Platelet Markers Correlate with Glycemic Indices in Diabetic, but Not Diabetic-Myelodysplastic Patients with Normal Platelet Count

Abstract

Background: Altered thrombocyte morphology and function have been reported in patients with diabetes mellitus (DM) type 2. The aim of the present study was to determine the associations between platelet morphology markers and hemoglobin A1C (HbA1c), fasting glucose (FG), hypertension and coronary heart disease (CHD) in patients with myelodysplastic syndromes (MDS) and DM, in patients with DM and in controls. Methods: This cross-sectional study included 30 cases with primary MDS with normal platelet count and non-insulin dependent diabetes, 30 non-insulin dependent diabetic patients and 30 non-diabetic, non-MDS controls matched on age and gender. Results: After adjusting for body mass index, platelet number, CHD and hypertension, HbA1c and FG were significant predictors of mean platelet volume (MPV) and platelet distribution width (PDW) in diabetic patients. There was no correlation between platelet parameters and HbA1c or FG in diabetic MDS patients. In controls, FG and hypertension predicted significant differences in platelet morphology. Platelet count correlated with platelet morphology in diabetic MDS and control groups, but not in diabetics. Conclusions: MPV and PDW are associated with glycemic indices in diabetic patients but not in diabetic MDS patients with normal platelet counts. Non-diabetic controls also exhibit FG related changes in platelet morphology. This suggests other factors inherent to bone marrow dysplasia, platelet turnover and biochemistry, or vascular environment affect platelet morphology in diabetic MDS patients even with normal platelet count. Platelet morphology in this population may be an early marker for myelodysplasia. These findings also support platelet morphology change as a marker for elevated macrovascular disease risk.

Platelet mean volume, distribution width, and count in type 2 diabetes, impaired fasting glucose, and metabolic syndrome: a meta‐analysis

“…Moreover, one study included only IGT subjects . Therefore, 39 unique studies were included in the meta‐analysis. Studies characteristics, references, and NOS scores are provided in Table and Supporting Information Table S1 and S2.…”

Altered platelet indices as potential markers of severe and complicated malaria caused by Plasmodium vivax: a cross-sectional descriptive study

“…Thus, PCT is the most neglected haematological parameter in clinical practice and one of the least often reported in publications in the biomedical literature. PCT alterations are observed in some clinical conditions such as coronary ischemia [13], diabetes mellitus [30], pulmonary tuberculosis [31], sleep apnea [32], and inflammatory bowel disease [33]. …”

Mean Platelet Volume is Associated with Glycaemic Control and Retinopathy in Patients with Type 2 Diabetes Mellitus

“…There are several studies indicating the positive relationship between MPV and glycaemic indices, especially FBG and HbA1c (11,12,28). On the other hand, some studies have shown that MPV is not related to FBG and HbA1c (8)(9)(10)13).…”

“…Whether MPV is related to glycometabolic markers such as FBG, PBG and HbA1c is unclear. There is a range of different data about this issue in the literature (8)(9)(10)(11)(12)(13). Also, the relationship between MPV and diabetic microvascular complications remains to be clarified.…”