Platelet Phospholipids and Their Function in Patients with Juvenile Diabetes and Maturity Onset Diabetes

Nordøy, Arne; Rødset, Johanne Margrete

doi:10.2337/diab.19.10.698

Cited by 37 publications

(10 citation statements)

References 4 publications

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“…This study revealed that there were no significant differences between them, as the P value was not less than 0.01 according to the null's hypothesis. Many studies revealed that there some differences in the concentration of lipids and fatty acids [5][6][7][8][9]. But the evidence present now is not sufficient enough to term that there is a relationship between vascular and metabolic diseases cause the evidence obtained via this study also validates the point mentioned above.…”

Section: Discussionsupporting

confidence: 75%

Analysis of Platelet Count in Patients with Bleeding Gums

A¹,

Brundha²

2017

J Clin Exp Pathol

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Aim: The aim of this study is to analyze the platelet count of patients with bleeding gums. Material and methods:50 patients who reported to Saveetha Dental College with a chief complaint of bleeding gums were assessed for their platelet count to find any relationship of bleeding with platelet count. Reason:Platelets play an essential role in arresting bleeding and aids in clotting mechanism by formation of platelet plug. Low platelet count known as thrombocytopenia accounts for a poor or slow clotting mechanism. Thrombocytopenia is due to destruction of platelets in the blood stream, spleen or liver. It can also be due to chemotherapy, radiotherapy, due to intake of certain drugs, autoimmune diseases etc. Since the platelets are essential to arrest bleeding, this study is to reveal the alterations of platelet count in patients with bleeding gums.Results: This study highlights the fact that there is no significant difference in the platelet count in patients with bleeding gums.

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Section: Discussionsupporting

confidence: 75%

Analysis of Platelet Count in Patients with Bleeding Gums

A¹,

Brundha²

2017

J Clin Exp Pathol

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“…Platelet phospholipids have already been found to be abnormal in juvenile diabetes. 16 Increased viscosity of diabetic erythrocytes would have little effect in large vessels, where the deformability of the individual red cells is not a major factor in flow. But as the red cell enters smaller and smaller vessels in the microcirculation, its ability to deform becomes important.…”

Section: Resultsmentioning

confidence: 99%

Reduced Erythrocyte Deformability in Diabetes

1978

Diabetes

338

161

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The flow properties of individual erythrocytes have been studied in glass micropipets 4 \x in internal diameter. The pressure gradient required to establish a standard oscillatory movement over a 130-/x path in a three-second time period was measured in paired studies comparing diabetic and control erythrocytes suspended in Ringer solution. The pressure requirement was regularly elevated for the diabetic erythrocytes, averaging 50 per cent greater than the controls. Studies of erythrocytes comparing alloxan-diabetic rats with control rats demonstrated a similar elevation in required pressure. Red cells from subjects with hereditary spherocytosis offered less flow resistance than diabetic cells, and red cells from rheumatoid arthritics required no pressure increment. When erythrocytes are ejected from a 4-/x micropipet they return quickly to a discoid shape using stored elastic energy. Slow motion photography revealed that diabetic erythrocytes restore their shape less rapidly than nondiabetic erythrocytes, indicating that their reduced deformability is due to an elevation of either intraerythrocyte or membrane viscosity rather than to increased resistance to bending. Diabetes is regularly associated with an increased intracellular hemoglobin Ale; it is possible that hemoglobin Ale could raise intraerythrocyte viscosity. The observed disturbance in flow properties of individual erythrocytes is subtle. It would affect the flow of blood, particularly through active muscle, and modify the pressure exerted by individual erythrocytes on the muscle capillary wall.DIABETES 27:895-901, September, 1978.

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“…Further studies are needed to elucidate the degree to which alterations in prostanoid metabolism of diabetic patients [12][13][14][15][16][17][18][19][20] are based on disturbances in the synthesis of the precursor PUFA.…”

Section: Discussionmentioning

confidence: 99%

“…In fact, several abnormalities of the platelet function and prostaglandin metabolism have been described in human diabetes [12][13][14][15]. Cross-sectional studies have shown that ARA-content of diabetic platelets may be increased [17,18], normal [19] or decreased [20], the latter especially in cases with severe retinopathy [201. We have recently observed that in women with Type 1 diabetes the content of linoleic acid of serum lipids was higher and that of ARA and other n-6 PUFA lower than in controls [3].…”

mentioning

confidence: 99%

Improvement of diabetic control by continuous subcutaneous insulin infusion therapy changes fatty acid composition of serum lipids and erythrocytes in Type 1 (insulin-dependent) diabetes

1986

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Summary. The influence of improved diabetic control on the fatty composition of serum lipids, erythrocytes and platelets was investigated in 24patients with Type 1 (insulin-dependent) diabetes treated for 6 months with either continuous subcutaneous insulin infusion (n = 14) or conventional insulin therapy (n = 10). The groups were matched for age, sex, body mass index, serum lipids, duration of diabetes, glycosylated haemoglobin and insulin dose. Glycaemic control improved, and the contents of dihomogammalinolenic acid and arachidonic acid but not linoleic acid rose significantly (p < 0.05), in serum lipids of patients treated with continuous infusion. No changes were observed in the group treated with insulin injections. Both in serum and erythrocytes the n-6 polyunsaturated fatty acid ratios rose consistently in the patients, with improvement of control regardless of the mode of treatment. Furthermore, the change of HbA1 was negatively correlated with that of arachidonic acid in erythrocytes. No changes were found in the platelet fatty acid compositions. The findings suggest that improved diabetic control enhances the conversion of linoleic acid to arachidonic acid, probably by activating enzymes needed for chain elongation and desaturation.

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Platelet Phospholipids and Their Function in Patients with Juvenile Diabetes and Maturity Onset Diabetes

Cited by 37 publications

References 4 publications

Analysis of Platelet Count in Patients with Bleeding Gums

Analysis of Platelet Count in Patients with Bleeding Gums

Reduced Erythrocyte Deformability in Diabetes

Improvement of diabetic control by continuous subcutaneous insulin infusion therapy changes fatty acid composition of serum lipids and erythrocytes in Type 1 (insulin-dependent) diabetes

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