“…Also, the present Meta-Analysis found that CAF + PRF did not increase %RC when compared to CAF alone (p = 0.60). In regards to healing and pain assessment, all the three studies that included HI and pain in their outcomes consistently reported a significant reduction in pain for the first 5-7 days and faster healing in the PRF intervention when compared to the use of CTG or EMD, which was consistent with numerous studies describing faster healing potential of growth factors in regenerative procedures [32,38,39,[47][48][49][50][51][52]. This finding is explained by PRF characteristics, when compared to other forms of blood derived growth factors like PRP, in the slow release of growth factors over a period of 10 days which is the time needed for revascularization and CT formation in a soft tissue regeneration procedure, while PRP was known for an earlier release of growth factors in the healing cascade [53][54][55].…”