Platelet-Rich Plasma

Le, Angela; Enweze, Lawrence; DeBaun, Malcolm R.; Dragoo, Jason L.

doi:10.1016/j.csm.2018.08.001

Cited by 107 publications

(91 citation statements)

References 140 publications

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“…Citrate binds calcium ions (Ca 2+ ) to avoid plasma coagulation and allows platelet activation and aggregation [170]. Platelet-rich plasma (PRP) used in paper III was obtained as previously described [138,171], although there are several methods to obtain PRP [172]. The methods may differ in the isolation procedure (1-step or 2-step centrifugation), the speed of centrifugation, and the type of collection tube system and operation.…”

Section: Isolation Of Platelet-rich Plasma and Plateletsmentioning

confidence: 99%

Glycosylation is important for legumain localization and processing to active forms but not for cystatin E/M inhibitory functions

et al. 2017

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Section: Isolation Of Platelet-rich Plasma and Plateletsmentioning

confidence: 99%

Glycosylation is important for legumain localization and processing to active forms but not for cystatin E/M inhibitory functions

et al. 2017

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“…Therefore, noninvasive therapies are noteworthy. In this case, PRP, which is safe because it is produced from the patient’s own blood 30,31 and may be an alternative to surgery and other medications with many side effects, as a minimally invasive agent in the treatment of endometriosis.…”

Section: Discussionmentioning

confidence: 99%

The Effects of Leukocyte- and Platelet-Rich Plasma (L-Prp) and Pure Platelet-Rich Plasma (P-Prp) an a Rat Endometriosis Model

Anğın

Gün

Sakin

et al. 2019

Preprint

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29Our aim was to investigate the effect of platelet-rich plasma (PRP) derivatives, which 30 can be produced from the patient's own blood and have minimal side effects, on 31 endometriosis. To the best of our knowledge, this is the first study in the literature that studies 32 the relationship between PRP and endometriosis. Endometriosis foci were created in the first 33 operation. In the second operation (30 th day) groups were formed. Group 1 (n= 8) was 34 administered saline, group 2 (n= 7) leukocyte-and platelet-rich plasma (L-PRP), and group 3 35 (n= 8) pure platelet-rich plasma (P-PRP). Group 4 (n= 10) was used to obtain PRP. In the last 36 operation (60 th day), the endometriotic foci were measured, and then excised. There was no 37 statistically significant difference between the pre and post volumes of the endometriotic foci, 38 between their volume differences and volume difference rates (p > .05). However, it was 39 observed that existing implant volumes in all groups decreased statistically significantly 40 within their own groups by the end of the experiment compared to the previous volumes (p < 41 .05). When the implants were assessed through histopathological scoring in terms of edema, 42 vascular congestion, inflammatory cell infiltration, hemorrhage, epithelial line, and 43 hemosiderin accumulation and immunohistochemical staining in terms of VEGF, there was 44 no significant difference in the comparison between the groups. Although L-PRP and P-PRP 45 generated more reduction in the endometriosis foci, they did not create any statistical 46 differences. 48Endometriosis, which is described as the presence of endometrial gland and stroma 49 outside the uterine cavity, is an important women's health problem seen in 6-10% of women 50 that causes degradation in the quality of life with clinical effects, such as infertility, 3 51 dysmenorrhea, dyspareunia and chronic pelvic pain 1-4 . Its pathophysiology has not yet been 52 fully resolved, and an effective treatment for it has not yet been found 5,6 . 53

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“…However, PRP is not registered as a treatment method to any disease (FDA has not approved it) whereas this procedure is very often used in other indications. In literature we can find reports connected with PRP usefulness in different disorders such as tissue regeneration, wound healing, scar revision, musculoskeletal maladies, skin rejuvenating effects, and some types of alopecia (Alves & Grimalt, 2018;Lee, Enweze, DeBaun, & Dragoo, 2019;Smith, Jell, & Mosahebi, 2018).…”

Section: Introductionmentioning

confidence: 99%

Serum sickness disease in a patient with alopecia areata and Meniere’ disease after PRP procedure

Owczarczyk‐Saczonek

Wygonowska

Budkiewicz³

et al. 2019

Dermatologic Therapy

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Background: Platelet rich plasma procedure (PRP) is considered to be one of the safest aesthetic procedures. Adverse reactions after PRP administration are extreme rare. Purpose: We present the patient with serum sickness disease (SSD) after PRP procedure. Objective and methods: 41 years old female suffers from alopecia areata for 5 years with frequent relapses and she has been suffering from Menier's disease recurrent symptoms for 6 years. The patient developed SSD after third PRP rejuvenating procedure and she has also noticed new alopecia areata lesions, but without Menier's disease symptoms. After SSD, 4 months later, she developed severe symptoms of Menier's disease with an episode of sudden sensorineural hearing loss. It alleviated only after intravenous administration of methylprednisolone. In our opinion, significant contraindication of PRP procedure is an autoimmune disease in the active phase.

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Platelet-Rich Plasma

Cited by 107 publications

References 140 publications

Glycosylation is important for legumain localization and processing to active forms but not for cystatin E/M inhibitory functions

Glycosylation is important for legumain localization and processing to active forms but not for cystatin E/M inhibitory functions

The Effects of Leukocyte- and Platelet-Rich Plasma (L-Prp) and Pure Platelet-Rich Plasma (P-Prp) an a Rat Endometriosis Model

Serum sickness disease in a patient with alopecia areata and Meniere’ disease after PRP procedure

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