Platelet/leukocyte ratio as a predictor of mortality in patients with sepsis

Menezes, Bárbara Magalhães; Amorim, Fábio Ferreira; Santana, Adriell Ramalho; Soares, Felipe Bozi; Araújo, Fernanda Vilas Bôas; Carvalho, Jacqueline Rodrigues de; Araújo, Mariana Pinheiro Barbosa de; Santos, Louise Cristhine de Carvalho; Rocha, Pedro Henrique Gomes; Souza, Jaqueline Lima de; Gomes, Mateus Gonçalves; Júnior, Pedro Nery Ferreira; Amorim, Alethea Patrícia Pontes; Biondi, Rodrigo Santos; Ribeiro, Rubens Antônio Bento

doi:10.1186/cc12952

Cited by 2 publications

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“…Biomarkers, especially a combination of the two components, can provide more reliable guidance for predicting the outcome; mortality in sepsis. Recent studies, 3,4 also stated that combination biomarkers performed better than other clinical scores used routinely in predicting sepsis related mortality.…”

Section: Resultsmentioning

confidence: 99%

Albumin, Leukosit, And Protrombin As Predictors Of Sepsis Mortality Among Adult Patients In Soetomo General Hospital, Surabaya, Indonesia

Zharfan

Hakim

Purba

et al. 2019

IJAR

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Introduction: Sepsis is presented as acomplex and multifactorial syndrome where the morbidity and mortality rates still high around the world. Strong evidencewith regard to early predictive factors for mortality and morbidity is rare to be provided. Objective: The aim of this study was to analyse the prominent predictors from the values of laboratory findings among patients with sepsis. Method and Material: The study was aan analytic observational study with a casecontrol approach. The data were extracted from patients's medical records between 2014 and 2015. This study involved 50 septic patients admitted to Dr. Soetomo General Hospital, Surabaya, Indonesia. Blood urea nitrogen (BUN), creatinine serum, albumin, leukocytes count, haemoglobin, hematocrite, platelets, sodium, potassium, chloride, prothrombin time (PT), and activated partial thromboplastin time (APTT) were collected from blood samples. Logistic regression was used to estimate sepsis related mortalities frequencies and the relationship between laboratory findings and under 28-days mortality. Result and Discussion: From 50 patients, 22 patients were died (44%).The regression model was intially conducted using all three biomarkers as covariates, then using backward elimination, the covariate with the highest pvalue was eliminated. The process was repeated until covariates with statistically significant remained. Multivariate analysis showed that albumin, leukocytes count, and prothrombin time (PT) were the findings associated with high mortality. The independent predictors of mortality identified by further multivariate regression analysis were taken into account as a lower than 3.5 g/dL of albumin, above12.000/µL of leukocytes count, and prolonged more than 14 seconds of prothrombin time; with p value <0,05 respectively (0.029; 0.049; 0.027). Conclusion: Notably, low albumin level, elevated levels of leukocytes, and prolonged prothrombin time were clinically considered as independent predictors of mortality among adult patients with sepsis. ABSTRAKPendahuluan: Sepsis digambarkan sebagai sindrom yang kompleks dan multifaktorial dimana angka morbiditas dan mortalitas tetap tinggi di seluruh dunia. Bukti yang kuat sehubungan dengan faktor prediktif awal untuk mortalitas dan morbiditas jarang tersedia. Tujuan: Tujuan dari penelitian ini adalah untuk menganalisis prediktor yang menonjol dari nilai-nilai temuan laboratorium di antara pasien dengan sepsis. Metode dan Bahan: Penelitian ini merupakan studi observasional analitik dengan pendekatan case-control. Data diambil dari rekam medis pasien antara tahun 2014 dan 2015. Penelitian ini melibatkan 50 pasien sepsis yang dirawat di Rumah Sakit Umum Daerah Dr Soetomo, Surabaya, Indonesia. Blood Urea Nitrogen (BUN), serum kreatinin, albumin, jumlah leukosit, hemoglobin, hematokrit, platelet, natrium, kalium, klorida, prothrombin time (PT), dan activated partial tromboplastin time (APTT) dikumpulkan dari sampel darah. Regresi logistik digunakan untuk memperkirakan tingkat kematian sepsis dan hubungan antara temua...

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Section: Resultsmentioning

confidence: 99%

Albumin, Leukosit, And Protrombin As Predictors Of Sepsis Mortality Among Adult Patients In Soetomo General Hospital, Surabaya, Indonesia

Zharfan

Hakim

Purba

et al. 2019

IJAR

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“…Studies about NPR and PWR indices are very scarce in the literature. Menezes et al (32) have reported that a PWR index of <8 during presentation in sepsis patients was associated with higher mortality in day 4 and day 28. In our study, PWR index was significantly lower in patients at cirrhosis stage.…”

Section: Discussionmentioning

confidence: 99%

Red Cell Volume Distribution Width to Platelet Ratio is an Important Predictor of Liver Fibrosis and Cirrhosis in Chronic Hepatitis B

Hakyemez¹,

Bölükçü²,

Durdu³

et al. 2016

vhd

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ÖZObjective: In recent years, a lot of non-invasive tests have been examined for estimating the severity of liver fibrosis in patients with chronic hepatitis B (CHB). We aimed to evaluate the role of simple and valuable platelet-derived indices in estimating the stage of fibrosis and cirrhosis in patients with CHB. Materials and Methods:A total of 434 biopsy-proven naive CHB patients were included in the study. Liver biopsy samples were examined using the ISHAK scoring system. Age, sex, complete blood count parameters and the stage of fibrosis of the patients were recorded. The patients were evaluated according to the severity of fibrosis (stage 0-2: No fibrosis/mild fibrosis and stage 3-6: Significant fibrosis) and the presence of cirrhosis (stage 0-4: No cirrhosis, stage 5-6: Cirrhosis). Results: Of the 434 patients included in the study, 252 (58.1%) were men and 182 (41.9%) were women. The mean age of the patients was 42.7±12.2 years. Significant liver fibrosis was found in 108 (24.9%) patients and cirrhosis in 43 (9.9%) patients. In dual analysis, alterations in many platelet-derived parameters were observed. Receiver operating characteristic curve analysis revealed that red blood cell distribution width to platelet ratio index was the highest area under the curve value (0.777) in predicting significant liver fibrosis and the cutoff value was 0.0814, sensitivity was 56% and specificity was 87%. Conclusion: Platelet-derived indices may play an important role in observing the progression of liver fibrosis and cirrhosis. Platelet ratio index is significantly increased in advanced liver fibrosis in patients with CHB, and can be defined as independent predicting factor in liver fibrosis. Keywords: Chronic hepatitis B, platelet-derived indices, liver fibrosis, cirrhosisAmaç: Son yıllarda, kronik hepatit B (KHB) hastalarında fibrozis şiddetini tahmin etmek için bir çok non-invaziv test çalışılmıştır. Biz basit ve kullanışlı olan platelet kökenli indekslerin kronik hepatit B (KHB) hastalarında fibrozis düzeyi ve siroza gidişte rolünü araştırmayı amaçladık. Gereç ve Yöntemler: Çalışmaya biyopsi ile kanıtlanmış 434 naif KHB hastası dahil edildi. Karaciğer biyopsi örnekleri İSHAK skorlama sistemi kullanılarak incelendi. Yaş, cinsiyet, tam kan sayım parametreleri ve fibrozis evresine ait hasta verileri kaydedilmiştir. Hastalar, fibrozis şiddeti (evre 0-2: Fibrozis yok/hafif ve evre 3-6: Önemli fibrozis) ve siroz varlığı (evre 0-4: Siroz yok, evre 5-6: Siroz) açısından değerlendirilmiştir. Bulgular: Çalışmaya dahil edilen 434 hastanın, 252'si (%58,1) erkek, 182'si (%41,9) kadındı. Hastaların yaş ortalaması 42,7±12,2 idi. Hastaların 108'inde (%24,9) önemli karaciğer fibrozisi, 43'ünde (%9,9) siroz saptandı. İkili analizlerde platelet temelli birçok parametrede anlamlı değişkenlikler saptanmıştır. Alıcı işletim karakteristiği analizi ile yaptığımız değerlendirmede eritrosit dağılım genişliği/ trombosit indeksini önemli karaciğer fibrozisini öngörmede en yüksek eğri altında kalan alan değeri (0,777) olarak saptadık...

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Platelet/leukocyte ratio as a predictor of mortality in patients with sepsis

Cited by 2 publications

References 1 publication

Albumin, Leukosit, And Protrombin As Predictors Of Sepsis Mortality Among Adult Patients In Soetomo General Hospital, Surabaya, Indonesia

Albumin, Leukosit, And Protrombin As Predictors Of Sepsis Mortality Among Adult Patients In Soetomo General Hospital, Surabaya, Indonesia

Red Cell Volume Distribution Width to Platelet Ratio is an Important Predictor of Liver Fibrosis and Cirrhosis in Chronic Hepatitis B

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