Platelet Membrane Properties in Alzheimer and Multi-Infarct Dementias

Hicks, Nicholas; Brammer, Michael; Hymas, Nigel; Psych, M. R. C.; Levy, Raymond; Psych, F. R. C.

doi:10.1097/00002093-198701020-00004

Cited by 47 publications

(9 citation statements)

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“…Although we detected quantitative differences in the fatty acid dis tributions between age-mached healthy do nors on one hand, and Alzheimer and multi infarct dementia patients on the other hand, we did not find any significant difference between Alzheimer and multi-infarct de mentia patients (tables 4, 5). The absence of any differences between thrombocyte mem branes from Alzheimer and multi-infarct de mentia patients fits our enzymatic and mor phological data, and the close to normal phospholipid composition of thrombocyte membrane preparations from Alzheimer pa tients [122,123], Separate analysis of pa tients with and without a history of coma (table 1) did not reveal any significant dif ferences between these groups. However, the Alzheimer and multi-infarct dementia groups display differences in degree of corre lation between erythrocyte IgG content and relative content of fatty acids 16:1, 18:0 and 18:2.…”

Section: Membrane Lipidssupporting

confidence: 78%

“…Changes in phospholipid composition may be responsible for the con spicuously aberrant phosphorylation of xproteins [121], Zubenko et al [122] also de scribed an apparent increase in the fluidity of a thrombocyte membrane fraction of a subpopulation of probable Alzheimer pa tients. They ascribe this finding, which has been confirmed later [123], to a microscopi cally visible increase in internal membranes. We do not see this phenomenon after quan titative morphometric analysis of electronmicroscopic photographs of thrombocytes of the 55 patients we have examined so far [Schuurmans Stekhoven et al, in prepara tion].…”

Section: Membrane Lipidsmentioning

confidence: 70%

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Alzheimer’s Disease and Cellular Aging: Membrane-Related Events as Clues to Primary Mechanisms

Bosman

Bartholomeus

Grip³

1991

Gerontology

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A fast-increasing number of data indicate that Alzheimer’s disease is a systemic disease, not restricted to the central nervous system. The nature of Alzheimer-related changes in peripheral cells confirms and emphasizes indications from biochemical and morphological studies in brain for the involvement of cellular membranes in this disease. Analysis of membrane changes in erythrocytes from Alzheimer patients suggests that the normal aging process of these cells is disturbed. These conclusions may form the basis for further studies leading to a better insight into the etiology of Alzheimer’s disease and to the development of diagnostic tools.

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Section: Membrane Lipidssupporting

confidence: 78%

Section: Membrane Lipidsmentioning

confidence: 70%

Alzheimer’s Disease and Cellular Aging: Membrane-Related Events as Clues to Primary Mechanisms

Bosman

Bartholomeus

Grip³

1991

Gerontology

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“…These changes were particularly interesting because alterations in normal ageing occur in the opposite direction . Our group has confirmed this (Hicks et a/., 1987) and shown that in this respect A D patients differ from cases of multi-infarct dementia, in which slight but not significant changes are found. Platelet membrane fluidity is not altered in mania or depression (Zubenko et a/., 1987a).…”

supporting

confidence: 79%

Platelet membrane fluidity, family history, severity and age of onset in Alzheimer's disease

Eagger

Hajimohammadreza²,

Fletcher

et al. 1990

Int J Geriat Psychiatry

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Platelet membrane fluidity values were assessed in three groups of subjects: (1) 15 Alzheimer's disease patients with a first‐degree family history of the disorder; (2) 16 Alzheimer's disease patients with no family history of the disorder; (3) 22 healthy control subjects. The distributions of platelet membrane fluidity changes were found to be the same in both Alzheimer disease groups, but none of the controls had raised platelet membrane fluidity Severity of Alzheimer's disease as measured by Mini‐Mental State and Cambridge Cognitive Index scores correlated with platelet membrane fluidity values significantly for the non‐family history group but not for the family history group. There was no apparent association between raised platelet membrane fluidity and age of onset of Alzheimer's disease. There was no evidence to indicate that raised platelet membrane fluidity is a peripheral marker for familial Alzheimer's disease.

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“…Moreover, increased membrane fluidity has not been found in elderly patients with either depression (Zubenko et al, 1987 c) or multi-infarct dementia (Hicks et al, 1987), and seems thus to constitute an inherited factor related to AD development (Zubenko et al, 1987 d). The membrane structure change may induce physico-chemical alterations in the receptor complexes and enzymes whose function is known to be related to the lipid composition of their immediate surroundings and may be responsible, in some way, for the increased 3 H-IMI binding and MAO B activity we noted.…”

Section: Discussionmentioning

confidence: 99%

Increased platelet 3H-imipramine binding and monoamine oxidase B activity in Alzheimer's disease

Bonuccelli

Piccini

Marazziti

et al. 1990

J Neural Transm Gen Sect

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Several biochemical abnormalities in peripheral tissues have been reported in Alzheimer's disease (AD). With this in mind we studied platelet monoamine oxidase B (MAO B) activity and 3H-imipramine (IMI) binding in both AD patients and healthy subjects and found a significantly higher level of platelet MAO B activity and 3H-IMI Bmax values in the AD patients. In view of the part that MAO B plays in metabolizing serotonin (5HT) and of the relationship which exists between 3H-IMI binding and 5HT uptake, our results would suggest that with AD there occurs a complex dysfunction in the 5HT system, at least at a peripheral level.

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Platelet Membrane Properties in Alzheimer and Multi-Infarct Dementias

Cited by 47 publications

References 0 publications

Alzheimer’s Disease and Cellular Aging: Membrane-Related Events as Clues to Primary Mechanisms

Alzheimer’s Disease and Cellular Aging: Membrane-Related Events as Clues to Primary Mechanisms

Platelet membrane fluidity, family history, severity and age of onset in Alzheimer's disease

Increased platelet 3H-imipramine binding and monoamine oxidase B activity in Alzheimer's disease

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