Platelet rich fibrin combined with decalcified freeze-dried bone allograft for the treatment of human intrabony periodontal defects: a randomized split mouth clinical trail

Agarwal, Ashish; Gupta, Neelima; Jain, Avikal

doi:10.3109/00016357.2015.1035672

Cited by 99 publications

(89 citation statements)

References 38 publications

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“…In humans, the addition of PRF to DFDBA significantly enhanced bone regeneration compared to with bone graft alone in the treatment of intrabony periodontal defects 2,7,44,49) . It also has the additional benefit of preserving ridge width and height at intervals of 90 to 180 days 54) .…”

Section: Discussionmentioning

confidence: 99%

Effect of PRF and Allograft Use on Immediate Implants at Extraction Sockets with Periapical Infection —Clinical and Cone Beam CT Findings—

Medikeri

Meharwade

Wate

et al. 2018

Bull. Tokyo Dent. Coll.

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Immediate implant placement can be successful, even at infected sites. The adjunctive effects of concomitant use of platelet-rich fibrin (PRF) and decalcified freeze-dried bone allografts (DFDBA) at periapically infected sites remains to be determined, however. The purpose of this prospective study was to investigate the effect of combined use of PRF and DFDBA on immediate implant survival at tooth extraction sites exhibiting periapical lesions. Implants were immediately placed in 8 patients under a standard chemotherapeutic protocol. Adin titanium implants were used in all cases. The combination of PRF and DFDBA was used to fill the gap between the implant body and the surrounding socket wall. The final restoration was placed after 3 months. The full-mouth plaque, gingival bleeding index, and gingival esthetics scores were assessed at 3, 6, and 12 months. Cone beam computed tomography images obtained at baseline and at 12 months after implant loading were analyzed. The plaque index scores showed statistically significant differences at 3, 6, and 12 months (p<0.05). The gingival bleeding index score showed no significant difference. No difference was noted in buccal gingival level on the implant surface or adjacent teeth at 91.7% of sites. Complete closure of the interproximal space was seen in 91.7% of the implant sites. Crestal bone levels on all implant surfaces were non-significant. Implant survival was 91.67% at 12 months. The adjunctive use of PRF with DFDBA at periapically infected sites yielded a significant reduction in bone resorption and accelerated bone healing during the initial post-extraction stage. A significant improvement was achieved in the gingival esthetic score at the interproximal and midfacial surfaces. The combined use of growth factors with pre-and postoperative broadspectrum antibiotics over a short time resulted in a higher implant survival rate at the end of the 1 year post-restoration period.

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Section: Discussionmentioning

confidence: 99%

Effect of PRF and Allograft Use on Immediate Implants at Extraction Sockets with Periapical Infection —Clinical and Cone Beam CT Findings—

Medikeri

Meharwade

Wate

et al. 2018

Bull. Tokyo Dent. Coll.

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“…In contrast, Kim et al20 reported that PRF and CGF showed similar new bone formation in rabbit-skull defect healing. The additional use of PRF with bone grafts and collagen membranes has been demonstrated to increase PD reductions and CAL gain and enhance the periodontal regeneration of intrabony defects 34,35. The additional use of PRF with bone grafts and collagen membranes has been demonstrated to increase PD reductions and CAL gain and enhance the periodontal regeneration of intrabony defects 34,35.…”

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confidence: 99%

Regenerative surgical treatment of peri‐implantitis using either a collagen membrane or concentrated growth factor: A 12‐month randomized clinical trial

İşler

Soysal

Ceyhanlı

et al. 2018

Clin Implant Dent Rel Res

109

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“…8,9 PRF has been used in different surgical procedures such as sinus floor augmentation, treatment of gingival recession (GR), furcation defects, maxillary rehabilitation before implant placement, restoration of peri-implant defects, as well as healing of extraction sockets with promising results. 10,11,12,13,14 In addition, certain clinical studies have been conducted on the use of PRF for treatment of intra-bony defects in humans, 15,16,17,18,19 but none have investigated its additive effects with ABBM for treatment of intra-bony defects. Thus, the present split-mouth, single-centre, controlled study aimed to compare the healing of intra-bony defects treated with a combination of ABBM-PRF or ABBM alone; the hypothesis being tested was that PRF would augment the regenerative effects of ABBM in human intra-bony defects.…”

Section: Introductionmentioning

confidence: 99%

Effects of platelet-rich fibrin on healing of intra-bony defects treated with anorganic bovine bone mineral

et al. 2017

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Anorganic bovine bone mineral (ABBM) is extensively used in the treatment of intra-bony defects. Platelet-rich fibrin (PRF) is a new-generation platelet concentrate with a simplified technique. Although certain studies have reported the use of PRF in the treatment of intra-bony defects, to date, none of them have evaluated its additive effects with ABBM. Therefore, a randomised, split-mouth clinical trial was conducted to compare healing of intra-bony defects treated with an ABBM-PRF combination with healing of those treated with ABBM alone. By using a split-mouth design, 15 paired intra-bony defects were randomly treated with either ABBM alone (control group) or ABBM-PRF combination (test group). Following clinical parameters and radiographical measurements were recorded at baseline and 6 months after treatment: plaque index (PI), gingival index (GI), probing depth (PD), gingival recession (GR), clinical attachment level (CAL), vertical bone loss, depth of defect and defect angle. Preoperative clinical and radiographical measurements were similar for the test and control groups. Statistically significant reductions in GI, PD, CAL, vertical bone loss, depth of intra-bony defect and widening of defect angle were detected after treatment in both groups. With respect to inter-group analysis, gain in CAL was significantly greater in the test group than in the control group, whereas no inter-group differences were observed in any other parameter. The results of this study indicate that both therapies are effective in the treatment of intra-bony defects.

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Platelet rich fibrin combined with decalcified freeze-dried bone allograft for the treatment of human intrabony periodontal defects: a randomized split mouth clinical trail

Abstract: Observations indicate that a combination of PRF and DFDBA is more effective than DFDBA with saline for the treatment of infrabony periodontal defects.

Cited by 99 publications

References 38 publications

Effect of PRF and Allograft Use on Immediate Implants at Extraction Sockets with Periapical Infection —Clinical and Cone Beam CT Findings—

Effect of PRF and Allograft Use on Immediate Implants at Extraction Sockets with Periapical Infection —Clinical and Cone Beam CT Findings—

Regenerative surgical treatment of peri‐implantitis using either a collagen membrane or concentrated growth factor: A 12‐month randomized clinical trial

Effects of platelet-rich fibrin on healing of intra-bony defects treated with anorganic bovine bone mineral

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