Platelet Phospholipids and Their Function in Patients With Ishemic Heart Disease

Nordøy, Arne; Rødset, Johanne Margrete

doi:10.1111/j.0954-6820.1970.tb08016.x

Cited by 36 publications

(3 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The present results, confirm those obtained by Nordoy & Rodset (1970) on the increased activity of PF:< in ischaemic heart disease, despite marked differences in the clotting tests utilized. The present data have been obtained on washed platelets, a technique which eliminates the influence of most of the plasmatic clotting factors.…”

Section: Discussionsupporting

confidence: 91%

“…It has been reported recently by Nordoy & Rodset (1970) that the activity of PF3 was increased in patients with ischaemic heart disease, probably as a result of an enhanced phospholipid content of platelets. Subsequent studies (Nordoy #& Rodset 197 1) have indicated that beta-lipoproteins on the platelet surface might influence PF3 activity in patients prone to coronary disease.…”

mentioning

confidence: 89%

See 1 more Smart Citation

Platelet Factor 3 Activity and Platelet Aggregation in Patients Submitted to Coronarography

Renaud

Gautheron

Arbogast

et al. 1974

Scandinavian Journal of Haematology

View full text Add to dashboard Cite

37 patients submitted to coronarography were compared to 19 controls having no risk factors for coronary heart disease. It was solely in the patients having the most severe lesions that the cholesterol and triglycerides in plasma, and the susceptibility of platelets to thrombin induced aggregation were significantly higher than in the controls. By contrast, all the patients including those in whom significant lesion could not be shown by the arteriography, presented a highly significant increase in the activity of platelet factor 3 activity related in most of the patients, to an in vitro hyper‐coagulability. This enhanced platelet factor 3 activity appears to be related to an increase in the clotting activity of the platelet phospholipids.

show abstract

Section: Discussionsupporting

confidence: 91%

mentioning

confidence: 89%

Platelet Factor 3 Activity and Platelet Aggregation in Patients Submitted to Coronarography

Renaud

Gautheron

Arbogast

et al. 1974

Scandinavian Journal of Haematology

View full text Add to dashboard Cite

show abstract

“…Earlier studies have shown that increased amounts of platelet phospholipids are related to increased PF-3 activity in patients with a high frequency of occlusive vascular diseases (29,30). The present study indicates a relation also between the fatty acid composition of the platelet phospholipids and PF-3 activity.…”

Section: Discussionmentioning

confidence: 99%

The Influence of Dietary Fats on Platelets in Man

Nordøy

Rødset

1971

Journal of Internal Medicine

Self Cite

View full text Add to dashboard Cite

Abstract. Two groups, each of 10 subjects, have been given isocaloric diets for 21 days. The diets were identical with the exception of their fat content. One group was given 40% of the calories as soybean oil, and the other the same amount as MCT oil. Platelet and serum lipids and platelet function tests were evaluated before and after the dietary period. The platelet lipid analysis included estimation of total cholesterol and phospholipids, fractionation of phospholipids by thin layer chromatography and gas liquid chromatographic estimation of the fatty acid and aldehyde composition of the various phospholipids. Platelet function tests included platelet factor‐3 (PF‐3) activity and availability, platelet aggregation induced by collagen, ADP and thrombin and platelet electrophoresis. In subjects given a soybean oil diet a significant reduction in serum total cholesterol and phospholipids occurred. No changes were observed in the platelet cholesterol and phospholipid levels, whereas a significant increase of linoleic acid in choline, ethanolamine and serine phosphoglycerides took place. The relative increase of linoleic acid was most marked in the choline phosphoglycerides. A moderate decrease in palmitic and oleic acids was seen in most phospholipid fractions. PF‐3 activity in platelet‐rich plasma showed a consistent decrease in these subjects, whereas the other platelet function tests showed insignificant changes. In subjects given MCT oil diet no significant changes were observed in serum or platelet lipids, including the phospholipid fatty acids. Increased PF‐3 activity in platelet‐rich plasma exposed to ADP was the only functional disturbance observed in this group.

show abstract

Modifications of Platelet Functions by Dietary Fats

Renaud

1975

Lipids, Lipoproteins, and Drugs

View full text Add to dashboard Cite

Platelet Phospholipids and Their Function in Patients With Ishemic Heart Disease

Cited by 36 publications

References 17 publications

Platelet Factor 3 Activity and Platelet Aggregation in Patients Submitted to Coronarography

Platelet Factor 3 Activity and Platelet Aggregation in Patients Submitted to Coronarography

The Influence of Dietary Fats on Platelets in Man

Modifications of Platelet Functions by Dietary Fats

Contact Info

Product

Resources

About