Platelet Production in the Lungs

Jf, Martín; Dn, Slater; Ea, Trowbridge

doi:10.1007/978-3-0348-7451-9_3

Cited by 6 publications

(5 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recent studies have suggested that platelets play a role in the allergic inflammatory response and airway remodeling (18)(19)(20). Identification of the presence of megakaryocytes in the lungs has been the premise of platelet studies in airway disorders (21). It was then detected that the platelet count was higher in the lungs than in the blood and this was associated with platelet production in lungs (22).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Platelet Activation During an Asthmatic Attack in Children

KARA¹,

ÖZBEK²,

KÖKSAL³

2015

Turkish J Pediatr Dis

View full text Add to dashboard Cite

Original Article Özgün Araştırma (3). As an inflammatory disease, mast cells, eosinophils, T lymphocytes, dendritic cells, macrophages and neutrophils may play a role in the pathogenesis of asthma (4,5). In vitro studies have shown that platelets also have an important role in inflammatory processes (6). When platelets are activated, increased surface receptor expression together with secretion of a variety of inflammatory molecules that contribute to the immune response and inflammation occur (7,8). Structural and volumetric changes in platelets may guide the differential INTRODuCTION Asthma is the most common chronic disease of the childhood (1). It affects about 300 million people in the world. According to the latest data on prevalence, cumulative asthma frequency varies between 13.7 and 15.3% in our country (2). Chest tightness, shortness of breath, repeated wheezing and cough are the important clinical features of asthma. These episodes are associated with variable airway narrowing and are usually reversed either spontaneously or with treatment ABSTRACT Objective: Asthma is a chronic inflammatory disease of the airways. Allergic inflammation is characterized by accumulation of various cells, particularly mast cells, eosinophils, T lymphocytes and platelets. We investigated whether changes in mean platelet volume (MPV), platelet distribution width (PDW), plateletcrit (PCT) and p-selectin levels of children with asthma during and at least 1 month after the attack can be used as a marker. Material and Methods: The study was performed in 40 children who suffered asthma attacks. Blood samples were taken for MPV, PDW, PCT, p-selectin, eosinophil and platelet values during and at least 1 month after the attack. Results: Mean platelet volume, PCT, and p-selectin levels were significantly lower at the time of the attack when compared to those at least 1 month after the attack. Conclusion: Our findings suggest that MPV and PCT, common parameters in routine practice, can be used to determine an asthma attack.

show abstract

Section: Discussionmentioning

confidence: 99%

Evaluation of Platelet Activation During an Asthmatic Attack in Children

KARA¹,

ÖZBEK²,

KÖKSAL³

2015

Turkish J Pediatr Dis

View full text Add to dashboard Cite

show abstract

“…8 Each MK produces about 1000 to 2000 platelets, probably by cytoplasmic fragmentation of MKs in the pulmonary circulation. 9 Measurements of platelet and MK parameters in man suggest that they are so closely linked that they can be considered a single system: the megakaryocyte-platelethaemostatic axis (MPHA) (reviewed in ref. 10).…”

Section: The Megakaryocyte-platelet-haemostatic Axismentioning

confidence: 99%

Platelets and stroke

1999

View full text Add to dashboard Cite

Platelets are anucleate cells with little or no capacity for de novo protein synthesis. Their potential haemostatic reactivity is established at or before thrombopoiesis by their precursor cell, the bone marrow megakaryocyte. In some pathologic conditions, the megakaryocyte-platelet-haemostatic axis (MPHA) becomes perturbed, resulting in the formation of hyperfunctional platelets which may contribute to the development of vascular disease or an acute thrombotic event such as ischaemic stroke or myocardial infarction. Laboratory measurements of platelet function have established that platelet reactivity is accentuated in acute ischaemic stroke, particularly following cortical rather than lacunar infarction. Whether accentuated platelet function is a cause or a consequence of stroke is not yet clear, but it is likely that patients with certain risk factor profiles have some degree of platelet activation preceding the stroke. Further work into the MPHA is required to establish whether enhanced post-stroke platelet reactivity can be referred to the megakaryocyte. The antiplatelet agents tested to date are effective in secondary but not primary prevention of stroke. This probably reflects the diverse pathophysiology of stroke: accentuated platelet function is only likely to be a significant factor in cortical stroke.

show abstract

“…Moreover, platelets were found to accumulate in the pulmonary microvasculature and were detected in BAL fluid of patients undergoing bronchial provocation with al¬ lergens,1415 and many abnormal megakaryocytes were reportedly observed in lung tissues removed at autopsy from patients who died of status asthmati¬ cus. 16 These previous reports concerning platelets in bronchial asthma have focused on their aggregation, release of PF4 and (3-thrombogloblin, or accumula¬ tion in lung, whereas few reports have investigated intracellular calcium movement in platelets or re¬ lease of RANTES.…”

mentioning

confidence: 99%