Platelet–Lymphocyte Ratio, Neutrophil–Lymphocyte Ratio and Their Dynamic Changes with Type 2 Diabetes Mellitus: A Cohort Study in China

Zhang, Canjia; Chen, Huan; Cui, Shangxin; Lin, Yeli; Liang, Y; Zhao, Ping; Wang, Changyi; Xu, Shan; Peng, Xiaolin; Chen, Hongen; Wang, Li; Zhao, Dan; Zhang, Ming; Hu, Dongsheng; Lou, Yanmei; Hu, Fulan

doi:10.1080/07435800.2022.2127757

Cited by 8 publications

(7 citation statements)

References 47 publications

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“…Elevated MLR has been reported to be a feature not only of COVID‐19 infection but also of diabetic kidney injury, 28 non‐alcoholic fatty liver disease (NAFLD), 29 and cancer 30,31 . Raised PLR has been also reported in other inflammatory conditions including liver fibrosis, 32 thyroid conditions, 33,34 diabetes mellitus, 35 and systemic lupus erythematosus 36 . Increased MPR has been shown to be associated with hepatitis B‐related liver fibrosis, 32 sepsis, 37 and cancer 38 .…”

Section: Discussionmentioning

confidence: 99%

Hematological characteristics of COVID‐19 patients with fever infected by the Omicron variant in Shanghai: A retrospective cohort study in China

Wei

Cheng

et al. 2022

Clinical Laboratory Analysis

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Background A wave of the Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection has rapidly spread in Shanghai, China. Hematological abnormalities have been reported in coronavirus disease 2019 (COVID‐19) patients; however, the difference in hematological parameters between COVID‐19 patients with fever and patients who are febrile from other causes remains unexplored. Methods This retrospective cohort study enrolled 663 SARS‐CoV‐2 positive patients identified by RT‐PCR. Clinical parameters, including age, sex, and threshold cycle values of all COVID‐19 patients, and hematological parameters of COVID‐19 patients in the fever clinic were abstracted for analysis. Results Overall, 60.8% of COVID‐19 patients were male, and the median age was 45 years. Most of COVID‐19 patients were asymptomatic, while 25.8% of patients showed fever and 10.9% of patients had other emergencies. COVID‐19 patients with fever had significantly lower white blood cells (WBCs), neutrophils, lymphocytes, platelets and C‐reactive protein (CRP), and significantly higher monocyte‐to‐lymphocyte ratio (MLR), platelet‐to‐lymphocyte ratio (PLR), mean platelet volume (MPV), and mean platelet volume‐to‐platelet ratio (MPR) levels, compared with those in SARS‐CoV‐2 negative patients with fever from other causes (p < 0.05). Neutrophil‐to‐lymphocyte ratio (NLR), PLR, and systemic inflammatory index (SII) levels were significantly higher in COVID‐19 patients with emergencies (p < 0.05). WBCs showed the best performance with an area under the curve (0.756), followed by neutrophils (0.730) and lymphocytes (0.694) in the diagnosis of COVID‐19 in the fever clinic. Conclusion WBCs, neutrophils, lymphocytes, platelets, CRP and MLR, PLR, and MPR may be useful in early diagnosis of COVID‐19 in the fever clinic.

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Section: Discussionmentioning

confidence: 99%

Hematological characteristics of COVID‐19 patients with fever infected by the Omicron variant in Shanghai: A retrospective cohort study in China

Wei

Cheng

et al. 2022

Clinical Laboratory Analysis

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“…JK Kim et al [10] found that there was a significantly negative relationship between NLR and FPG in normal populations, and in individuals with IFG, there was no significant association. However, in a Chinese cohort study, CJ Zhang [11] reported that larger increase of NLR could increase T2DM risk, and there was a positive relationship between NLR and the risk of T2DM. In our study, we discovered that individuals with elevated NLR had a higher incidence of IFG, indicating a positive correlation between NLR and IFG risk.…”

Section: Discussionmentioning

confidence: 94%

Follow-up study to explore the relationship between Neutrophil to lymphocyte ratio and impaired fasting glucose: using the Group- Based Trajectory Modeling

Liu,

Peng,

Liu

et al. 2024

Preprint

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Background and objective: Previous studies have reported an association between neutrophil to lymphocyte ratio (NLR) and impaired fasting glucose (IFG), but the conclusions were controversial. A follow-up study in the real world can observe the occurrence of diseases and verify the relationship between NLR and IFG. Methods: A total of 1,168 patients without prediabetes or T2DM were followed up for six years. At baseline, participants' NLR levels, fasting plasma glucose and other clinical characteristics were recorded. During the follow-up period, NLR levels and the prevalence of IFG were recorded. Ultimately, 45 individuals were lost to follow-up, leaving 1,123 participants for analysis. Using Group-Based Trajectory Modeling (GBTM), the sample was divided into three groups. Results: The prevalence of IFG in the three groups was 12.1%, 19.4%, and 20.85%, respectively. Compared with the low-level NLR group, the hazard ratio of IFG in the moderate-level NLR group and high-level NLR group were 1.628 (1.109-2.390) and 1.575 (1.001-2.497), respectively, after adjusting for sex, age, and other variables. There was a significant interaction effect of BMI and NLR on the risk of IFG (P < 0.001). Conclusion: In this real-world follow-up study, we observed a positive association between NLR and the risk of IFG, with this relationship being exacerbated by obesity status.

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“…The causes of placental abruption remain unclear, and well-established biomarkers for rapid diagnosis or prediction of the complication are available. Blood routine is easy and inexpensive to measure, these markers as NLR, platelet to lymphocyte ration (PLR) and platelet distribution width (PDW) have been studied in various diseases such as diabetes mellitus, coronary artery disease, ulcerative colitis, and cancer [20][21][22][23]. Recently immerging data is also demonstrating the link between the in ammatory markers NLR value is higher in preeclampsia patients especially in severe preeclampsia [9].…”

Section: Discussionmentioning

confidence: 99%

The potential value of pre-delivery hematologic index in patients with placental abruption and perinatal outcomes

LI,

li,

et al. 2024

Preprint

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Objective This study aimed to clarify the risk factors, clinical features, diagnosis, and management of placental abruption(PA), as well as explore the relationship between the severity of placental abruption and maternal and fetal outcomes. Another purpose of the study was to evaluate changes in hematological biomarkers before delivery in PA and whether their use in predicting the severity of PA. Methods A total of 310 cases of placental abruption among 56,895 women who delivered at our tertiary maternity center between December 2015 and February 2021 were retrospectively analyzed. Patients were classified into four groups based on abruption severity of grade 0, I, II or III, then clinical variables and in hematological biomarkers before delivery were compared among the four groups. The clinic data and pre-delivery hematological biomarkers of placental abruption of different severities were analyzed. Results The incidence of placental abruption in our sample was 0.54%. Primary symptoms of placental abruption included abdominal pain (49.6%), vaginal bleeding (39%), bloody amniotic fluid (24%), abnormal fetal heart rate (16.4%), or no symptoms at all (4.5%). Grade III abruption was significantly more likely to occur than abruption of other grades in patients with preterm delivery, hypertensive disorders in pregnancy, and anemia (P < 0.05). As the severity of placental abruption increased, birth weight and Apgar scores at 1 and 5 min decreased significantly, while the risk of neonatal asphyxia increased significantly. Overall, 0.64% of fetuses had cerebral palsy and 0.96% died. Among mothers, the risk of blood transfusion or cesarean section increased with abruption severity. Pre-delivery hematologic index, the lymphocytes, hemoglobin and fibrinogen decreased significantly(P < 0.05), while the neutrophils, neutrophil to lymphocyte ratio(NLR), prothrombin time(PT) and D-dimer increased significantly with abruption severity(P < 0.05). The variation in the level of coagulation indicators was corresponded to the amount of blood loss during postpartum hemorrhage. Conclusions With increasing severity of placental abruption was associated with adverse maternal and neonatal outcomes. The pre-delivery hematologic index, especially NLR, PT and D-dimer were associated with disease severity, further research should focus on the changes in the hematologic index in PA is critical to reveal the underlying pathophysiologic mechanisms.

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Platelet–Lymphocyte Ratio, Neutrophil–Lymphocyte Ratio and Their Dynamic Changes with Type 2 Diabetes Mellitus: A Cohort Study in China

Cited by 8 publications

References 47 publications

Hematological characteristics of COVID‐19 patients with fever infected by the Omicron variant in Shanghai: A retrospective cohort study in China

Hematological characteristics of COVID‐19 patients with fever infected by the Omicron variant in Shanghai: A retrospective cohort study in China

Follow-up study to explore the relationship between Neutrophil to lymphocyte ratio and impaired fasting glucose: using the Group- Based Trajectory Modeling

The potential value of pre-delivery hematologic index in patients with placental abruption and perinatal outcomes

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