Platelet-rich concentrates (L-PRF, PRP) in tissue regeneration: Control of apoptosis and interactions with regenerative cells

Crisci, Alessandro; Crescenzo, Ugo de; Crisci, Michela

doi:10.15761/jcmm.1000116

Cited by 27 publications

(22 citation statements)

References 18 publications

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“…Its fluid like state enables delivery to the target site by needle injection. Once activated, L-PRP forms a gel and releases most of the growth factors in the first few hours post injection until fully dissolved within 3 days [ 20 ]. It supports growth factors to act as an assembly of platelets and leukocytes in a complex matrix.…”

Section: Discussionmentioning

confidence: 99%

Short-Term Outcomes of Percutaneous Trephination with a Platelet Rich Plasma Intrameniscal Injection for the Repair of Degenerative Meniscal Lesions. A Prospective, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Study

Kaminski

Maksymowicz-Wleklik

Kulinski

et al. 2019

IJMS

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Meniscal tears are the most common orthopaedic injuries, with chronic lesions comprising up to 56% of cases. In these situations, no benefit with surgical treatment is observed. Thus, the purpose of this study was to investigate the effectiveness and safety of percutaneous intrameniscal platelet rich plasma (PRP) application to complement repair of a chronic meniscal lesion. This single centre, prospective, randomized, double-blind, placebo-controlled study included 72 patients. All subjects underwent meniscal trephination with or without concomitant PRP injection. Meniscal non-union observed in magnetic resonance arthrography or arthroscopy were considered as failures. Patient related outcome measures (PROMs) were assessed. The failure rate was significantly higher in the control group than in the PRP augmented group (70% vs. 48%, P = 0.04). Kaplan-Meyer analysis for arthroscopy-free survival showed significant reduction in the number of performed arthroscopies in the PRP augmented group. A notably higher percentage of patients treated with PRP achieved minimal clinically significant difference in visual analogue scale (VAS) and Knee injury and Osteoarthritis Outcome Score (KOOS) symptom scores. Our trial indicates that percutaneous meniscal trephination augmented with PRP results in a significant improvement in the rate of chronic meniscal tear healing and this procedure decreases the necessity for arthroscopy in the future (8% vs. 28%, P = 0.032).

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Section: Discussionmentioning

confidence: 99%

Short-Term Outcomes of Percutaneous Trephination with a Platelet Rich Plasma Intrameniscal Injection for the Repair of Degenerative Meniscal Lesions. A Prospective, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Study

Kaminski

Maksymowicz-Wleklik

Kulinski

et al. 2019

IJMS

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“…Platelets-anucleate cells in the blood-have generally been thought of for their role in hemostasis. In recent years we have learned more about the role of platelets in inflammation and tissue repair [16]. We have learned that platelets are far more intricate-containing multiple proteins which are secreted from their alpha granules during activation and resulting in over 1500 bioactive factors which can participate in tissue repair and immune system modulation [17].…”

Section: Platelet Rich Plasma-platelet Concentratementioning

confidence: 99%

“…Platelets can be quickly isolated and activated from peripheral whole blood using specialized centrifugation and returned to the patient's peripheral circulation the same day. Activated platelets release beneficial chemokines and growth factors that aid in coordinating the healing process [16]. Chemokines released from activated platelets also promote the recruitment, adherence, and proliferation of adult stem cells to further aid in tissue repair.…”

Section: Platelet Rich Plasma-platelet Concentratementioning

confidence: 99%

Longitudinal Assessment of FEV1 Change Following Autologous Cellular Therapy

Rubio¹

2021

JRMBR

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Objective: Current pharmacologic management of Chronic Obstructive Pulmonary Disease (COPD) is aimed at improving symptoms and preventing exacerbations, yet none can alter the natural progression of lung function decline typical of the disease. Autologous-derived PRP-PC may prevent lung function decline and improve quality of life.Methods: 281 patients with COPD underwent autologous cellular therapy with PRP-PC. Baseline lung function and quality of life data were collected and re-assessed after 3 months and after at least 12 months and compared to baseline.Results: Participants undergoing autologous cellular therapy with PRP-PC had a and clinically significant increase in lung function after both 3 months and after at least one year with along with a significant improvement in subjective quality of life from baseline. Compared with findings in the literature that FEV1 typically declines over time, participants in this study had a significant increase in lung function on average. Conclusion:Innovative treatments such as autologous cellular therapy can be a safe, effective option for preventing lung function decline over time. These therapies should be an option for patients where pharmacologic management has failed, or as an adjunct treatment.

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“…This blood concentrate is gotten from the patient's fringe blood after one-step centrifugation without anticoagulants to produce a platelet-and leucocyte-rich framework. The presence of platelets, leucocytes, and fibrin was recently demonstrated to be basic for wound healing [3,4]. Furthermore the capability of leucocytes to impact angiogenesis and lymphomagenesis, this fibrin network, containing leucocytes and platelets, is the basis of cytokines and growth factors, which are primary membranes during the process of injury healing [5].…”

Section: Introductionmentioning

confidence: 99%

“…These cells, together with neutrophils and platelets, are key membranes in wound healing and in mix with their growth factors/discharged cytokines can encourage tissue restoration, the solution of fresh blood vessels (angiogenesis) and the infection prevention. The prevention of infections can be explained by the action of phagocytosis and apoptosis, which have the function of killing infectious cells and necrotic cell residues [3].…”

Section: Introductionmentioning

confidence: 99%

L-PRF Membrane (Fibrin Rich in Platelets and Leukocytes) and Its Derivatives (A-PRF, i-PRF) are Helpful as a Basis of Stem Cells in Regenerative Injury Treatment: Trial Work on the Horse

Crisci

Barillaro

Lepore³

et al. 2020

IBRR

Self Cite

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Developing a multidisciplinary field of tissue engineering aims to recover, improve or supplant typically damaged or missing tissues for a collection of conditions brought about by trauma, malady and old age. To guarantee that tissue engineering techniques are generally relevant in the clinical setting, it is important to adjust them so that they are promptly accessible and moderately simple to use in the everyday clinical schedule. Consequently, the steps between preparation and application must be limited and improved to make them practical in application. The general objective of creating platelet concentrates of natural origin can be delivered near the patient to quicken the implantation procedure, being monetarily practical for the patient and the health framework. Fibrin rich in platelets and leukocytes (PRF) and its derivatives (L-PRF, A-PRF, i-PRF) has been utilized in a wide collection of medical fields for delicate tissue restoration. Practically all platelets (> 97%) are missing within test-tubes in groups tested after PRF membrane extraction. Growth Factors liberated by platelets contained in derivatives of L-PRF induce and control the proliferation and migration of other cell types, associated with tissue repair, similar to smooth cell muscles (SMCs) and mesenchymal stem cells (MSCs). Conclusively, the outcomes of this work feature the positive effects of PRF on wound healing after regenerative treatment for the administration of different delicate tissue defects found in wound care.

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Platelet-rich concentrates (L-PRF, PRP) in tissue regeneration: Control of apoptosis and interactions with regenerative cells

Cited by 27 publications

References 18 publications

Short-Term Outcomes of Percutaneous Trephination with a Platelet Rich Plasma Intrameniscal Injection for the Repair of Degenerative Meniscal Lesions. A Prospective, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Study

Short-Term Outcomes of Percutaneous Trephination with a Platelet Rich Plasma Intrameniscal Injection for the Repair of Degenerative Meniscal Lesions. A Prospective, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Study

Longitudinal Assessment of FEV1 Change Following Autologous Cellular Therapy

L-PRF Membrane (Fibrin Rich in Platelets and Leukocytes) and Its Derivatives (A-PRF, i-PRF) are Helpful as a Basis of Stem Cells in Regenerative Injury Treatment: Trial Work on the Horse

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