Platelet-Rich Fibrin Sealant as a Treatment for Complex Perianal Fistulas: A Multicentre Study

Lara, Francisco Javier Pérez; Serrano, Almudena Moreno; Moreno, Johana; Carmona, J. Hernández; Márquez, Manuel; Perez, Leanne; Moreno, Arturo del Rey; Muñoz, H. Oliva

doi:10.1007/s11605-014-2698-7

Cited by 34 publications

(26 citation statements)

References 35 publications

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“…18,19 5 Lara ve ark. 23 yaptığı 2015 yılında yayınlanan prospektif çok merkezli çalışmada 60 hasta üstünde yapılan uygulamada ortalama takip süresi 24 ay olup 40 hastada (%66) fistülün kapandığını ve hiçbir hastada anal inkontinans gelişmediğini rapor etmişler. Bu çalışmada intersfinkterik fistüllerde %87,5 (n=8), alçak transsfinkterik fistüllerde %61,54 (n=13), orta transsfinkterik fistüllerde %64,52 (n=31), yüksek transsfinkterik fistüllerde %57,14 (n=7), suprasfinkterik fistüllerde %100 (n=1) başarı sağlanmış.…”

Section: Discussionunclassified

“…Bu çalışmada intersfinkterik fistüllerde %87,5 (n=8), alçak transsfinkterik fistüllerde %61,54 (n=13), orta transsfinkterik fistüllerde %64,52 (n=31), yüksek transsfinkterik fistüllerde %57,14 (n=7), suprasfinkterik fistüllerde %100 (n=1) başarı sağlanmış. 23 Bu çalışmanın negatif özelliği suprasfinkterik fistül sayısının çok az olması ve at nalı fistüllerde uygulanmamış olmasıdır. Kompleks anal fistülün tedavisinde nüksü ve anal inkontinansı azaltmak için başka birçok yöntem denenmiştir.…”

Section: Discussionunclassified

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Closure of Fistula Tract With Filac™ Laser As a Sphincter Preserving Method in Anal Fistula Treatment

Dönmez¹,

Hatipoğlu²

2018

TJCD

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Section: Discussionunclassified

Closure of Fistula Tract With Filac™ Laser As a Sphincter Preserving Method in Anal Fistula Treatment

Dönmez¹,

Hatipoğlu²

2018

TJCD

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“…In the management of fistulas, to date only one multicenter study has been reported (15), which includes the experience of some hospitals in this setting. The remaining studies (16,17) are to demonstrate the closure of upper perianal fistulas with a technique combining advancement flaps and platelet-rich plasma.…”

Section: Discussionmentioning

confidence: 99%

Using autologous platelet-rich plasma for the treatment of complex fistulas

Moreno-Serrano¹,

García-Díaz²,

Ferrer-Márquez³

et al. 2016

Rev Esp Enferm Dig

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Objective:This study aims to demonstrate the effectiveness and safety of autologous fibrin gel rich in platelet growth factors for the treatment of complex perianal fistulas.Material and methods: Prospective epidemiological study. Patients with complex perianal fistula or perianal fistula mere alteration of continence are included. identification of both holes and the journey, curettage of it and instillation of Vivostat PRF ® in the way it is done to observe excess material by OFE. The variables analyzed were: age, sex, use of prior Seton clinic prevalent type of fistula, postoperative complications, fistula closure and impaired quality of life using the SF-36 test (v2).Results: From January 2011 to May 2013 have involved 23 patients, 12 men and 11 women, with an average age of 49 years and a minimum follow-up of 12 months. Two dropped out. 17 patients had low transsphincteric fistulas, 2 and 2 high transsphincteric intersphincteric with impaired continence. The most common symptom is the discharge. Twelve patients had a loose seton (62%), of which nine cured. Of all the patients we have operated the success rate is 62%. No patient developed incontinence after treatment. Only two reported a worse quality of life after surgery.Conclusion: This study demonstrates that there is a clear benefit to the use of Vivostat PRF ® as a treatment for complex perianal fistulas. It is a highly reproducible technique with acceptable results and does not produce impairment of continence.

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“…In view of these applications, we began to treat complex perianal fistulas by sealing them with PRF. Our multi-center study reported a success rate of 66% with this approach (24).…”

Section: Discussionmentioning

confidence: 69%

Method for Management of Perianal Fistula with New Device: Progressive Curettage of the Tract and Sealing with Platelet-Rich Fibrin

Lara¹,

Berges²,

González³

et al. 2016

Ann Colorectal Res

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Surgical treatment of high perianal fistulas, which affect a significant proportion of the sphincter apparatus, is difficult and associated with considerable risk of impaired anal continence. The diversity of approaches proposed for the treatment of complex perianal fistulas reflects the fact that no method has yet been shown to be fully satisfactory. We believe the successful treatment of this condition is directly proportional to the amount of fibrous tissue that can be removed. We used a kit of small curettes, of different thicknesses and sizes, incorporating spicules that enable the physician to remove fibrous tissue from the fistula tract. The small size and varying thicknesses of the curettes enable them to mold to the curves of the fistula tract and to remove tissue by de-roofing from the shallowest to the deepest layers, thus excising the entire fibrous tract. The tract is then sealed using autologous fibrin, applied through a catheter, with the help of a monitor indicating the amount of product remaining at all times. Finally, the internal orifice is closed by simple suturing.

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Platelet-Rich Fibrin Sealant as a Treatment for Complex Perianal Fistulas: A Multicentre Study

Abstract: In our opinion, this procedure is safe and its results are promising in terms of clinical outcome and medium- to long-term quality of life.

Cited by 34 publications

References 35 publications

Closure of Fistula Tract With Filac™ Laser As a Sphincter Preserving Method in Anal Fistula Treatment

Closure of Fistula Tract With Filac™ Laser As a Sphincter Preserving Method in Anal Fistula Treatment

Using autologous platelet-rich plasma for the treatment of complex fistulas

Method for Management of Perianal Fistula with New Device: Progressive Curettage of the Tract and Sealing with Platelet-Rich Fibrin

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