Platelet‐Rich Fibrin in Regeneration of Intrabony Defects: A Randomized Controlled Trial

Patel, Gauresh Kumar; Gaekwad, Shivali S.; Gujjari, Sheela Kumar; Kumar, Sheela

doi:10.1902/jop.2017.130710

Cited by 63 publications

(76 citation statements)

References 26 publications

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“…This finding could have been because of the placement of the PRF over the graft which in turn, separated and stimulated the interface between the gingival tissue and the root surface preventing epithelial migration. This helps to maintain the flap in a high and stable position, enhances neoangiogenesis and reduces the necrosis and shrinkage of the flap, thus providing maximal root coverage . These findings explain the biologic rationale for the use of a combination of BG and PRF.…”

Section: Discussionmentioning

confidence: 79%

Clinical and radiographic evaluation and comparison of bioactive bone alloplast morsels when used alone and in combination with platelet‐rich fibrin in the treatment of periodontal intrabony defects—A randomized controlled trial

Bodhare

Kolte

et al. 2018

Journal of Periodontology

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Background: The present study aims to evaluate and compare the clinical and radiographic changes obtained through Bioactive Glass (BG) with and without autologous platelet-rich fibrin (PRF) in the treatment of intrabony defects in chronic periodontitis patients. Methods:The present study was a split-mouth randomized controlled clinical trial comprising 20 chronic periodontitis patients (mean age: 35.9 years) having at least one pair of bilateral intrabony defect. Group 1 included 20 sites treated with a combination of BG and autologous PRF whereas 20 sites in Group 2 were treated with BG alone. Probing pocket depth (PPD), clinical attachment level (CAL) and gingival recession (GR) were evaluated at 3 and 6 months and bone fill at 6 months by using cone beam computed tomography (CBCT) analysis. Primary study outcomes were changes in PPD, CAL, GR, and bone fill.

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Section: Discussionmentioning

confidence: 79%

Clinical and radiographic evaluation and comparison of bioactive bone alloplast morsels when used alone and in combination with platelet‐rich fibrin in the treatment of periodontal intrabony defects—A randomized controlled trial

Bodhare

Kolte

et al. 2018

Journal of Periodontology

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“…15 These fundamental features make PRF an excellent healing biomaterial, 15 being recommended as an adjunct tool for the healing of bone defects. 12 In the present case, PRF was used as coagulum. Additional bone grafts were not used due to the risk of contamination, once the lack of sufficient soft tissue would not allow healing by first intention.…”

Section: Discussionmentioning

confidence: 97%

“…Besides performing piezosurgery, we decided to fill the bone defect with PRF, which consists of an autologous hemo‐component composed of fibrin matrix, leukocytes, cytokines, circulating stem cells, and high amounts of platelets, favoring the development of new blood vessels, migration of neutrophils and macrophages to the injury site, and epithelial coverage . These fundamental features make PRF an excellent healing biomaterial, being recommended as an adjunct tool for the healing of bone defects . In the present case, PRF was used as coagulum.…”

Section: Discussionmentioning

confidence: 99%

“…a ). Afterwards, the bone defect was filled with PRF obtained from the patient's blood before the start of the surgical procedure as follows: ten milliliters of blood were drained from the patient's antecubital vein using a 15‐mL glass tube, which was instantaneously centrifuged at 3,000 rpm for 10 minutes with no anticoagulant. The tube exhibited the plasma on the top, the PRF on the middle, and the red corpuscle layer on the bottom.…”

Section: Case Managementmentioning

confidence: 99%

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Giant Peripheral Ossifying Fibroma Treated With Piezosurgery and Platelet‐Rich Fibrin: A Rare Case Report

Freire

Silva

Pereira³

et al. 2018

Clin Adv Periodontics

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Introduction The peripheral ossifying fibroma (POF) is a benign reactive lesion that exclusively arises from gingiva. The lesion may gain considerably large sizes and present peculiar clinical and radiographic features that would then allow it to be called a giant POF; in that case, its otherwise simple surgical extraction could create a challenge. Thus, we elect here, for the very first time, a plausible alternative for treating giant POF: piezosurgery followed by placement of platelet‐rich fibrin (PRF). Case Presentation A 31‐year‐old black male presented a large asymptomatic nodule on the lower gingiva; the lesion had caused vestibular displacement of teeth and had been present for 18 years. Following the diagnostic hypothesis of a giant POF, an excisional biopsy was performed under local anesthesia using piezosurgery (microvibration of 36,000 times/sec was used in a bone cortical working mode), which confirmed the diagnosis. The surgical procedure was facilitated with the use of piezosurgery followed by placement of PRF, being the trans‐ and postoperative periods occurred with no complications. One year after the treatment, the patient shows no signs of disease recurrence and remains under follow‐up. Conclusions Giant POF is a rare gingival reactive lesion that can reach large dimensions, causing teeth displacement, functional, and esthetic impairments. The lesion can be successfully managed with piezosurgery and PRF, as illustrated herein, avoiding extensive bone loss and damage to the surrounding soft tissues.

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“…Periodontal regeneration in the treatment of IBDs is more likely to succeed as compared with the treatment of furcation defects. Patel et al 251 looked at the use of PRF in the treatment of IBDs and assessed the adjunctive use of PRF in the regenerative management of IBDs in comparison with open flap debridement (OFD). Twenty-six bilateral defects (13 per group) in 13 patients were randomized as either PRF (test group) or OFD alone (control group) sites.…”

Section: Periodontal Regenerationmentioning

confidence: 99%

Annual review of selected scientific literature: A report of the Committee on Scientific Investigation of the American Academy of Restorative Dentistry

Donovan

Marzola²,

Murphy³

et al. 2018

The Journal of Prosthetic Dentistry

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In 2017, professional literature germane to the clinical practice of prosthodontics was published at an astounding rate. The annual content of over 50 professional journals was searched in its entirety to arrive at this review intended to provide readers with a general clinical update. For convenience, prosthodontics has been divided into 8 subtopics: general prosthodontic considerations, conventional removable complete prosthodontics, conventional removable partial prosthodontics, conventional fixed prosthodontics, general implant prosthodontic considerations, implant removable prosthodontics, implant-fixed prosthodontics, and prosthodontic materials. In addition to the articles selected for review, a sizable volume of excellent general reviews, systematic reviews, meta-analyses, and helpful clinical descriptive materials were also published on topics of prosthodontic interest. Although it would be impractical to provide detailed comments on this voluminous additional material, it is listed here for the reader's convenience: clinical processes, 1-7 anatomy and physiology, 8-20 biomechanics, 21 bruxism, 22-25 conventional complete dentures, 26-28 conventional fixed prosthodontics, 29-33 conventional removable partial prosthodontics, 34-36 diagnosis, 37-43 digital dentistry, 44-47

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Platelet‐Rich Fibrin in Regeneration of Intrabony Defects: A Randomized Controlled Trial

Abstract: The adjunctive use of PRF to conventional OFD may be potentially used in the treatment of intrabony defects.

Cited by 63 publications

References 26 publications

Clinical and radiographic evaluation and comparison of bioactive bone alloplast morsels when used alone and in combination with platelet‐rich fibrin in the treatment of periodontal intrabony defects—A randomized controlled trial

Clinical and radiographic evaluation and comparison of bioactive bone alloplast morsels when used alone and in combination with platelet‐rich fibrin in the treatment of periodontal intrabony defects—A randomized controlled trial

Giant Peripheral Ossifying Fibroma Treated With Piezosurgery and Platelet‐Rich Fibrin: A Rare Case Report

Annual review of selected scientific literature: A report of the Committee on Scientific Investigation of the American Academy of Restorative Dentistry

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