Platelet-rich fibrin (PRF) in implants dentistry in combination with new bone regenerative flapless technique: evolution of the technique and final results

Cortese, Antonio; Pantaleo, Giuseppe; Amato, Massimo; Howard, Candace M.; Pedicini, Lorenzo; Claudio, Pier Paolo

doi:10.1515/med-2017-0005

Cited by 15 publications

(14 citation statements)

References 34 publications

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“…Some studies have demonstrated that L‐PRF compressed clot alone produced favorable clinical outcomes in the treatment of infrabony periodontal defects (Chang et al, ; Zhao et al, ; Sharma and Pradeep, ; Ajwani et al, ; Chandradas et al, ), protected open wounds in the oral cavity (Asaka et al, ), sped up the healing of hard and soft tissues (Marenzi et al, ; Simon et al, ; Boora et al, ; Tunali et al, ; Eren et al, ; Kotsakis et al, ), reduced the rates of alveolitis after tooth extractions (Eshghpour et al, ; Kumar et al, ), and improved BV in preprosthetic surgeries and the osseointegration of dental implants (Oncu and Erbeyoglu, ; Castro et al, ; Cortese et al, ; Kanayama et al, ; Aoki et al, ; Oncu and Alaaddinoglu, ; Oncu et al, ; Boora et al, ; Simon et al, ).…”

Section: Introductionmentioning

confidence: 99%

Effects of leukocyte‐ and platelet‐rich fibrin associated or not with bovine bone graft on the healing of bone defects in rats with osteoporosis induced by ovariectomy

Engler-Pinto

Siéssere

Calefi

et al. 2019

Clinical Oral Implants Res

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Objective To evaluate the healing of critical size defects (CSDs) in calvaria of rats with osteoporosis induced by ovariectomy and treated with leukocyte‐ and platelet‐rich fibrin (L‐PRF) associated or not with bovine bone graft (XENO). Material and Methods A total of 32 rats underwent a bilateral ovariectomy procedure. After 3 months, one 5 mm in diameter CSD was created in the middle of the calvaria of each animal. In group C, defect was filled with blood clot only. In PRF, XENO, and PRF‐XENO groups, defects were filled with 0.1 ml of L‐PRF, 0.1 ml of XENO, and a mixture of 0.1 ml of L‐PRF plus 0.1 ml of XENO, respectively. L‐PRF compressed clots were used to cover the defects in PRF and PRF‐XENO groups. Animals were submitted to euthanasia at 30 postoperative days. Histomorphometric, microtomographic, and immunohistochemical analyses were performed. Results PRF‐XENO group presented greater amount of neoformed bone (NB) when compared with XENO group, as well as higher expression of vascular endothelial growth factor (VEGF), osteocalcin (OCN), and bone morphogenetic protein (BMP‐2/4) (p < .05). PRF group presented increased amount of NB and higher expression of VEGF, OCN, BMP‐2/4, and Runt‐related transcription factor 2 (RUNX‐2) when compared with group C (p < .05). Conclusions (a) The isolated use of L‐PRF clot can improve bone neoformation in CSDs in rats with osteoporosis induced by ovariectomy, but seems to lead to decreased amount of bone neoformation when compared to the isolated use of XENO; (b) L‐PRF potentiates the healing of XENO in rats with osteoporosis induced by ovariectomy.

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Section: Introductionmentioning

confidence: 99%

Effects of leukocyte‐ and platelet‐rich fibrin associated or not with bovine bone graft on the healing of bone defects in rats with osteoporosis induced by ovariectomy

Engler-Pinto

Siéssere

Calefi

et al. 2019

Clinical Oral Implants Res

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“…The increasing interest in understanding the effects of platelet concentrate application on bone tissue is reflected in the number of recent studies that have examined this topic (Al‐Hamed et al, ; Canellas et al, ; Cortese et al, ; Isobe et al, ; Panda et al, ). Although there have been studies that have used models of bone lesions in animals to clarify the effects of these platelet concentrates at different levels (Acar et al, ; Bölükbaşı, Yeniyolm, Tekkesinm, & Altunatmaz, ; Du et al, ; Ocak et al, ), there are also clinical studies that focus on radiological (Cortese et al, ; Park et al, ) and tomographic analyses (Lim et al, ; Montanari, Callea, Yavuz, & Maglione, ; Öncü & Kaymaz, ) and its use in clinical settings (Barone et al, ; Panda et al, ; Sezgin, Uraz, Taner, & Çulhaoğlu, ), all of which seek to evaluate the effects of this therapy. Our clinical case study differs from these investigations as it evaluates the ultrastructure of neoformed bone tissue and the quantity of inorganic elements of HA present.…”

Section: Discussionmentioning

confidence: 99%

“…This biomaterial acts as a biodegradable scaffold and favors the development of microvascularization. It may also guide epithelial cell migration to the surface (Cortese et al, ).…”

Section: Introductionmentioning

confidence: 99%

“…PRF is a curative biomaterial that has been applied as a barrier membrane and/or as a carrier of growth factors, which has shown a great potential for bone and soft tissue regeneration and is free from inflammatory reactions. It may be used alone or in combination with bone grafts, thus promoting hemostasis, bone growth, and maturation (Cortese et al, ; Isobe et al, ).…”

Section: Introductionmentioning

confidence: 99%

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Platelet‐rich fibrin and collagen membrane in the preservation of the alveolar bone: Feasibility of the elemental inorganic composition and scanning electron microscopy analysis

Días

Arias

Borie

et al. 2019

Microscopy Res & Technique

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The success of dental implants is related to the amount, quality, and composition of the alveolar bone. The placement of platelet-rich fibrin (PRF) clot associated with a resorbable collagen membrane (RCM) in a postextraction alveolus is a technique used for ridge preservation. This case report study analyzed the ultrastructural characteristics of cross-sectioned alveolar bone that received PRF and RCM using scanning electron microscopy and the inorganic composition using "energy dispersive X-ray spectrometry," in order to explore the feasibility of this method to clinical studies.Three alveolar bone samples from two male patients (37 and 58 years old), obtained in the procedure of placing the dental implant, were analyzed. Two bone samples previously received PRF and RCM (M37 and M58), the third sample represented a physiological bone formation without treatment (M37-control). The bone sample M37 showed irregularly shaped islets of calcified material intermingled with connective tissue. The other samples, from the 58-year-old patient with PRF and RCM (M58); and the other untreated bone sample from the same 37-year-old patient (M37-control) showed similar ultrastructural morphology with trabecular conformation without islets agglomerations. The inorganic composition analysis showed higher concentrations of calcium and phosphorus in both samples treated with PRF and RCM in comparison to the untreated bone sample. The Ca/P ratio was higher in the M37 sample compared to the others samples. The results showed morphology and inorganic composition differences among the treatments used, suggesting that this method is feasible to analyze parameters of the alveolar bone tissue.

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“…The bone walls of the buccal section are generally broken or detached with the tooth. 3 Bone deficits in vertical and/or horizontal dimensions will prevent from an ideal implant placement. Therefore it is necessary to perform graft-supported bone augmentation.…”

Section: Introductionmentioning

confidence: 99%

Use of bones taken from the operated areas of impacted third molars as autografts for implant placement: cases report

Putra

Ramadhonie

Rahajoe

2018

J Dentomaxillofac Sci

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Objective: This report aims to explain how the bones taken from the operated areas of impacted third molars are used as autografts for implant placement. Methods: Two patients with missing maxillary incisor, lack of alveolar bone support and impacted third molar underwent an implant placement procedure with bone grafting and third molar removal, subsequently. In both cases, the implant was placed and resulted in a dehiscence-typed defect. The defect was filled with an autograft harvested from the operated area of impacted third molar, and then covered with PRF membrane and titanium mesh. The wound was sutured accordingly and evaluation was taken 3 months following the procedure. Results: Under direct observation, in both cases, new bone formation appeared in the buccal region of the implant to the margin of the implant crestal. The implant was stable and no complications occurred. Conclusion: On the basis of this finding, it can be concluded that operated area of impacted third molar can be considered as an ideal alternative for donor sites for patients who needed bone grafts and third molar extraction simultaneously.

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Platelet-rich fibrin (PRF) in implants dentistry in combination with new bone regenerative flapless technique: evolution of the technique and final results

Cited by 15 publications

References 34 publications

Effects of leukocyte‐ and platelet‐rich fibrin associated or not with bovine bone graft on the healing of bone defects in rats with osteoporosis induced by ovariectomy

Effects of leukocyte‐ and platelet‐rich fibrin associated or not with bovine bone graft on the healing of bone defects in rats with osteoporosis induced by ovariectomy

Platelet‐rich fibrin and collagen membrane in the preservation of the alveolar bone: Feasibility of the elemental inorganic composition and scanning electron microscopy analysis

Use of bones taken from the operated areas of impacted third molars as autografts for implant placement: cases report

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