivary NGAL levels considering different periodontal diseases and severity. We found all periodontal parameters and PISA values to proportionally increase with increased disease severity and NGAL levels.…”

Section: Groupsmentioning

confidence: 94%

“…3 Various studies used the PISA to understand the association between systemic diseases and periodontitis. [4][5][6] Considering their results, PISA may be used as a continuous periodontal variable in conjunction with microbiological or biochemical variables (cytokine(s)/mediator(s)) in periodontal medicine studies, to clarify any potential role in the pathogenesis of both periodontal and systemic diseases.…”

Section: Introductionmentioning

confidence: 99%

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Increase in serum and salivary neutrophil gelatinase-associated lipocalin levels with increased periodontal inflammation

et al. 2020

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Increase in serum and salivary neutrophil gelatinase-associated lipocalin levels with increased periodontal inflammation Objective: This study aimed to determine serum and salivary levels of neutrophil gelatinase-associated lipocalin (NGAL) and evaluate NGAL correlation with key anti-interleukin 10 (IL-10) and pro-inflammatory (IL-1β) cytokines in different severities of periodontal diseases. We also calculated the systemic inflammation using the periodontal inflamed surface area (PISA) to evaluate its correlation with NGAL in the study groups. Methodology: Eighty systemically healthy and non-smoking individuals were separated into four groups of 20: clinically healthy (Group 1), gingivitis (Group 2), stage I generalized periodontitis (Group 3, Grade A), and stage III generalized periodontitis (Group 4, Grade A). Sociodemographic characteristics and periodontal parameters were recorded, and PISA was calculated. The serum and salivary levels of interleukin (IL)-1β, IL-10, and NGAL were determined using the enzyme-linked immunosorbent assay (ELISA). Results: We observed a significant increase in serum and salivary NGAL levels from healthy to periodontitis groups (p=0.000). Group 2 presented significantly higher serum and salivary IL-10 levels and salivary IL-1β levels than Group 3 (p=0.000). Serum and salivary parameters (IL-1β, IL-10, and NGAL levels) were strongly positively correlated to periodontal parameters and PISA values (p=0.000). Groups 2 and 3 showed overlapping PISA values. Conclusion: The overlapping PISA values found in Groups 2 and 3 suggest that gingivitis might progress to a systemic inflammatory burden somewhat comparable to stage I periodontitis. This finding is supported by the higher serum and salivary cytokines/mediators levels in the gingivitis group than in stage I periodontitis group. Serum and salivary NGAL levels increased proportionally to disease severity and PISA. NGAL seems to play a role in the pathogenesis of periodontal disease, within the limitation of our study.

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Section: Discussioncontrasting

confidence: 66%

Section: Groupsmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

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Increase in serum and salivary neutrophil gelatinase-associated lipocalin levels with increased periodontal inflammation

et al. 2020

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“…Furthermore, PDW has also been regarded as a more concrete parameter for platelet activation than MPV, as it does not increase during simple platelet swelling [34, 35]. Accordingly, some studies have suggested a potential relationship between PDW and CAD [36, 37]. Our study showed that PDW was an independent risk factor for plaque rupture as well as TCFA occurrence in NSTE-ACS patients.…”

Section: Discussionsupporting

confidence: 50%

Mean platelet volume and coronary plaque vulnerability: an optical coherence tomography study in patients with non-ST-elevation acute coronary syndrome

Wang

et al. 2019

BMC Cardiovasc Disord

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Background The association between mean platelet volume (MPV) and coronary plaque vulnerability in patients with non-ST-elevation ACS (NSTE-ACS) has not been investigated. We performed a retrospective study to evaluate the association between MPV and plaque vulnerability using optical coherence tomography (OCT). Methods Consecutive NSTE-ACS patients who underwent pre-intervention OCT examination in our center were included in this study. Features of coronary plaques in the culprit arteries were classified as rupture, nonrupture with thin-cap fibroatheroma (TCFA), and nonrupture and non-TCFA. ROC analyses were used to determine the predictive efficacy of MPV for plaque rupture, and multivariate logistic regression analysis was performed to evaluate the potential independent predictors of plaque vulnerability. Results Overall, 94 patients were included in this study. We identified 17 patients with plaque rupture, 10 with nonrupture with TCFA, and 67 with nonrupture and non-TCFA. ROC analyses showed that MPV ≥ 10.5 fL was predictive of plaque rupture in NSTE-ACS patients. Univariate analyses indicated that patients with higher MPV (≥ 10.5 fL) had higher body mass index and poorer lipid profiles compared to those with lower MPV. Moreover, those with higher MPV had higher incidences of plaque rupture and thrombosis (both P < 0.05). Results of multivariate analyses showed that diabetes and higher platelet distribution width (PDW) were independent risk factors of TCFA ( P = 0.032 and 0.046, respectively), while diabetes, higher BMI, higher PDW, and higher MPV were independent determinants of plaque rupture in our cohorts (P all < 0.05). Conclusions Higher MPV is independently associated with higher risk of plaque rupture as evidenced by OCT in our cohort of NSTE-ACS patients.

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“…The link between periodontitis and leukocytosis is well documented [35][36][37][38][39][40]. This result is expected given the infectious nature of periodontitis where bacteria invade the periodontal tissues via the ulcerated epithelium, and leukocytes, in particular neutrophils, are triggered towards the periodontal injury [40][41][42].…”

Section: Discussionmentioning

confidence: 92%

Relationship between Blood and Standard Biochemistry Levels with Periodontitis in Parkinson’s Disease Patients: Data from the NHANES 2011–2012

Botelho

Lyra

Proença

et al. 2020

JPM

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People with Parkinson’s Disease (PD) are associated with the presence of periodontitis. We aimed to compare blood and standard biochemical surrogates of PD patients diagnosed with periodontitis with PD individuals without periodontitis. This retrospective cohort study used a sample from the National Health and Nutrition Examination Survey (NHANES) 2011–2012 that underwent periodontal diagnosis (n = 3669). PD participants were identified through specific PD reported medications. Periodontitis was defined according to the 2012 case definition, using periodontal examination data provided. Then, we compared blood levels and standard chemical laboratory profiles of PD patients according to the presence of periodontitis. Multivariable regression was used to explore this dataset and identify relevant variables towards the presence of periodontitis. According to the medication report, 37 participants were eligible, 29 were secure and 8 were unsecure PD medications regimens. Overall, PD cases with periodontitis presented increased levels of White Blood Cells (WBC) (p = 0.002), Basophils (p = 0.045) and Segmented neutrophils (p = 0.009), and also, lower levels of Total Bilirubin (p = 0.018). In the PD secure medication group, a significant difference was found for WBC (p = 0.002) and Segmented neutrophils (p = 0.002) for the periodontitis group. Further, WBC might be a discriminating factor towards periodontitis in the global sample. In the secure PD medication, we found gender, segmented neutrophils and Vitamin D2 to be potential discriminative variables towards periodontitis. Thus, periodontitis showed association with leukocyte levels alterations in PD patients, and therefore with potential systemic changes and predictive value. Furthermore, Vitamin D2 and gender showed to be associated with periodontitis in with secure medication for PD. Future studies should assess in more detail the potential systemic repercussion of the presence of periodontitis in PD patients.

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Platelet indices (mean platelet volume and platelet distribution width) have correlations with periodontal inflamed surface area in coronary artery disease patients: A pilot study

Abstract: The results of the present study highlight some blood parameters (PDW, RDW, and MPV) in CAD patients with/without periodontitis in terms of the relationship between inflammatory diseases and their significant low and moderate correlations with PISA values.

Cited by 22 publications

References 47 publications

Increase in serum and salivary neutrophil gelatinase-associated lipocalin levels with increased periodontal inflammation

Increase in serum and salivary neutrophil gelatinase-associated lipocalin levels with increased periodontal inflammation

Mean platelet volume and coronary plaque vulnerability: an optical coherence tomography study in patients with non-ST-elevation acute coronary syndrome

Relationship between Blood and Standard Biochemistry Levels with Periodontitis in Parkinson’s Disease Patients: Data from the NHANES 2011–2012

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