Platelet Motion near a Vessel Wall or Thrombus Surface in Two-Dimensional Whole Blood Simulations

Skorczewski, Tyler; Erickson, Lindsay Crowl; Fogelson, Aaron L.

doi:10.1016/j.bpj.2013.01.061

Cited by 64 publications

(63 citation statements)

References 31 publications

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“…Modeling the thrombus as a porous structure predicts that the depletion layer narrows with increasing porosity (Skorczewski et al 2013), thus squeezing platelets into the thrombus (Figure 2 e ) and possibly increasing the likelihood of platelet aggregation. Even without interstitial fluid flow through a clot, the presence of a stenosis in a vessel (Figure 2 d ) may enhance platelet deposition (Wang et al 2013a).…”

Section: Platelet Margination In Flowing Bloodmentioning

confidence: 99%

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Fluid Mechanics of Blood Clot Formation

Fogelson

Neeves

2015

Annu. Rev. Fluid Mech.

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263

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Intravascular blood clots form in an environment in which hydrodynamic forces dominate and in which fluid-mediated transport is the primary means of moving material. The clotting system has evolved to exploit fluid dynamic mechanisms and to overcome fluid dynamic challenges to ensure that clots that preserve vascular integrity can form over the wide range of flow conditions found in the circulation. Fluid-mediated interactions between the many large deformable red blood cells and the few small rigid platelets lead to high platelet concentrations near vessel walls where platelets contribute to clotting. Receptor-ligand pairs with diverse kinetic and mechanical characteristics work synergistically to arrest rapidly flowing cells on an injured vessel. Variations in hydrodynamic stresses switch on and off the function of key clotting polymers. Protein transport to, from, and within a developing clot determines whether and how fast it grows. We review ongoing experimental and modeling research to understand these and related phenomena.

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Section: Platelet Margination In Flowing Bloodmentioning

confidence: 99%

“…Platelet motions from three different near-wall starting locations are shown. Panel e modified with permission from Skorczewski et al (2013).…”

Section: Figurementioning

confidence: 99%

Fluid Mechanics of Blood Clot Formation

Fogelson

Neeves

2015

Annu. Rev. Fluid Mech.

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263

202

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“…Several suppositions have emerged in an attempt to explain these observations. The mechanism of self-regulation of thrombosis has been ascribed to biochemical reactions and platelet activation (7,9), the changing porosity of the thrombus (10), or the nonuniform structure of the thrombus (6)(7)(8)(9)(10)(11)(12), but it is still a subject of debate. Early studies demonstrated that thrombosis is governed mainly by two competing factors: the rate of platelet attachment from the bloodstream and the intensity of hydrodynamic forces that prevent platelets from adhering to the thrombus (8,(12)(13)(14)(15)(16)(17).…”

Section: Introductionmentioning

confidence: 99%

Threshold of Microvascular Occlusion: Injury Size Defines the Thrombosis Scenario

Belyaev

Panteleev

Ataullakhanov

2015

Biophysical Journal

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Damage to the blood vessel triggers formation of a hemostatic plug, which is meant to prevent bleeding, yet the same phenomenon may result in a total blockade of a blood vessel by a thrombus, causing severe medical conditions. Here, we show that the physical interplay between platelet adhesion and hemodynamics in a microchannel manifests in a critical threshold behavior of a growing thrombus. Depending on the size of injury, two distinct dynamic pathways of thrombosis were found: the formation of a nonocclusive plug, if injury length does not exceed the critical value, and the total occlusion of the vessel by the thrombus otherwise. We develop a mathematical model that demonstrates that switching between these regimes occurs as a result of a saddle-node bifurcation. Our study reveals the mechanism of self-regulation of thrombosis in blood microvessels and explains experimentally observed distinctions between thrombi of different physical etiology. This also can be useful for the design of platelet-aggregation-inspired engineering solutions.

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“…At normal haematocrit values platelets slide (rather than tumble) through the CFL, with more of their surface exposed to the vessel wall -possibly maximising their probability of adhesion. Using the method of Crowl and Fogelson, Skorczewski et al 77 studied the dynamics of platelets in the CFL at a thrombus site. They found that the CFL is narrowed at the thrombus site, leading to a closer contact between the thrombus and platelets; it is thought that this may enhance the likelihood of platelet adhesion and promote further thrombus growth.…”

Section: Plateletsmentioning

confidence: 99%

Computational fluid dynamics in the microcirculation and microfluidics: what role can the lattice Boltzmann method play?

O’Connor

Day

Mandal

et al. 2016

Integrative Biology

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Patient-specific simulations, efficient parametric analyses, and the study of complex processes that are otherwise experimentally intractable are facilitated through the use of Computational Fluid Dynamics (CFD) to study biological flows. This review discusses various CFD methodologies that have been applied across different biological scales, from cell to organ level. Through this discussion the lattice Boltzmann method (LBM) is highlighted as an emerging technique capable of efficiently simulating fluid problems across the midrange of scales; providing a practical analytical tool compared to methods more attuned to the extremities of scale. Furthermore, the merits of the LBM are highlighted through examples of previous applications and suggestions for future research are made. The review focusses on applications in the midrange bracket, such as cellcell interactions, the microcirculation, and microfluidic devices; wherein the inherent mesoscale nature of the LBM renders it well suited to the incorporation of fluid-structure interaction effects, molecular/particle interactions and interfacial dynamics. The review demonstrates that the LBM has the potential to become a valuable tool across a range of emerging areas in bio-CFD, such as understanding and predicting disease, designing Lab-on-a-Chip devices, and elucidating complex biological processes.

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Platelet Motion near a Vessel Wall or Thrombus Surface in Two-Dimensional Whole Blood Simulations

Cited by 64 publications

References 31 publications

Fluid Mechanics of Blood Clot Formation

Fluid Mechanics of Blood Clot Formation

Threshold of Microvascular Occlusion: Injury Size Defines the Thrombosis Scenario

Computational fluid dynamics in the microcirculation and microfluidics: what role can the lattice Boltzmann method play?

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