Platelet-rich growth factor in oral and maxillofacial surgery

Pal, Uma Shanker; Mohammad, Shadab; Singh, Rakesh Kumar; Das, Sankha Subhra; Singh, Nidhi; Singh, Mayank

doi:10.4103/0975-5950.111340

Cited by 20 publications

(13 citation statements)

References 52 publications

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“…Platelets contained granules and growth factors, such as TGF-β, PDGF, IGF, VEGF, EGF and FGF-2 (Christgau et al, 2006), which stimulate the inflammatory cascade and healing process. PDGF plays an important role in cell proliferation, angiogenesis tissue and mucous regeneration (Kim and Yun, 2007;Alio et al, 2012;Pal et al, 2012;Sclafani and McCormick, 2012). Angiogenesis can be effective in the production of natural vaginal discharge and lubrication during intercourse.…”

Section: Discussionmentioning

confidence: 99%

Autologous Platelet-Released Growth Factor and Sexual Dysfunction Amendment: A Pilot Clinical Trial of Successful Improvement Sexual Dysfunction after Pelvic Irradiation

Nouroozi

Alyasin

Mohammadi

et al. 2019

Asian Pac J Cancer Prev

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Sexual dysfunction (SDF) is a common sequel to cancer treatment which affects the quality of life in women treated with pelvic radiotherapy. The aim of this study was to evaluate the safety, symptom resolution and objective improvement the injection of autologous platelet released growth factor (APRGF) for treatment of SDF in cited patients. This prospective pilot study enrolled 10 cancer-free patients with SDF who underwent pelvic radiotherapy at least 5 years ago, randomly. Each patient was received 1-2 cc APRGF within four weeks and all patients were re-evaluated at eight weeks and six months. CD34 immuno histochemistry and Masson’s trichrome staining were performed on vaginal biopsy section for angiogenesis and fibrosis assay respectively. Sexual satisfaction after the injection of APRFG was clinically difference and the entire patient had sexual satisfaction. In the patient’s follow-up, none of them needs to repeat the treatment. Our results declared that APRGF injection was effective and symptoms were disappeared in the entire patients. Significant objective improvements in vaginal diameter (mean before injection, 6.5 cm vs 7.1 cm after injection) (p-value = 0.001) and vaginal flexibility (mean before treatment, 0.72 cm vs 1.85 cm after injection) (P-value = 0.026) were observed. Characteristics of discharge before the injection in 60% of patients were included dry vagina and 40% had mild discharge but after injection 40% of patients had moderate and also 60% had mild and sufficient discharge (P-value= 0.190). Overally, our patients reported better sexual function and showed better vaginal function indexes, after APRFG injection.

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Section: Discussionmentioning

confidence: 99%

Autologous Platelet-Released Growth Factor and Sexual Dysfunction Amendment: A Pilot Clinical Trial of Successful Improvement Sexual Dysfunction after Pelvic Irradiation

Nouroozi

Alyasin

Mohammadi

et al. 2019

Asian Pac J Cancer Prev

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“…The use of PRP in maxillofacial and orthopedic surgery has demonstrated its effectiveness because the presence of the previously mentioned growth factors included in the PRP promotes a shorter wound healing period. 32,33 It is therefore evident that in a pocket of soft tissues, vascular healing and final tissue remodeling will be of greater quality. [34][35][36]…”

Section: Discussionmentioning

confidence: 99%

Diced and Crushed Cartilage Plus Autologous Fibrin Matrix Obtained by a Simple Process for Dorsal Augmentation of the Mestizo Nose

et al. 2015

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Several alternatives can be used for nasal dorsum augmentation. We report the use of crushed diced cartilage embedded in an autologous fibrin matrix. This construct is placed on the nasal dorsum and is gently molded according to the characteristics of each patient. Rhinoplasty and nasal dorsum augmentation were performed in 45 patients with Mestizo characteristics after a complete medical history and development of a surgical plan. A crushed diced cartilage autologous graft and an autologous fibrin matrix from peripheral blood processed using the Choukroun method was used. Pre- and postoperative photographs were taken at short- and long-term follow-up. Two separate variables were evaluated: reabsorption and irregularities. Three plastic surgeons evaluated the results, using a Likert scale: the first variable was considered very excellent in 88.9%, very good in 6.7%, good in 4.4% with no poor or very poor results. In the second variable, results were excellent in 88.9%, very good in 4.4%, good in 3.4%, and poor in 3.3% with no very poor results. Our patients carry a volume with an aesthetically pleasing contour and form with no changes over a mean follow-up period of 4 years. Long-term effectiveness continues to be the main topic of discussion; however, this method can be considered an alternative not only to augment but also to smoothen irregularities of the nasal dorsum. We used a simple method with good and stable long-term clinical results.

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“…The protocol is unique because it does not include leucocytes in its composition; moreover, PRGF can be used in different clinical forms 4,5 . It is known that the proteins derived from platelets such as platelet‐derived growth factor (PDGF), transforming growth factor (TGF‐β), vascular endothelial growth factor (VEGF) and epidermal growth factor (EGF), also plasma containing certain natural growth factors in the name of insulin‐like growth factor (IGF), fibroblast growth factor (b‐FGF) and nerve growth factor (NGF) are able to promote angiogenesis and enhance muscle regeneration 6‐8 . Moreover, it has also been proven that platelet‐rich plasma can reduce chronic pain 9 .…”

Section: Introductionmentioning

confidence: 99%

Plasma rich in growth factors injection effectiveness for myofascial pain treatment in masticatory muscles. Randomised controlled trial

Šakalys

Rokicki

Janužis

et al. 2020

J of Oral Rehabilitation

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Background Myofascial pain in masticatory muscles is one of the most common temporomandibular disorder. Nowadays, the most usable treatment methods are based on the muscle taut band cell membrane disruption, which releases the taut band. Platelet‐rich plasma, made with PRGF Endoret® method, gives an opportunity to use platelet‐derived growth factors in treatment processes. It has been proven that platelet‐derived growth factors can relief pain and activate muscle regeneration. Objective To test a hypothesis that PRGF injections can be effective for treating myofascial pain in masticatory muscles. Methods Fifty adult patients participated in the study. Participants were randomly divided into two groups. The first group received 1‐mL lidocaine injections to trigger point in their masseter muscle. The second group of patients received 1‐mL PRGF injections. The patients' pain was measured by using visual analogue scale (VAS). Result Statistically significant difference in pain levels before the procedure and 4 weeks after it was found in both groups. There was no statistically significant difference between groups in pain levels before the procedure (P = .063) and 2 weeks after it (P = .123); however, statistically significant difference was noticed 4 weeks after the procedure (P < .001). Four weeks after the procedure, patients' average pain in lidocaine group was 3.4 on VAS, and it was 0.9 in PRGF group. Conclusions PRGF injections in masseter muscle affected by myofascial pain syndrome are an effective treatment method. PRGF injections more effectively relief myofascial pain in masseter muscle than lidocaine injections.

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Platelet-rich growth factor in oral and maxillofacial surgery

Cited by 20 publications

References 52 publications

Autologous Platelet-Released Growth Factor and Sexual Dysfunction Amendment: A Pilot Clinical Trial of Successful Improvement Sexual Dysfunction after Pelvic Irradiation

Autologous Platelet-Released Growth Factor and Sexual Dysfunction Amendment: A Pilot Clinical Trial of Successful Improvement Sexual Dysfunction after Pelvic Irradiation

Diced and Crushed Cartilage Plus Autologous Fibrin Matrix Obtained by a Simple Process for Dorsal Augmentation of the Mestizo Nose

Plasma rich in growth factors injection effectiveness for myofascial pain treatment in masticatory muscles. Randomised controlled trial

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