Platelet Lipid Peroxidation in Haemodialysis Patients: Effects of Vitamin E Supplementation

Taccone-Gallucci, M; Lubrano, Riccardo; Principe, Domenico Del; Menichelli, A; Giordani, M.; Citti, G.; Morosetti, Massimo; Meloni, Carlo; Mazzarella, V.; Meschini, L.; Tozzo, C.; Elli, Marco; Giardini, O; Casciani, Cu

doi:10.1093/ndt/4.11.975

Cited by 32 publications

(10 citation statements)

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“…Activation of the leukocytes dur ing the inflammatory reaction increases the generation of free radicals; some of these leak outside the cells and injure surrounding tissues. Because they have an extremely short life-span (a half life of a few milliseconds) free radicals are difficult to measure directly; instead we obtain indirect evidence of their toxic effects on biological tissues by measuring markers of lipid peroxidation, such as malondialdehyde or conjugated dienes [12,13]. In these studies we have found that, in rats infused intraperitoneally over 6 days with saline the concentration of MDA in lipids from the omentum had increased, suggesting that there was an augmented generation of free radicals within the peritoneal cavity.…”

Section: Discussionmentioning

confidence: 99%

Glycosaminoglycan Chondroitin Sulphate Prevents Loss of Ultrafiltration during Peritoneal Dialysis in Rats

Bręborowicz

Wieczorowska

Martis

et al. 1994

Nephron

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We evaluated the effect of 6 days of intraperitoneal saline infusion on peritoneal peroxidation and permeability in rats. Peroxidation of the peritoneum as measured by malondialdehyde concentration in the omentum was increased and there was a concomitant augmented membrane permeability to glucose and resulted in a loss of ultrafiltration. In vitro experiments with mesothelial cells showed that glycosaminoglycan chondroitin sulphate appears to act as a scavenger of free radicals and so protects the mesothelial cells against injury. Thus, in rats, supplementation of the infused saline with chondroitin sulphate reduces peroxidation of the peritoneum and prevents loss of ultrafiltration during peritoneal dialysis. These results suggest that chondroitin sulphate may be effective in preventing the deterioration of peritoneal permeability during chronic peritoneal dialysis. This beneficial effect probably derives from the scavenging of free radicals by chondroitin sulphate.

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Section: Discussionmentioning

confidence: 99%

Glycosaminoglycan Chondroitin Sulphate Prevents Loss of Ultrafiltration during Peritoneal Dialysis in Rats

Bręborowicz

Wieczorowska

Martis

et al. 1994

Nephron

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“…Furthermore, TNF-␣ enhances the DNA binding of Cbfa1/Runx2, activated protein 1, and cAMP responsive element binding protein, which are important transcription factors in osteoblastic differentiation. [81][82][83][84][85][86][87][88][89][90] In addition to the osteogenic transdifferentiation of VSMCs, Demer and colleagues 91,92 highlighted the contributions of pluripotent vascular mesenchymal progenitors to the vascular calcium accrual. Calcifying cells of Demer are mural multipotent mesenchymal progenitors related to the microvascular pericyte.…”

Section: Oxidative Stress and Inflammationmentioning

confidence: 99%

Vascular Calcification

Mizobuchi¹,

Towler²,

Slatopolsky³

2009

Journal of the American Society of Nephrology

471

352

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“…For example, the first five reports published in this area (1984)(1985)(1986)(1987)(1988)(1989)(1990)(1991)(1992) are all from an Italian research group that administered 300 mg/day of intravenous a-tocopherol for 15 days and reported decreases in erythrocyte MDA, 38,39 peripheral blood mononuclear cell MDA, 40 and platelet MDA. 41 Articles from the same trial are highlighted with the same superscript symbol in Table 1.…”

Section: A-tocopherolmentioning

confidence: 99%

Antioxidant therapy in hemodialysis patients: a systematic review

Coombes

Fassett

2012

Kidney International

104

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Antioxidants have been used as therapies to decrease oxidative stress and improve CVD risk in hemodialysis (HD) patients. A systematic search of the Medline database (search date 30 April 2011) found 56 studies investigating the effects of antioxidant therapies on biomarkers of oxidative stress (53 studies) or clinical outcomes (3 studies). The majority were small trials using a nonrandomized open-label design with a single HD group (no HD controls). Alpha-tocopherol was the most investigated antioxidant, with 20/25 studies reporting that this vitamin decreased oxidative stress, and one clinical outcome trial in 196 patients finding that it protected against secondary CVD. Studies using vitamin C were more equivocal, with 4/11 showing decreased oxidative stress and one clinical outcome trial showing no effect on morbidity or mortality. N-acetylcysteine was the most efficacious agent, with 4/4 studies indicating a decrease in oxidative stress and one trial (n=134) showing reduced CVD events. Seven studies have used therapy containing a combination of antioxidants, with five of these reporting decreased oxidative stress. Most intervention studies in HD patients, such as statin therapy and increased dialysis dose, have failed to show improvement in CVD outcomes. Two intervention trials using different antioxidants have found CVD benefits, suggesting that this line of therapy is effective in this resistant population. These studies require validation in larger, adequately powered trials.

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Platelet Lipid Peroxidation in Haemodialysis Patients: Effects of Vitamin E Supplementation

Cited by 32 publications

References 0 publications

Glycosaminoglycan Chondroitin Sulphate Prevents Loss of Ultrafiltration during Peritoneal Dialysis in Rats

Glycosaminoglycan Chondroitin Sulphate Prevents Loss of Ultrafiltration during Peritoneal Dialysis in Rats

Vascular Calcification

Antioxidant therapy in hemodialysis patients: a systematic review

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