Platelet‐Rich FibrinNatural and Biologic Blood Concentrate

Choukroun, Joseph; Aalam, Alexandre‐Amir

doi:10.1002/9781119019916.ch33

Cited by 1 publication

(1 citation statement)

References 13 publications

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“…As reported before, these biochemical modifications could alter the fibrin structure [36,37]. Our L-PRF-obtaining protocol does not include the use of biochemical modifiers of the coagulation cascade, and clotting occurs physiologically [38,39]. The use of anticoagulated plasma and other experimental design conditions could explain the differences in SEM observations between this study and previous reports on the clot structure of smokers.…”

Section: Discussionmentioning

confidence: 71%

Leukocyte- and Platelet-Rich Fibrin (L-PRF) Obtained from Smokers and Nonsmokers Shows a Similar Uniaxial Tensile Response In Vitro

Lara,

Bezmalinovic,

García-Herrera

et al. 2023

Biomedicines

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We evaluated and compared the biomechanical properties of Leukocyte-and Platelet Rich Fibrin L-PRF clots and membranes derived from smoker and nonsmoker donors. Twenty venous-blood donors (aged 18 to 50 years) were included after signing informed consent forms. L-PRF clots were analyzed and then compressed to obtain L-PRF membranes. L-PRF clot and membrane samples were tested in quasi-static uniaxial tension and the stress–stretch response was registered and characterized. Furthermore, scanning electron microscope representative images were taken to see the fibrin structure from both groups. The analysis of stress–stretch curves allowed us to evaluate the statistical significance in differences between smoker and nonsmoker groups. L-PRF membranes showed a stiffer response and higher tensile strength when compared to L-PRF clots. However, no statistically significant differences were found between samples from smokers and nonsmokers. With the limitations of our in vitro study, we can suggest that the tensile properties of L-PRF clots and membranes from the blood of smokers and nonsmokers are similar. More studies are necessary to fully characterize the effect of smoking on the biomechanical behavior of this platelet concentrate, to further encourage its use as an alternative to promote wound healing in smokers.

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