2003
DOI: 10.1002/jbm.a.10154
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Platelet responses and coagulation activation on polylactide and heparin–polycaprolactone‐L‐lactide ‐coated polylactide stent struts

Abstract: Despite modern stent technology and effective antiplatelet therapy, metallic stents carry the risk of (sub)acute thrombosis. Our aim was to examine short-term differences in platelet deposition and coagulation activation between biodegradable polylactide (PLA), heparin-polycaprolactone-L-lactide-coated polylactide (hepa-P(CL95/L-LA5)-PLA), and stainless steel (SS) stent struts. Gel-filtered platelets (GFP) and platelet-rich plasma (PRP) were labeled with 10 nM (3)H-serotonin. Platelet deposition was measured a… Show more

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Cited by 15 publications
(20 citation statements)
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“…A great number of platelets adhered on the surface of PLLA, PCL, PLLA‐TMC, and PDLLA‐TMC films. Activation of platelets was observed by SEM, in agreement with literature data on PLA and PCL 37–41. In contrast, less platelets and lower activation were found on PTMC, while PCL‐TMC exhibited the lowest degree of activation with few adhered platelets.…”
Section: Discussionsupporting
confidence: 89%
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“…A great number of platelets adhered on the surface of PLLA, PCL, PLLA‐TMC, and PDLLA‐TMC films. Activation of platelets was observed by SEM, in agreement with literature data on PLA and PCL 37–41. In contrast, less platelets and lower activation were found on PTMC, while PCL‐TMC exhibited the lowest degree of activation with few adhered platelets.…”
Section: Discussionsupporting
confidence: 89%
“…E‐PLCL significantly suppressed the migration and invasion of VSMCs as well as the adhesion and activation of platelets. Hietala et al investigated platelet deposition on steel and PLA stents 39, 40. More platelets deposited on PLA stents than on steel ones.…”
Section: Discussionmentioning
confidence: 99%
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“…26 There are many studies about heparan-sulfates grafted onto the surface materials (i.e., heparinized PET, 22 silicon surfaces, 27 and so forth), which have been used for the development of medical devices such as prosthesis, 28,29 and stents. 30,31 In this regard, dermatan sulfate an heparan sul-fate derivative purified from mammalian or marine origins, exhibited anticoagulant properties and can overcome some of the heparin drawbacks (i.e., bleeding). 32,33 In this study, we used sharkskin dermatan sulfate (DS) an easily and low-priced heparan-sulfate with an anticoagulant properties in solution.…”
Section: Discussionmentioning
confidence: 99%
“…The estimated heparin content per stent assessed by Blyscan glycosaminoglycan assay ® (Biocolor Ltd., Belfast, Northern Ireland) was 8.7 µg for the spiral-coated PLA stent, 6.0 µg and 8.3 µg for the two Hepa P(CL/L-LA)-coated PLA stents used in Experiment II, and 11.4 µg for the braided P(CL/D,L-LA)-heparin-coated PLA stents applied in Experiments III and IV. Both heparin-coating methods lead to rapid partial release of heparin, with, however, the surface retaining its antithrombin enhancing activity (32).…”
Section: Heparin-coating Of Biodegradable Stentsmentioning
confidence: 99%